Comparison of interstitial brachytherapy and surgery as primary treatments for nasal vestibule carcinomas

Bussu, Francesco; Tagliaferri, Luca; Mattiucci, Gian Carlo; Parrilla, Claudio; Dinapoli, N.; Miccichè, Francesco; Artuso, A; Galli, Jacopo; Almadori, Giovanni; Valentini, Vincenzo; Paludetti, Gaetano

doi:10.1002/lary.25498

Cited by 62 publications

(66 citation statements)

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“…The definite inclusion of such recommendation in the guidelines will anyway require further prospective studies in larger series. Furthermore, we feel that many of the peculiarities of the vestibule malignancies, such as the easy exposure and catheter placement, the absence of vital structures in proximity, and the clear reconstructive issues after ablative surgery, are shared by the other above‐defined midface malignancies, for which primary/exclusive IRT treatment may offer specific advantages as well …”

Section: Discussionmentioning

confidence: 99%

“…The plastic tubes were always placed at the end of surgical resection and before flap insetting when reconstruction was performed (group III, 13 patients; Figure E,F). Exclusive interstitial IRT for a midface malignancy (primary, 23; recurrent, 6) for which surgical reconstruction was not expected to be fully satisfactory. For midface malignancy, we intend lesions arising at the junction between mucosal and skin surfaces, and typically at the level of the lips, cheek, and nose vestibule (group IV, 29 patients; Figure G,H).…”

Section: Methodsmentioning

confidence: 99%

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HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

et al. 2019

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Background Interventional radiotherapy (brachytherapy; IRT) reemerged in the last decades as a potentially useful tool in head and neck oncology after a set of clear technical improvements were developed. Methods Sixty‐one high dose ratio (HDR) IRT treatments were recommended and performed on 58 patients. We classified the cases into four relatively homogeneous groups based on the clinical needs that led to the recommended IRT. Also, we separately evaluated primary and recurrent cases. Results Disease‐specific survival was significantly different among the four treatment groups. The group with the best prognosis was the cohort treated locally by exclusive interstitial IRT for resectable midface malignancies (2‐year relapse‐free survival = 82%, disease‐specific survival = 89%). Conclusion HDR IRT is a valuable tool in well‐defined clinical situations and, in particular, in recurrences. In midface malignancies, it could become the preferred primary treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

et al. 2019

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“…Squamous cell carcinoma arising from the nasal vestibule is a rare condition accounting for about 1% of head and neck malignancies with several particularities concerning both staging and treatment [2]. It develops as a result of exposure to sunlight and ultraviolet radiation, toxic agents such as arsenic, scars caused by burns or injuries, chronic ulcer, extension of life expectancy, compromised immune status and genetic defects [3,4].…”

Section: Discussionmentioning

confidence: 99%

“…A combination of different treatment modalities (surgery, radiotherapy) should be considered in cases of locally advanced lesions and, most of all, clinical and/or pathological evidence of neck metastasis [2]. Chemotherapy has a limited place [16].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous squamous cell carcinoma of the columella with an unusual revelation: a rare case report and a literature review of its staging and management challenges

Chafiki¹,

Merzouqi²,

Aboulfadl³

et al. 2017

Gen Int Med Clin Innov

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“…Additionally, resection of skull base tumors is also often complicated by proximity or extension into critical structures resulting in suboptimal outcomes [13,14]. Cesium-131 (Cs-131) Brachytherapy (BRT) is an effective and highly conformal contemporary technique for administering further radiation in a previously irradiated field while limiting toxicity in the treatment of head and neck cancer [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Cesium-131 Brachytherapy Seeds for the Treatment of Sinonasal Carcinosarcoma: A Case Report and Literature Review

Kutler¹

2017

OHNS

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A 70-year old male with poor cognitive function presented to an outside hospital in November 2010 with recurrent left-sided epistaxis. This patient had a history significant for anaplastic oligoastrocytoma Patel KR, et al., J Otolaryng Head Neck Surg 2017, 3: Radiation-induced tumors of the skull base pose a significant treatment challenge. Temporary Brachytherapy (BRT) with Cesium-131(Cs-131) seeds is a novel therapeutic technique that holds significant potential for the achievement of local tumor control in patients with limited therapeutic options. MethodsWe report a 70 year-old patient with a history of anaplastic oligoastrocytoma who presented with recurrent left-sided epistaxis. Imaging and biopsy results revealed a high-grade carcinosarcoma of the paranasal sinuses and skull base. The Sinonasal Carcinosarcoma (SN-CS) was resected and the residual micro tumor was treated with Cs-131 BRT seeds attached to a vicryl mesh, which was removed 6 weeks later. ResultsFollow-up examination demonstrated no evidence of recurrence or metastasis for 9 months and the patient had an overall survival of 15 months after treatment with Cs-131 BRT. ConclusionTemporary BRT with Cs-131 seeds may play a pivotal role in achieving local tumor control and palliation in patients with aggressive skull base tumors who are precluded from receiving more extensive forms of radiotherapy.

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Comparison of interstitial brachytherapy and surgery as primary treatments for nasal vestibule carcinomas

Abstract: 4.

Cited by 62 publications

References 16 publications

HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

Cutaneous squamous cell carcinoma of the columella with an unusual revelation: a rare case report and a literature review of its staging and management challenges

Cesium-131 Brachytherapy Seeds for the Treatment of Sinonasal Carcinosarcoma: A Case Report and Literature Review

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