Comparison of intratympanic steroid treatment versus hemodilution and vasoactive treatment combination in sudden hearing loss

Aydın, Sedat; Şanlı, Arif; Altın, Gökhan; Eken, Mehmet; Yılmaz, Süleyman

doi:10.5505/jkartaltr.2011.18199

Cited by 1 publication

(1 citation statement)

References 13 publications

(14 reference statements)

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“…Aydın et al reported that IT-MP had better hearing results compared to combined therapy (intravenous dextran and oral pentoxyfilline). 24 They administered 5 intratympanic injections regardless of the hearing results. We took PTA into consideration for deciding to continue the injections.…”

Section: Discussionmentioning

confidence: 99%

Intratympanic Methyl Prednisolone Salvage Therapy for Sudden Hearing Loss

Hıdır¹,

Genç²,

Durmaz³

et al. 2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of the study was to determine effectiveness of intratympanic methyl prednisolone injection as a salvage therapy for sudden sensorineural hearing loss in patients who did not have complete recovery with systemic treatment. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: Sixteen patients with sudden hearing loss who did not have complete recovery or had a partial recovery with systemic treatment enrolled in this prospective study. After the topical anesthesia, 0.4-0.5 mL of methyl prednisolone (40 mg/mL) was administered into the middle ear from the postero-inferior quadrant of the tympanic membrane. Pure tone audiometry test was performed before each injection and after the final injection. A change more than 10 dB in the pure tone average was considered as an alteration in hearing (improvement or worsening). Complete recovery was accepted when the pure tone average was 20 dB or lower. R Re es su ul lt ts s: : The mean onset of intratympanic methyl prednisolone treatment after the hearing loss was 16±6.6 days (range: 7 -30 days). The average number of injections was 3.8±1.3 (range: 2-6). The improvement in pure tone average was statistically significant [initial median of pure tone average was 85 dB (minimum 28 dB, maximum 107 dB), final median of pure tone averages was 42.5 dB (minimum 12 dB, maximum 107dB), p=0.007]. Eleven (68.75%) patients improved, but no change was observed in 5 (31.25%) patients. Two (12.5%) patients attained complete recovery. Four (25%) patients improved to 30 dB or less in pure tone average. Statistically significant improvement was also obtained at 250, 500, 1,000, 2,000, 4,000 and 6,000 Hz frequencies. C Co on nc cl lu us si io on n: : These results suggested that intratympanic methyl prednisolone treatment for sudden hearing loss in patients who did not respond to systemic therapy appears to be a good alternative for better hearing results. K Ke ey y W Wo or rd ds s: : Hearing loss, sudden; methylprednisolone; salvage therapy; steroids Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı, sistemik tedaviye yeterli yanıt alınamayan ani işitme kayıplı hastalarda kurtarma tedavisi olarak uygulanan intratimpanik metil prednizolon tedavisinin etkinliğini araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu prospektif çalışmaya, sistemik tedaviye yanıt alınamayan veya kısmi yanıt alınan 16 ani işitme kayıplı hasta alındı. Topikal anestezi sonrasında 0,4-0,5 mL metil prednizolon (40 mg/mL), timpanik membran posteroinferior kadranından orta kulağa enjekte edildi. Her enjeksiyon öncesinde ve tedavi sonunda saf ses odyometri testi yapıldı. Saf ses ortalamasında 10 desibelden daha fazla değişiklik, değişim olarak kabul edildi (iyileşme veya kötüleşme). Saf ses ortalamasının 20 dB ve daha aşağıdaki değerleri tam iyileşme olarak kabul edildi. B Bu ul lg gu ul la ar r: : İşitme kaybı başlangıcı ile intratimpanik metil prednizolon uygulaması arasındaki ortalama süre 16±6,6 gündü (7-30 gün arasında). Ortalama en...

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Section: Discussionmentioning

confidence: 99%