Comparison of laboratory parameters between children with and without febrile convulsion

Abstract

Background/Aim: Febrile convulsion is the most common central nervous system disease of childhood. The etiology of febrile convulsion is not fully brightened. In this study, we aimed to evaluate the relationship between hemogram, biochemical and hormonal parameters and febrile convulsion, and the roles of laboratory parameters in its etiopathogenesis. Methods: A total of fifty-four patients diagnosed with febrile convulsion in the pediatric neurology outpatient clinic of a tertiary hospital from October 2017 to December 2018 were included in this retrospective cohort study. Age, sex, age of first convulsion, type of convulsion and laboratory parameters of the patients were recorded. ILAE classification system was used for the diagnosis of febrile convulsion. Febrile convulsion patients were included in the study group, while the control group was randomly selected from patients between 6 months and 6 years of age who visited general pediatric outpatient clinic. Results: A total of 54 patients (30 males, 24 females) in the study group and 82 patients (53 males, 29 females) in the control group were included in the study (P=0.288). The mean ages of the patients in the study and control groups were 30.31 (14.64) months and 32.32 (19.70) months, respectively (P=0.524). Mean platelet volume (MPV), platelet count, 25-OH D3, vitamin B12 and phosphorus values were significantly lower in the study group (P<0.001, P=0.013, P=0.017, P=0.020). Conclusion: MPV, platelet count, 25 OH D3, vitamin B12 lower levels may be risk factors for febrile convulsion. Studies related to the etiopathogenesis of febrile convulsion are necessary to enlighten the subject and laboratory results will be the guide in this sense.

The relationship between febrile seizure and hematological parameters in children

“…In the study of Aydın et al, a significant difference was observed in the MPV value of patients with febrile seizures compared to the healthy control group without fever and seizure. 25 The principal limitations of this study are the low case numbers, its retrospective nature, and the fact that the research employed the hospital database. Further prospective studies with wider population-based case series are now needed to elicit more detailed results.…”