Comparison of intrathecal hyperbaric bupivacaine and levobupivacaine with fentanyl for caesarean section

Subasi, D.; Ekinci, Osman; Kuplay, Yıldız Yiğit; Müftüoğlu, Tolga; Terzioĝlu, Berna

doi:10.5222/j.goztepetrh.2012.022

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…It is generally known that hyperbaric solutions increase peak levels but may also cause more bouts of bradycardia and hypotension. [20].…”

Section: Discussionmentioning

confidence: 99%

Comparison of 0.5% isobaric Levobupivacaine with 0.5% hyperbaric Bupivacaine in patients undergoing lower abdominal surgeries

Bekkam¹,

Bano²,

Chandrika³

et al. 2022

ijhs

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Background: Since more than a century ago, spinal anaesthesia has been a preferred approach for lower abdominal procedures. Local anaesthetics are selected primarily based on onset, duration, strength of sensory and motor block, and side effects. The aim of our study was to compare sensory and motor block characteristics, hemodynamic changes, and side effects following isobaric levobupivacaine (0.5%) and hyperbaric Bupivacaine (0.5%) in elective lower abdominal surgeries under spinal anesthesia. Materials and methods: A randomized, double‑blind study was carried out on 60 patients of either sex, aged 18-60 years, ASA grade I or II scheduled for elective lower abdominal surgeries. Patients were divided into two groups of 30 patients each. Group L received 3 ml of 0.5% levobupivacaine, and Group B received 3 ml of 0.5% bupivacaine. We observed the characteristics of the sensory and motor blockade & side effects in both groups. Results: The mean time of onset of sensory block was 12.68±0.6 minutes in group L, while 7.22±0.7 minutes in group B. The mean time for total duration of sensory block was 211.1±8.2 minutes in group L, while 183.13±13.7 minutes in group B.

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“…It is generally known that hyperbaric solutions increase peak levels but may also cause more bouts of bradycardia and hypotension. [20].…”

Section: Discussionmentioning

confidence: 99%

Comparison of 0.5% isobaric Levobupivacaine with 0.5% hyperbaric Bupivacaine in patients undergoing lower abdominal surgeries

Bekkam¹,

Bano²,

Chandrika³

et al. 2022

ijhs

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“…1 Dalam sebuah studi lainnya tidak ada perbedaan yang signifikan antara waktu regresi dua segmen pada kedua kelompok (p> 0,05) dengan rata-rata waktu regresi 2 segmen menjadi 89,95 menit pada kelompok levobupivacain dan 82,74 menit pada kelompok levobupivacain ini mungkin disebabkan oleh penggunaan levobupivacain hiperbarik dan bupivacaine hiperbarik dibandingkan dengan levobupivacain isobarik. 11 Penelitian yang dilakukan pada tahun 2006, membandingkan efektivitas klinis serta keamanan klinis antara levobupivacain isobarik dengan bupivakain hiperbarik. 9 Waktu pulih ditandai dengan dapat merasakan sensasi dermatom sakral 1 (S1) levobupivacain 256,2 (48,1) menit dan bupivakain 215,1 (50,8) menit dengan p-value 0,83 (p<0,05).…”

Section: Pembahasanunclassified

Perbandingan Efek 10 Mg dengan 12,5 Mg Levobupivacain 0,5% Isobarik terhadap Onset, Durasi, dan Hemodinamik pada Spinal Anestesi untuk Seksio Sesarea

Ismail

Ahmad

Musba

2020

JAOI

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Latar Belakang: Tujuan utama spinal anestesi pada seksio sesarea adalah meminimalkan efek samping pada ibu dan bayi baru lahir. Levobupivacain memiliki mekanisme aksi yang sama dengan anestesi lokal lainnya, akan tetapi memiliki efek toksik pada jantung dan saraf yang lebih kecil. Tujuan: Membandingkan onset/durasi blok sensorik, motorik serta hemodinamik antara 10 Mg dengan 12,5 Mg Levobupivacain 0,5% Isobarik + fentanyl 25 μg pada seksio sesarea dengan anestesi spinal.Metode: Sampel terdiri dari dua kelompok, kelompok pertama menerima 10 Mg Levobupivacain 0,5% Isobarik + fentanyl 25 μg dan kelompok kedua menerima 12,5 Mg Levobupivacain 0,5% Isobarik + fentanyl 25 μg dengan sampel masing-masing kelompok 23 orang. Analisis data menggunakan uji statistik uji T independen.Hasil: Onset blok sensorik lebih cepat pada kelompok 12,5 Mg Levobupivacain (2,30 menit) dibandingkan kelompok 10 Mg Levobupivacain (3,70 menit), hal ini secara statistik menunjukkan perbedaan yang signifikan. Durasi blok sensorik kelompok 12,5 Mg Levobupivacain (187,39 menit), durasi blok motorik (194,57 menit) lebih lama dibandingkan kelompok 10 Mg Levobupivacain durasi blok sensorik (153,48 menit) dan durasi blok motorik (157,83 menit). Tidak ada perbedaan yang signifikan pada perubahan hemodinamik untuk kedua kelompokSimpulan: Onset blok sensorik kelompok 12,5 Mg Levobupivacain lebih cepat dibandingkan kelompok 10 Mg Levobupivacain, durasi blok sensorik dan blok motorik kelompok 12,5 Mg Levobupivacain lebih lama dibandingkan kelompok 10 Mg Levobupivacain. Comparison Effects 10 Mg with 12.5 Mg Levobupivacain 0.5% Isobaric Against Onset, Duration, and Hemodynamics in Spinal Anesthesia of Caesarean Section Abstract Background: The main purpose of spinal anesthesia in cesarean section is to minimize side effects on the mother and newborn baby. Levobupivacaine has the same mechanism of action as other local anesthetics, but has a smaller toxic effect on the heart and nerves.Objective: Comparing the onset / duration of sensory, motor and hemodynamic blocks between 10 Mg and 12.5 Mg Levobupivacain 0.5% Isobaric + 25 μg fentanyl in cesarean section with spinal anesthesia.Methods: The sample consisted of two groups, the first group received 10 Mg Levobupivacain 0.5% Isobaric + fentanyl 25 μg and the second group received 12.5 Mg Levobupivacain 0.5% Isobaric + fentanyl 25 μg with a sample of 23 people each group. Data analysis using independent T test statistical tests.Results: Sensory block onset was faster in the 12.5 Mg Levobupivacain group (2.30 minutes) than the 10 Mg Levobupivacain group (3.70 minutes), this statistically showed a significant difference. The sensory block duration of the 12.5 Mg Levobupivacain group (187.39 minutes), the motor block duration (194.57 minutes) is longer than the 10 Mg Levobupivacain group the duration of the sensory block (153.48 minutes) and the duration of the motor block (157.83 minutes). There were no significant differences in hemodynamic changes for the two groups.Conclusion: The onset of the 12.5 Mg Levobupivacain sensory block was faster than the 10 Mg Levobupivacain group, the duration of the sensory block and motor block of the 12.5 Mg Levobupivacain group was longer than the 10 Mg Levobupivacain group

