Comparison of intrathecal isobaric bupivacaine–morphine and ropivacaine–morphine for Caesarean delivery † †Presented at the 2nd World Congress of the World Institute of Pain, I˙stanbul, Turkey, June 2001.

Öğün, Cemile Öztin; Kirgiz, Esma Nur; Duman, Ateş; Ökesli, Selmin; Akyürek, Cemalettin

doi:10.1093/bja/aeg123

Cited by 55 publications

(13 citation statements)

References 20 publications

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“…Ogun et al [19] found that intrathecal isobaric ropivacaine 0.5% 15 mg with morphine 150 µg provided sufficient anaesthesia for caesarean delivery. The parturients were compared with the bupivacaine group.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of fentanyl and morphine in addition to hyperbaric or isobaric bupivacaine in combined spinal anaesthesia for caesarean section

Saraçoğlu¹,

Saraçoğlu²,

Etı³

2011

aoms

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IntroductionThe aim of our study was to compare the effects of isobaric and hyperbaric bupivacaine combined with morphine or fentanyl in patients undergoing caesarean section. We assessed quality and spread of analgesia and anaesthesia, postoperative analgesic requirement and side effects.Material and methodsHundred patients with American Society of Anesthesiologists physical status (ASA) I-II, age 18 to 40 years, were randomized to 4 groups. The intrathecal solutions were isobaric bupivacaine + morphine (group A), isobaric bupivacaine + fentanyl (group B), heavy bupivacaine + + morphine (group C) and heavy bupivacaine + fentanyl (group D). Mean arterial pressure, heart rate, oxygen saturation, ephedrine consumption, analgesic requirement time and additional analgesic needs were recorded.ResultsThe 1st min value of mean arterial pressure was the lowest one in all groups. Heart rate decreased significantly in group A at the 10th min but not in the other groups. The decrease of visual analogue scale (VAS) pain scores began in the groups after the 4th postoperative h (p < 0.05) and the VAS value of group B at the 8th h was significantly higher than the other groups. The first analgesic requirement time in the postoperative period was longer in patients who had intrathecal morphine than those who had fentanyl. The duration of analgesia with isobaric bupivacaine and morphine was the longest one.ConclusionsWe concluded that intrathecal morphine provides a long duration of postoperative analgesia but the duration gets longer when it is combined with plain bupivacaine instead of heavy bupivacaine.

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Section: Discussionmentioning

confidence: 99%

Comparative study of fentanyl and morphine in addition to hyperbaric or isobaric bupivacaine in combined spinal anaesthesia for caesarean section

Saraçoğlu¹,

Saraçoğlu²,

Etı³

2011

aoms

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“…The median dosage of 0.5% Hyperbaric Bupivacaine was significantly low of 9(8.5-9.5 [7.5-11])mg in CD group in comparison to 11 mg in FD group. The median time to reach T6 sensory block 2(2-3[1-6]) minutes in Group FD was much early in comparison to 4(3-5) [1][2][3][4][5][6][7][8][9][10][11][12]) minutes in Group CD. The median maximum sensory level achieved in 20 minutes T3(T3-T4[T2-T5]) in Group FD was also significant in comparison to T5(T4-T5[T3-T5]).…”

Section: Figure 1: Consort Flow Diagrammentioning

confidence: 99%

“…The values are statistically significant with p-value <0.05. The median time to motor blockage Bromage-III was relatively early 4(3-6 [1][2][3][4][5][6][7][8][9][10][11][12])minutes in Group FD in comparison to 6(5-8 [2][3][4][5][6][7][8][9][10][11][12][13][14]) minutes in Group CD with a p-value of <0.05. Two parturient (4.5%) in Group CD needed head down position in order to get the desired level of sensory block.…”

Section: Figure 1: Consort Flow Diagrammentioning

confidence: 99%

“…Bradycardia in 3 (6.8%) and Vomiting in 2 (4.5%) were also noted in Group FD parturient. The median dose of mephentermine consumed 12 (9-18[6-18]) mg in Group FD was statistically significant in comparison to 6(6-9 [1][2][3][4][5][6][7][8][9][10][11][12]) mg in Group CD.…”

Section: Figure 1: Consort Flow Diagrammentioning

confidence: 99%

“…Spinal anesthesia with hyperbaric bupivacaine is the preferred anesthetic technique for cesarean deliveries 1 .The incidence of hypotension following spinal anesthesia for cesarean section is high with trials reporting as high as 80%. 2 .…”

Section: Introductionmentioning

confidence: 99%

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Fixed-dose versus height and weight-adjusted dose of intrathecal 0.5% hyperbaric bupivacaine in elective cesarean section: A comparative study

Kumar¹,

Shrestha²,

Shrestha³

2020

J. Soc. Anesth. Nep.

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Background: Spinal anesthesia is the preferred anesthetic technique for cesarean deliveries. But there is a dosage dilemma regarding block to the desired level and preventing hypotension. We aim to study effects of fixed dose with height and weightadjusted dose of intrathecal 0.5% hyperbaric bupivacaine during elective cesarean section. Methods: Eighty-eight singleton term parturients were enrolled and divided into two groups, Group FD (Fixed Dose) and CD (Calculated Dose) in this prospective, double-blind, randomized controlled trial. Group FD received 2.2 ml and CD received a height and weight adjusted calculated dose based on Harten's chart. Hemodynamic changes, onset time to sensory block to T6, maximum block in 20 minutes, and adverse effects were compared. Results: There was a significant reduction in median drug dosage of 11mg in FD versus 9 mg in CD group. The decrease in the MAP was less in group CD (14.5±2.98) mmHg compared to (17.6±4.66) mmHg in group FD (P= 0.03). The median onset time of spinal block to T6 in group FD of 2 minutes with IQR (2-3) was faster than Group CD 4 minutes with IQR (3-5). The spinal block extended above T4 in the larger number of parturients 23 (52 %) in Group FD than in three (6.8%) in group CD (p<0.05).Significantly larger number 20 (45.45 %) in group FD developed hypotension than seven (15.9 %) in Group CD. Bradycardia and vomiting were also found in group FD. Conclusions: This calculated dose provided the desired level of the spinal block and also restricted spinal block level with a distinct advantage of less hypotension.

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Obstetric Anesthesiology

Paschall

2011

Essentials of Regional Anesthesia

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Comparison of intrathecal isobaric bupivacaine–morphine and ropivacaine–morphine for Caesarean delivery † †Presented at the 2nd World Congress of the World Institute of Pain, I˙stanbul, Turkey, June 2001.

Abstract: Intrathecal isobaric ropivacaine 0.5% 15 mg plus morphine 150 micro g provides sufficient anaesthesia for Caesarean delivery. The ropivacaine-morphine combination resulted in shorter motor block, similar sensory and postoperative analgesia.

Cited by 55 publications

References 20 publications

Comparative study of fentanyl and morphine in addition to hyperbaric or isobaric bupivacaine in combined spinal anaesthesia for caesarean section

Comparative study of fentanyl and morphine in addition to hyperbaric or isobaric bupivacaine in combined spinal anaesthesia for caesarean section

Fixed-dose versus height and weight-adjusted dose of intrathecal 0.5% hyperbaric bupivacaine in elective cesarean section: A comparative study

Obstetric Anesthesiology

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