“…In a meta-analysis of 24 268 patients with multivessel CAD treated with CABG or DES, 80 the incidences of death and MI were similar for the 2 procedures, but the frequency with which repeat revascularization was performed was roughly 4 times higher after DES implantation. Only 1 large RCT comparing CABG and DES implantation has been 66,81,82 Major adverse cardiac and cerebrovascular events (MACCE)-a composite of death, stroke, MI, or repeat revascularization during the 3 years after randomization-occurred in 20.2% of patients who had received CABG and 28.0% of those who had undergone DES implantation (P<0.001). The rates of death and stroke were not significantly different; however, MI (3.6% for CABG, 7.1% for DES) and repeat revascularization (10.7% for CABG, 19.7% for DES) were more likely to occur with DES implantation.…”