Comparison of interferon-γ-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infection

Cowan, Juthaporn; Pandey, Sunita; Filion, Lionel G.; Angel, Jonathan B.; Kumar, Ashok; Cameron, D. William

doi:10.1111/j.1365-2249.2011.04520.x

Cited by 69 publications

(67 citation statements)

References 67 publications

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“…These results correlate with those of van Hamburg et al [122], who investigated the effects of the Th17 response on IL-22 in rheumatoid arthritis. As with Cowan et al [85], the levels of IL-22 were negatively correlated with the progression of disease; an interaction primarily mediated by Th17. This suggests that the Th17 response is modulated over time, such that the initial reaction to infection is one of concentrated and coordinated antimicrobial activity.…”

Section: Modulation Of the Immune Responsesupporting

confidence: 52%

“…Qiu et al [121] showed a depletion of IL-22 secretion in CD4+ T cells associated with Mtb infection. Cowan et al [85] found that both the Th17 response and IL-22 were differentially induced and observed a correlation between down regulation of IL-22 and progression of infection. These results correlate with those of van Hamburg et al [122], who investigated the effects of the Th17 response on IL-22 in rheumatoid arthritis.…”

Section: Modulation Of the Immune Responsementioning

confidence: 99%

“…The cells in and around the granuloma modulate the immune response to ensure minimal tissue damage [83,84]. These cells also continue to provide cytokines and factors, such as IFN-γ and TNF-α, to maintain the appropriate Th1 response to fight the infection [78,79], as well as IL-17 and IL-22 for the proinflammatory and the inflammatory response [85].…”

Section: Granuloma Formation and Disease Progressionmentioning

confidence: 99%

“…IL-22 is produced by a number of different cell types including neutrophils [85], NK and NKT cells [131], lymphoid tissue inducer cells, and innate lymphoid cells [132] and T cells, including a subset called Th22 cells. These latter cells are described as CD4+ T cells that produce IL-22 with minimal to no expression of IL-17 in response to .…”

Section: Alternate Strategies In Vaccine Developmentmentioning

confidence: 99%

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Vaccines against Mycobacterium Tuberculosis: Exploring Alternate Strategies to Combat a Near-perfect Pathogen

Filion¹,

Al‐Ahdal²,

Tetro³

2013

Mycobact Dis

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Section: Modulation Of the Immune Responsesupporting

confidence: 52%

Section: Modulation Of the Immune Responsementioning

confidence: 99%

Section: Granuloma Formation and Disease Progressionmentioning

confidence: 99%

Section: Alternate Strategies In Vaccine Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Vaccines against Mycobacterium Tuberculosis: Exploring Alternate Strategies to Combat a Near-perfect Pathogen

Filion¹,

Al‐Ahdal²,

Tetro³

2013

Mycobact Dis

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“…IL-17 is an important cytokine in mycobacterial infection; it not only contributes to the formation of granulomas, but also controls bacterial growth (Khader et al, 2007;Cruz et al, 2010;Torrado and Cooper, 2010;Cowan et al, 2012). RORgt was significantly induced at day 20 post infection, but decreased thereafter.…”

Section: Discussionmentioning

confidence: 99%

Prominent contribution of Th1, Th17, and Tregs to the host response during M. neoaurum infection

et al. 2016

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ABSTRACT. Nontuberculous mycobacteria are ubiquitous in outside environment and animals. As for nontuberculous mycobacteria infection, there is only limited information in humans regarding infection and the subsequent immune response, especially for Mycobacterium neoaurum. Here, haematoxylin-eosin and Ziehl-Neelsen staining were used to observe pathological changes and detect acid-fast bacilli in organ samples in mouse model. tissues. Our results indicated that 72% of CD4+ T cells appeared in the early days of infection, which was followed by a decrease to 47% by day 32, and then a rise to 76% by day 56. Moreover, we found higher frequency of IFN-g-producing CD4+ T cells and elevated mRNA expression of the transcription factor T-bet in the lungs; however, we observed lower mRNA expression of the transcription factor RORgt and lower frequency of IL-17-producing CD4+ T cells. A transient relative decrease in the number of Treg cells was observed in the lungs; however, the number of Tregs did not change significantly between the first and last day following infection. Thus, M. neoaurum causes chronic infection in C57BL/6 mice, with Th1, Th17, and Tregs playing a prominent role in the host response. The present study may lay the basis for further studies on the mechanisms underlying infection with nontuberculous mycobacteria.

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Phosphorylated STAT3 and PD‐1 regulate IL‐17 production and IL‐23 receptor expression in Mycobacterium tuberculosis infection

et al. 2014

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SUMMARY We studied the factors that regulate IL-23 receptor expression and IL-17 production in human tuberculosis infection. Mycobacterium tuberculosis (M. tb)-stimulated CD4+ cells from tuberculosis patients secreted less IL-17 than did CD4+ cells from healthy tuberculin reactors (PPD+). M. tb cultured monocytes from tuberculosis patients and PPD+ donors expressed equal amounts of IL-23p19 mRNA and protein, suggesting that reduced IL-23 production is not responsible for decreased IL-17 production by tuberculosis patients. Freshly isolated and M. tb- stimulated CD4+ cells from tuberculosis patients had reduced IL-23 receptor and phosphorylated STAT3 (pSTAT3) expression, compared to PPD+ donors. STAT3 siRNA reduced IL-23 receptor expression, and IL-17 production by CD4+ cells from PPD+ donors. Tuberculosis patients had increased number of PD-1+ T cells compared to healthy PPD+ individuals. Anti-PD-1 antibody enhanced pSTAT3 and IL-23R expression and IL-17 production by M. tb cultured CD4+ cells of tuberculosis patients. Anti-tuberculosis therapy decreased PD-1 expression, increased IL-17 and IFN-γ production and pSTAT3, IL-23R expression. These findings demonstrate that increased PD-1 expression and decreased pSTAT3 expression reduces IL-23 receptor expression and IL-17 production by CD4+ cells of tuberculosis patients.

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Comparison of interferon-γ-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infection

Abstract: SummaryIn this study, we investigated the role and expression of T helper type 17 (Th17) cells and Th17 cytokines in human tuberculosis. We show that the basal proportion of interferon (

Cited by 69 publications

References 67 publications

Vaccines against Mycobacterium Tuberculosis: Exploring Alternate Strategies to Combat a Near-perfect Pathogen

Vaccines against Mycobacterium Tuberculosis: Exploring Alternate Strategies to Combat a Near-perfect Pathogen

Prominent contribution of Th1, Th17, and Tregs to the host response during M. neoaurum infection

Phosphorylated STAT3 and PD‐1 regulate IL‐17 production and IL‐23 receptor expression in Mycobacterium tuberculosis infection

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