Osteoarthritis is the most prevailing disorder in elderly people affecting their quality of life and reducing mobility. Objective: To compare the efficacy of mini squats and endurance training in improving the quality of life in knee osteoarthritis. Methods: After receiving the approval from ERC of The Neuro-counsel Clinic, the current RCT sample size was 30 participants calculated by Epitool, from 16 May 2023 to 15 September 2023 and executed at The Neurocounsel Clinics/Hospital. Both genders between the ages of 40-65 years old with OA of grade 2-3 on the R&L scale were included in this study. Those participants who had pain greater than 8 on PNS along with serious comorbidity were excluded from this study. Two equal groups were formed. Group A was given mini squats at the rate of two sets each containing 10 squats. Group B was given endurance training by use of a therapeutic band using quadriceps sets. 3x/week for 4 weeks were given to each group. The assessment was made based on the WOMAC scale & and SF-36 QoL. The level of significance was kept at <0.05. Results: Within groups analysis of the WOMAC scale, revealed that both interventions showed marked improvement with p<0.05. However, group analysis also showed a significant difference as p<0.05 on quality of life and WOMAC Scale. Conclusions: It was revealed that mini squats are more effective in improving knee OA quality of life as compared to endurance training by the use of a therapeutic band.