Comparison of intensity modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) and a 3-dimensional conformal parotid gland-sparing radiotherapy (ConPas 3D-CRT) in treatment of nasopharyngeal carcinoma: a mono-institutional experience

Bišof, Vesna; Rakušić, Zoran; Bibić, Juraj; Grego, Timor; Soče, Majana

doi:10.1007/s11547-017-0824-9

Cited by 10 publications

(5 citation statements)

References 34 publications

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“…However, 5-year disease-specific survival rates were 81% in the CRT group and 85% in the IMRT group, while the corresponding neurological toxicity rates were 3.5% and 1.8%. However, Bisof et al [11] conducted a retrospective study to compare IMRT and CRT in the treatment of NPC with regard to outcomes and dose distribution to the planning target volumes and to the organs at risk. Results showed that the mean dose and dose to 50% parotid glands volume as well as the maximal dose to the spinal cord were significantly lower in the IMRT group than in the CRT group.…”

Section: Discussionmentioning

confidence: 99%

Oncologic outcomes of IMRT versus CRT for nasopharyngeal carcinoma

2019

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Background: Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in Asia particularly southern China. Comparisons of outcomes of conformal radiotherapy (CRT) and intensity-modulated radiotherapy (IMRT) have been still debated. This meta-analysis was carried out to compare oncologic outcomes of CRT and IMRT in the treatment of NPC. Methods: A literature search was performed through PubMed, Embase, and the Cochrane library databases from their inceptions to November 10, 2018. Two authors assessed the included studies and extracted data independently. Relative studies that compared oncologic outcomes between CRT and IMRT for NPC were included. Results: A total of 13 eligible studies were included, which contained 1 RCT, 1 prospective study, and 11 retrospective studies. Our meta-analysis showed that IMRT has increased overall survival (OR = 0.51, 95% CI = 0.41–0.65, P < .00001), locoregional control rate (OR = 0.59, 95% CI = 0.52–0.67, P < .00001), disease-free survival (OR = 0.77, 95% CI = 0.65–0.91, P = .002), and metastasis-free survival (OR = 0.71, 95% CI = 0.54–0.94, P = .01) in comparison with CRT. Conclusion: The results of this meta-analysis indicate IMRT should be a better option for the treatment of NPC because patients who underwent IMRT may benefit from increased overall survival, locoregional control rate, disease-free survival, and metastasis-free survival compared with CRT.

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Section: Discussionmentioning

confidence: 99%

Oncologic outcomes of IMRT versus CRT for nasopharyngeal carcinoma

2019

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“…Randomized studies in adults have reported a clear clinical benefit (in terms of survival and quality of life) for image‐guided radiotherapy (IGRT) and IMRT/volumetric modulated arc therapy (VMAT) compared to 2D‐ or even 3D‐conformal radiation therapy 92–95 . Several reports in childhood are also in favor of IGRT and IMRT/VMAT use for NPC treatment, with decreased rates of acute and late toxicities and a better survival 2,96,97 .…”

Section: Radiotherapy Techniquesmentioning

confidence: 99%

“…Randomized studies in adults have reported a clear clinical benefit (in terms of survival and quality of life) for image-guided radiotherapy (IGRT) and IMRT/volumetric modulated arc therapy (VMAT) compared to 2D-or even 3D-conformal radiation therapy. [92][93][94][95] Several reports in childhood are also in favor of IGRT and IMRT/VMAT use for NPC treatment, with decreased rates of acute and late toxicities and a better survival. 6,15,92,97,102 We recommend patients undergo audiometry studies and hearing evaluation, dental examination and endocrinology evaluation every 6 months for 36 months following treatment, and yearly thereafter (Level IV; Grade B).…”

Section: Radiotherapy Techniquesmentioning

confidence: 99%

Nasopharyngeal carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations

Ben-Ami

Kontny

Surun

et al. 2021

Pediatric Blood & Cancer

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Nasopharyngeal carcinoma (NPC) is a rare pediatric tumor. Collaborative studies performed over the last decades showed improved results compared to historical data, but standardized guidelines for diagnosis and management of pediatric NPC are still unavailable. This study presents a European consensus guideline for the diagnosis and treatment of pediatric NPC developed by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT). Main recommendations include induction chemotherapy with cisplatin and 5‐flurouracil, concomitant chemoradiotherapy in advanced disease, and to consider maintenance treatment with interferon beta (IFN‐β) for selected high‐risk patients. Dose adjustments of radiotherapy based on response to induction chemotherapy may decrease the rates of long‐term treatment‐related complications that affect most of the survivors.

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“…Intensity-modulated radiotherapy (IMRT) has been associated with a reduced toxicity profile in several head and neck tumors both in the curative and postoperative settings. However, its impact in SG cancer is currently supported by limited data [ 13 , 14 , 15 , 16 ]. The introduction of IMRT, as well as the addition of concurrent chemotherapy, has been associated with improved oncological outcomes in Dutch patients treated with chemoradiation for SG tumors [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes

Alterio

Marani

Zurlo

et al. 2022

Cancers

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The aim of the present study was to investigate the role of intensity-modulated radiotherapy (IMRT) on the toxicity profile of patients treated with conservative surgery (CS) of the supraglottic (SG) region. Data on patients treated with CS and postoperative radiotherapy (PORT)-IMRT were prospectively collected. Results. In total, 20 patients were analyzed. Of these, six patients (35%) required the positioning of a temporary tracheostomy. The functional larynx preservation rate was 95%. Females had a higher risk of both endoscopic intervention and chondronecrosis, while the median age was significantly higher in patients requiring enteral nutrition. The incidence of long-term severe toxicities was lower in patients treated with IMRT than in the historical 3D-CRT cohort. Patients who had received PORT-IMRT achieved a lower rate of permanent laryngeal and swallowing dysfunctions. Overall, results from the comparison with the historical 3D-CRT cohort favor the IMRTs.

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Comparison of intensity modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) and a 3-dimensional conformal parotid gland-sparing radiotherapy (ConPas 3D-CRT) in treatment of nasopharyngeal carcinoma: a mono-institutional experience

Abstract: IMRT-SIB provided additional spearing to parotid glands and spinal cord in comparison to ConPas 3D-CRT technique but without improvement of OS and DFS.

Cited by 10 publications

References 34 publications

Oncologic outcomes of IMRT versus CRT for nasopharyngeal carcinoma

Oncologic outcomes of IMRT versus CRT for nasopharyngeal carcinoma

Nasopharyngeal carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations

Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes

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