Comparison of Interactions Between Control and Mutant Macrophages

Abstract

This paper presents a preliminary study on macrophages migration in Drosophila embryos, comparing two types of cells. The study is carried out by a framework called macrosight which analyses the movement and interaction of migrating macrophages. The framework incorporates a segmentation and tracking algorithm into analysing motion characteristics of cells after contact. In this particular study, the interactions between cells is characterised in the case of control embryos and Shot3 mutants, where the cells have been altered to suppress a specific protein, looking to understand what drives the movement. Statistical significance between control and mutant cells was found when comparing the direction of motion after contact in specific conditions. Such discoveries provide insights for future developments in combining biological experiments to computational analysis.

Comparative Study of Contact Repulsion in Control and Mutant Macrophages Using a Novel Interaction Detection

“…A preliminary version of this work was presented at the 23rd Medical Image Understanding and Analysis (MIUA) [ 34 ]. The algorithms have been extended, and several new experiments with new data are presented.…”