Comparison of Intrathecal Buprenorphine Versus Clonidine as an Adjuvant to 0.5% Hyperbaric Bupivacaine in Lower Abdominal Surgeries

Bafna, Usha; Yadav, Hiteshi; Sharma, Neelu

doi:10.32553/ijmbs.v4i4.1074

Cited by 5 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regional analgesia has shown to improve surgical outcomes by decreasing intraoperative blood loss, postoperative catabolism, the incidence of thromboembolic events and by improving vascular graft blood flow and postoperative pulmonary function [2].Spinal anaesthesia is a commonly used regional anaesthesia technique for lower limb and lower abdominal surgeries owing to its well-known advantages like quick onset, excellent sensory and motor block and avoidance of complications of general anaesthesia [3]. The discovery of opioid receptors in the brain and spinal cord started a new era in the field of postoperative analgesia [4].…”

Section: Discussion:-mentioning

confidence: 99%

A Comparision of Intrathecal Hyperbaric Bupuvacaine With Buprenorphine and Hyperbaric Bupivacaine Alone in Gynaecological Surgeries for Postoperative Analgesia

Jadhav¹,

Bengali²

2021

IJAR

View full text Add to dashboard Cite

This study was performed at a tertiary care centre after the approval of the Institutional Ethical Committee and obtaining written informed consent from all patients. Sixty ASA I and II, aged 18- 65yrs, bodyweight 45-70kgs scheduled for gynaecological surgeries under spinal anaesthesia were chosen for the study and were divided into two groups named Group B and Group BN each comprising 30 patients. Group B received 3ml of 0.5% hyperbaric bupivacaine with 0.5 ml normal saline and Group BN received 3ml of 0.5% hyperbaric bupivacaine with 0.5ml (150mcg) of buprenorphine. Vital parameters like pulse rate, blood pressure, respiratory rate, SpO2 were recorded at 0 (basal) 15, 30, 45, 90 and 180 minutes. Postoperatively heart rate, blood pressure, respiratory rate and SP02 were monitored at 3 ,6 ,12 and 24 hrs. The mean age, height, weight, duration of surgery were comparable. Time of onset of sensory blockade and motor blockade were noted. The time for rescue medication was 909.0Â±216.9 min in group BN with a range from 690 min to 1500 min and in group B it was 412.0Â±89.28 min with a range from 130 min to 195 min. Comparing both groups duration of effective analgesia was significantly higher in group BN with P<0.0001.thus, it can be concluded that addition of buprenorphine as an adjuvant in spinal anaesthesia excellently prolongs duration of analgesia in postoperative period with minimal side effects.

show abstract

Section: Discussion:-mentioning

confidence: 99%

A Comparision of Intrathecal Hyperbaric Bupuvacaine With Buprenorphine and Hyperbaric Bupivacaine Alone in Gynaecological Surgeries for Postoperative Analgesia

Jadhav¹,

Bengali²

2021

IJAR

View full text Add to dashboard Cite

show abstract

“…Pain is defined as an unpleasant sensory or emotional experience associated with actual or potential tissue damage or described in terms of such damage. [ 1 2 ] Pain following surgical trauma remains a major problem for anesthetists and management of pain warrants more evidence. The objective of postoperative management is to prolong the sensory block without affecting the rate of motor block recession.…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Doses of Buprenorphine in Combination with Bupivacaine in the Management of Postoperative Analgesia

