Comparison of left ventricular ejection fraction by magnetic resonance imaging and radionuclide ventriculography in idiopathic dilated cardiomyopathy

Gaudio, Carlo; Tanzilli, Gaetano; Mazzarotto, Pietro; Motolese, M; Romeo, Francesco; Marino, Benedetto; Reale, A

doi:10.1016/0002-9149(91)90051-l

Cited by 49 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After intensification, maximum LVEF values were significantly higher than before intensification in patients treated by subcutaneous and intravenous DFO (P Ͻ .0001). [42][43][44] which also has excellent reproducibility. Recently, MRI techniques have been used to estimate myocardial iron and, by inference, cardiac risk.…”

Section: Discussionmentioning

confidence: 93%

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major

Davis

O’Sullivan

Jarritt

et al. 2004

Blood

160

133

View full text Add to dashboard Cite

Regular monitoring of left ventricular ejection fraction (LVEF) for thalassemia major is widely practiced, but its informativeness for iron chelation treatment is unclear. Eighty-one patients with thalassemia major but no history of cardiac disease underwent quantitative annual LVEF monitoring by radionuclide ventriculography for a median of 6.0 years (interquartile range, 2-12 years). Intraobserver and interobserver reproducibility for LVEF determination were both less than 3%. LVEF values before and after transfusion did not differ, and exercise stress testing did not reliably expose underlying cardiomyopathy. An absolute LVEF of less than 45% or a decrease of more than 10 percentage units was significantly associated with subsequent development of symptomatic cardiac disease (P < .001) and death (P ‫؍‬ .001), with a median interval between the first abnormal LVEF findings and the development of symptomatic heart disease of 3.5 years, allowing time for intervention. In 34 patients in whom LVEF was less than 45% or decreased by more than 10 percentage units, intensified chelation therapy was recommended (21 with subcutaneous and 13 with intravenous deferoxamine). All 27 patients who complied with intensification survived, whereas the 7 who did not comply died (P < .0001). The KaplanMeier estimate of survival beyond 40 years of age for all 81 patients is 83%. Sequential quantitative monitoring of LVEF is valuable for assessing cardiac risk and for identifying patients with thalassemia major who require intensified chelation

show abstract

Section: Discussionmentioning

confidence: 93%

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major

Davis

O’Sullivan

Jarritt

et al. 2004

Blood

160

133

View full text Add to dashboard Cite

show abstract

“…There are, however, various shortcomings in using echocardiography [31], ventriculography [22], angiography [33] and indicator-dilution methods [13] compared with magnetic resonance imaging (MRI).…”

Section: Introductionmentioning

confidence: 99%

A curvature-based approach for left ventricular shape analysis from cardiac magnetic resonance imaging

Yeo

Zhong

et al. 2008

Med Biol Eng Comput

View full text Add to dashboard Cite

It is believed that left ventricular (LV) regional shape is indicative of LV regional function, and cardiac pathologies are often associated with regional alterations in ventricular shape. In this article, we present a set of procedures for evaluating regional LV surface shape from anatomically accurate models reconstructed from cardiac magnetic resonance (MR) images. LV surface curvatures are computed using local surface fitting method, which enables us to assess regional LV shape and its variation. Comparisons are made between normal and diseased hearts. It is illustrated that LV surface curvatures at different regions of the normal heart are higher than those of the diseased heart. Also, the normal heart experiences a larger change in regional curvedness during contraction than the diseased heart. It is believed that with a wide range of dataset being evaluated, this approach will provide a new and efficient way of quantifying LV regional function.

