Soil Organic Carbon (SOC) influences many soil properties including nutrient and water holding capacity, nutrient cycling and stability, improved water infiltration and aeration. It also is an essential parameter in the assessment of soil quality, especially for agricultural production. However, SOC mapping is a complicated process that is costly and time-consuming due to the physical challenges of the natural conditions that is being surveyed. The best model for SOC mapping is still in debate among many researchers. Recently, the development of machine learning and Geographical Information Systems (GIS) has provided the potential for more accurate spatial prediction of SOC content. This research was conducted in a relatively small-scale capacity in the Central Vietnam region. The aim of this study is to compare the accuracy of Inverse Distance Weighting (IDW), Ordinary Kriging (OK), and Random Forest (RF) methods for SOC interpolation, with a dataset of 47 soil samples for an area of 145 hectares. Three environmental variables including elevation, slope, and the Normalized Difference Vegetation Index (NDVI) were used for the RF model. In the RF model, the values of the number of variables randomly sampled as candidates at each split, (mtry), and the number of bootstrap replicates, (ntree), were determined in terms of 1 and 1,000 respectively The results at our research site showed that using IDW is the most accurate method for SOC mapping, followed by the methods of RF and OK respectively. Concerning SOC mapping based-on auxiliary variables, in areas where there is human activity, the selection of auxiliary variables should be carefully considered because the variation in the SOC may not only be due to environmental variables but also by farming technologies.