Comparison of Intima-Media Thickness of the Carotid Artery and Cardiovascular Disease Risk Factors in Adults With Versus Without the Down Syndrome

Draheim, Christopher C.; Geijer, Justin R.; Dengel, Donald R.

doi:10.1016/j.amjcard.2010.06.079

Cited by 62 publications

(65 citation statements)

References 16 publications

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“…LDLR-null mice have since been generated and is now a widely used atherosclerotic mouse model (Ishibashi et al 1993;Wouters et al 2005). Lastly, DS patients exhibit significantly elevated levels of plasma triglycerides, low levels of HDL, high levels of CRP, and high levels of total body fat (Corsi et al 2005;Draheim et al 2010;Nishida et al 1977). Taken together, these findings imply DS adults are surely at risk for cardiovascular events.…”

Section: Atherosclerosis In Down Syndromementioning

confidence: 62%

“…Additional population studies in DS patients have found consistent results (Draheim, Geijer & Dengel, 2010;Yla-Herttuala et al 1989), leading one to speculate that an unidentified factor(s) specific to DS patients explains the near absence of atherosclerotic plaque formation. Considering the vascular similarities between tumorigenesis and atherosclerosis, it is possible these events are driven by a shared molecular mechanism.…”

Section: Atherosclerosis In Ds Patientsmentioning

confidence: 92%

See 1 more Smart Citation

Down Syndrome and Vascular Disease: DSCR1 and NFAT Signaling

Lee¹,

Wamhoff²

2011

Genetics and Etiology of Down Syndrome

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Section: Atherosclerosis In Down Syndromementioning

confidence: 62%

Section: Atherosclerosis In Ds Patientsmentioning

confidence: 92%

Down Syndrome and Vascular Disease: DSCR1 and NFAT Signaling

Lee¹,

Wamhoff²

2011

Genetics and Etiology of Down Syndrome

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“…8,10 Among our patients, none presented hypertension; 11 cases (11.3%) were classified as presenting prehypertension, among which 9 presented obesity class II and III. These patients will be monitored through periodic measurements of their BP and referral for medical care.…”

Section: Discussionmentioning

confidence: 99%

“…Draheim et al 10 investigated 52 DS patients and reported that systolic and diastolic BP were significantly lower in adults with DS than in a matched control group; and that their body mass index (BMI) was 31.0 ± 6, which was significantly higher than that of the controls (28.0 ± 7). There are no studies on this topic conducted in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Blood pressure levels and body mass index in Brazilian adults with Down syndrome

et al. 2016

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CONTEXT AND OBJECTIVE: Increased life expectancy among people with Down syndrome (DS) has introduced new environmental factors that may affect blood pressure (BP) and/or lead to obesity in this population. The aim here was to investigate BP levels and body mass index (BMI) in adults with DS, correlating these data with the patients' sex and age. DESIGN AND SETTING: Analytical cross-sectional observational study conducted in special schools in Curitiba (PR), Brazil. METHODS: 97 adult patients were included. BP was measured in accordance with the established guidelines. BMI was calculated by dividing the weight by the height squared (kg/m 2 ). RESULTS: Sex had no influence on BMI; nor did systolic BP (SBP) or diastolic BP (DBP). The age range was from 18 to 56 years. No correlation was observed between increasing age and greater BMI or BP. Eighty-six individuals (88.7%) presented normal BP, eleven (11.3%) prehypertension and none hypertension. Twenty patients (20.4%) presented BP lower than 90 × 60 mmHg. BMI ranged from 18 to 48 kg/m 2 (mean of 28.8 ± 3.92 kg/m 2 ): 21.9% had normal weight; 40.7% were overweight; and 25.3% had obesity class I, 9.9% class II and 2.2% class III. Higher BMI was associated with significantly greater SBP and DBP (P = 0.0175 and P = 0.0015). CONCLUSION: Sex and age did not influence SBP, DBP or BMI in Brazilian adults with DS. Higher BMI was associated with greater BP (both systolic and diastolic). RESUMOCONTEXTO E OBJETIVO: O aumento da expectativa de vida das pessoas com síndrome de Down (SD) introduziu novos fatores ambientais que podem afetar a pressão sanguínea e/ou levar a obesidade nessa população. O objetivo foi investigar os níveis de pressão arterial (PA) e o índice de massa corporal (IMC) em adultos com SD, correlacionando estes dados com a idade e o gênero dos pacientes. DESENHO E LOCAL: Estudo observacional, transversal e analítico, realizado em escolas especiais em Curitiba (PR), Brasil. MÉTODOS: Foram incluídos 97 pacientes adultos. A aferição da PA foi feita de acordo com as diretrizes estabelecidas. O IMC foi calculado dividindo-se o peso pela altura ao quadrado (kg/m 2 ). RESULTADOS: O gênero não influenciou o IMC, a pressão arterial sistólica (PAS) e diastólica (PAD). A idade variou de 18 a 56 anos. Não foi observada correlação entre aumento da idade e maior IMC ou pressão arterial. 86 indivíduos (88,7%) apresentaram PA normal, 11 (11,3%) pré-hipertensão e nenhum hipertensão. Vinte (20,4%) apresentaram PA inferior a 90 × 60 mmHg. O IMC variou entre 18 e 48 kg/m 2 (média de 28,8 ± 3,92), 21,9% tinham peso normal, 40,7% sobrepeso, 25,3% obesidade grau I, 9,9 % grau II e 2,2% obesidade grau III. Aumento significativo da PAS e PAD foi associado com elevação do IMC (P = 0,0175 e P = 0,0015). CONCLUSÃO: Verificou-se que sexo e idade não influenciaram PAS, PAD e IMC em adultos brasileiros com SD. O aumento significativo da PAS e PAD foi associado com o aumento do IMC.

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“…This explains why shear stress cannot explain atherosclerosis resistance in Down's Syndrome [576,577], hemophilia, von Willebrand coagulopathy [578], and patients treated with anticoagulants.…”

Section: Inflammation and Atherosclerosismentioning

confidence: 99%

Stress repair mechanism activity explains inflammation and apoptosis

Coleman¹

2012

ABB

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Comparison of Intima-Media Thickness of the Carotid Artery and Cardiovascular Disease Risk Factors in Adults With Versus Without the Down Syndrome

Cited by 62 publications

References 16 publications

Down Syndrome and Vascular Disease: DSCR1 and NFAT Signaling

Down Syndrome and Vascular Disease: DSCR1 and NFAT Signaling

Blood pressure levels and body mass index in Brazilian adults with Down syndrome

Stress repair mechanism activity explains inflammation and apoptosis

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