Biswal

Borkotoky

Karan

et al. 2022

Anesthesia Essays &Amp; Researches

View full text Add to dashboard Cite

Background: Longer duration of analgesia, ceiling effect on respiratory depression, and the antihyperalgesia property make buprenorphine a good adjuvant for managing moderate-to-severe postoperative pain. Aims: The aim of this study is to evaluate the onset and duration of postoperative analgesia of three different doses of buprenorphine of 60, 100, and 150 μg given intrathecally along with hyperbaric bupivacaine in patients undergoing lower limb surgeries. Setting and Design: This prospective observational study was carried out in the anesthesia department of a tertiary care hospital. Materials and Methods: The study included 90 patients of either sex, aged 18–60 years, scheduled for elective lower limb surgery under subarachnoid block. Patients were randomly allocated into three groups (30 each) receiving different doses of buprenorphine. In addition, all patients received 3 mL of 0.5% hyperbaric bupivacaine. Statistical Analysis Used: The Chi-square test or Fisher's exact test was used to find out the association between the categorical variables. The association of quantitative variables between the groups was assessed by Kruskal–Wallis test while within the groups was assessed by repeated-measures analysis of variance test. Results: Baseline characteristics such as age, gender, and American Society of Anesthesiologist physical status classification were comparable among the three groups. Sensory block, motor block, and total duration of analgesia were significantly higher with higher doses of buprenorphine. The mean difference in the duration of analgesia was comparable in patients receiving 100 μg (720 min) and 150 μg (825 min) of buprenorphine. Bradycardia as a side effect was only in patients receiving 150 μg of buprenorphine. Conclusion: Risk–benefit of different doses of buprenorphine suggests that 100 μg may be the ideal dose for a better quality of spinal block and maintaining hemodynamic stability.

show abstract

Buprenorphine with Bupivacaine 0.5% Heavy Versus Clonidine with Bupivacaine 0.5% Heavy Versus Bupivacaine 0.5% Heavy Alone in Patients Undergoing Total Abdominal Hysterectomy: A Comparative Study

Thankaraj,

Pranavadhyani,

Chandrasekaran

2024

Apollo Medicine

View full text Add to dashboard Cite

Background and Aims: This research aimed to determine which of three spinal anaesthetic medication combinations—clonidine–bupivacaine, buprenorphine–bupivacaine and bupivacaine alone—is the most effective for total abdominal hysterectomy. Material and Methods: In this prospective study, approved by the Institutional Ethical Committee, 120 patients aged 35–60 years scheduled for elective total abdominal hysterectomy under spinal anaesthesia were included, following informed consent. Comprehensive pre-anaesthetic assessments, including detailed medical histories, clinical examinations and routine surgical investigations, were conducted. The study, spanning 24 months, utilised purposive sampling and a cross-sectional design. The inclusion criteria encompassed ASA I and II patients aged 35–60 years, undergoing elective total abdominal hysterectomy with a weight exceeding 45 kg, height over 150 cm, and valid informed consent. Exclusion criteria involved ASA Class III or higher, patient unwillingness for spinal anaesthesia, gross spinal deformities, bleeding diathesis, known allergy to the test drug, history of cardiac, respiratory, or central nervous system disease, hepatic or renal dysfunction and elevated intracranial pressure. Results: The onset time of sensory blockade was faster in the Bupivacaine + Buprenorphine group than in the Clonidine + Bupivacaine group, with the Bupivacaine group exhibiting the slowest onset. The Bupivacaine + Buprenorphine group had a significantly faster onset of motor block than the Clonidine + Bupivacaine and Bupivacaine groups. The total duration of motor block was shorter in both the Bupivacaine + Buprenorphine and Bupivacaine groups than in the Clonidine + Bupivacaine group. The Clonidine + Bupivacaine group showed higher incidences of bradycardia and hypotension than the other groups. The Bupivacaine + Buprenorphine group reported more side effects, including chest pain, cough, nausea and vomiting, than the other groups. Conclusion: This study found that spinal clonidine, in comparison to bupivacaine alone, gives better post-operative analgesia and sensory and motor blockage over a longer period of time.

show abstract

Comparison of Intrathecal Buprenorphine Versus Clonidine as an Adjuvant to 0.5% Hyperbaric Bupivacaine in Lower Abdominal Surgeries

Cited by 5 publications

References 10 publications

A Comparision of Intrathecal Hyperbaric Bupuvacaine With Buprenorphine and Hyperbaric Bupivacaine Alone in Gynaecological Surgeries for Postoperative Analgesia

A Comparision of Intrathecal Hyperbaric Bupuvacaine With Buprenorphine and Hyperbaric Bupivacaine Alone in Gynaecological Surgeries for Postoperative Analgesia

Effect of Different Doses of Buprenorphine in Combination with Bupivacaine in the Management of Postoperative Analgesia

Buprenorphine with Bupivacaine 0.5% Heavy Versus Clonidine with Bupivacaine 0.5% Heavy Versus Bupivacaine 0.5% Heavy Alone in Patients Undergoing Total Abdominal Hysterectomy: A Comparative Study

Contact Info

Product

Resources

About