show abstract

“…If significant PR is found, cardiac MRI is performed to quantify PR severity and RV function (20). Many studies have shown that MRI is the best and most comprehensive approach to quantify the three dimensional (3-D) ventricular geometry and function (4,25,(47)(48), compared with echocardiography (16,41), ventriculography (14,46), angiography (33), and indicator-dilution methods (10). In patients with demonstrable severe PR and borderline RV function, serial MRI assessment becomes mandatory for timing of pulmonary valve replacement (PVR; Ref.…”

mentioning

confidence: 99%

Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot

Zhong

Gobeawan

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Tan RS, Kassab G. Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot. Am J Physiol Heart Circ Physiol 302: H1306 -H1316, 2012. First published December 30, 2011 doi:10.1152/ajpheart.00679.2011.-A quantitative understanding of right ventricular (RV) remodeling in repaired tetralogy of Fallot (rTOF) is crucial for patient management. The objective of this study is to quantify the regional curvatures and area strain based on three-dimensional (3-D) reconstructions of the RV using cardiac magnetic resonance imaging (MRI). Fourteen (14) rTOF patients and nine (9) normal subjects underwent cardiac MRI scan. 3-D RV endocardial surface models were reconstructed from manually delineated contours and correspondence between end-diastole (ED) and end systole (ES) was determined. Regional curvedness (C) and surface area at ED and ES were calculated as well as the area strain. The RV shape and deformation in rTOF patients differed from normal subjects in several respects. Firstly, the curvedness at ED (mean for 13 segments, 0.030 Ϯ 0.0076 vs. 0.029 Ϯ 0.0065 mm Ϫ1 ; P Ͻ 0.05) and ES (mean for 13 segments, 0.040 Ϯ 0.012 vs. 0.034 Ϯ 0.0072 mm Ϫ1 ; P Ͻ 0.001) was decreased by chronic pulmonary regurgitation. Secondly, the surface area increased significantly at ED (mean for 13 segments, 982 Ϯ 192 vs. 1,397 Ϯ 387 mm 2 ; P Ͻ 0.001) and ES (mean for 13 segments, 576 Ϯ 130 vs. 1,012 Ϯ 302 mm 2 ; P Ͻ 0.001). In particular, rTOF patients had significantly larger surface area than that in normal subjects in the free wall but not for the septal wall. Thirdly, area strain was significantly decreased (mean for 13 segments, 56 Ϯ 6 vs. 34 Ϯ 7%; P Ͻ 0.0001) in rTOF patients. Fourthly, there were increases in surface area at ED (5,726 Ϯ 969 vs. 6,605 Ϯ 1,122 mm 2 ; P Ͻ 0.05) and ES (4,280 Ϯ 758 vs. 5,569 Ϯ 1,112 mm 2 ; P Ͻ 0.01) and decrease in area strain (29 Ϯ 8 vs. 18 Ϯ 8%; P Ͻ 0.001) for RV outflow tract. These findings suggest significant geometric and strain differences between rTOF and normal subjects that may help guide therapeutic treatment. magnetic resonance imaging; curvature; right ventricular remodeling; deformation; three-dimensional reconstruction TETRALOGY OF FALLOT (TOF) is the most common cyanotic congenital heart disease (19). The main features include ventricular septum defect, subpulmonary stenosis, and overriding aorta and right ventricular (RV) hypertrophy. Surgical repair is usually performed in early infancy to widen the passage from the RV to the pulmonary artery and close the ventricular septal defect. This ensures separation of oxygen-rich and oxygenpoor blood flows to the proper chambers. Surgical repair of TOF often involves disruption of pulmonary valve integrity that leads to pulmonary regurgitation (PR; Refs. 8, 37). This in turn causes RV dilation (9, 23) and RV outflow tract (RVOT) aneurysm (2-3, 13, 28 -29). The RV dilation is usually tolerated with little or no symptoms during the first two to three decades of age. If left untreated, however, continued...

show abstract

Comparison of left ventricular ejection fraction by magnetic resonance imaging and radionuclide ventriculography in idiopathic dilated cardiomyopathy

Cited by 49 publications

References 22 publications

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major

A curvature-based approach for left ventricular shape analysis from cardiac magnetic resonance imaging

Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot

Contact Info

Product

Resources

About