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A Comparison of Spinal Anaesthesia With Levobupivacaine and Hyperbaric Bupivacaine Combined With Fentanyl in Caesarean Section

Kalepalli¹

2016

jebmh

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BACKGROUND Recent trends in obstetric anaesthesia show increased popularity of regional anaesthesia among obstetric anaesthetists. General anaesthesia in caesarean section is associated with high morbidity and mortality rate when compared with regional anaesthesia. Regional anaesthesia has its own demerits which are primarily related to excessively high spinal blocks and toxicity of local anaesthetics. Reduction in doses and improvement in technique to avoid high level blocks and increased awareness of toxicity of local anaesthetics have contributed to reduction in complications related to regional anaesthesia. The challenges presented by a parturient requiring anaesthesia or analgesia, or both, make the role of obstetric anaesthesiologist both challenging and rewarding. Spinal anesthesia is a popular technique for caesarean delivery. Hyperbaric Bupivacaine in 8% glucose is often used. Plain or glucose-free, Bupivacaine has been frequently referred to as "Isobaric" in the literature, even after Blomqvist and Nilsson demonstrated its hypobaricity. More recently, several studies have confirmed that plain Bupivacaine is indeed hypobaric in comparison with human CSF. Although hyperbaric local anesthetic solutions have a remarkable record of safety, their use is not totally without risk. To prevent unilateral or saddle blocks, patients should move from the lateral or sitting position rapidly to supine position. Hyperbaric solutions may cause sudden cardiac arrest after spinal anesthesia because of the extension of the sympathetic block. The use of truly isobaric solutions may prove less sensitive to position issues. Hyperbaric solutions may cause hypotension or bradycardia after mobilization. Isobaric solutions are favored with respect to their less sensitivity to postural changes. MATERIALS AND METHODS 60 full term parturients of ASA Grade 1 and 2 posted for elective caesarean section under spinal anaesthesia were divided in to two groups. GROUP LF (n = 30)-Received 1.8 ml (9 mg) Levobupivacaine 0.5% + Fentanyl 10 mcg (0.2 ml). GROUP BF (n = 30)-Received 1.8 ml (9 mg) hyperbaric Bupivacaine 0.5% + Fentanyl 10 mcg (0.2 ml). The parameters measured in the two groups included haemodynamic measurements (Pulse rate, systolic blood pressure, diastolic blood pressure), respiratory parameters (Respiratory rate, oxygen saturation) characteristics of sensory block, characteristics of motor block, intra operative and post-operative complications like nausea, vomiting, shivering, visceral pain, sedation. In the neonate, Apgar score was measured to assess any effects of drugs the neonate. RESULTS Hypotension and bradycardia was more in hyperbaric Bupivacaine group (BF). Time for Onset of sensory block and maximum dermatome level reached were similar in both groups. Time for maximum sensory level reached, two segment regression time, T12 regression time and time for first analgesic requirement were early in LF group. Onset of motor block was delayed in LF group. Maximum degree of motor block was same in both groups (Bromage 3). Co...

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Comparison of intrathecal hyperbaric bupivacaine and levobupivacaine with fentanyl for caesarean section

Cited by 4 publications

References 26 publications

Comparison of 0.5% isobaric Levobupivacaine with 0.5% hyperbaric Bupivacaine in patients undergoing lower abdominal surgeries

Comparison of 0.5% isobaric Levobupivacaine with 0.5% hyperbaric Bupivacaine in patients undergoing lower abdominal surgeries

Perbandingan Efek 10 Mg dengan 12,5 Mg Levobupivacain 0,5% Isobarik terhadap Onset, Durasi, dan Hemodinamik pada Spinal Anestesi untuk Seksio Sesarea

A Comparison of Spinal Anaesthesia With Levobupivacaine and Hyperbaric Bupivacaine Combined With Fentanyl in Caesarean Section

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