Comparison of Length of Hospital Stay for Patients with Known or Suspected Methicillin‐ResistantStaphylococcusSpecies Infections Treated with Linezolid or Vancomycin: A Randomized, Multicenter Trial

Abstract

Our results support linezolid's ability to reduce medical resource use.

Linezolid: The First Oxazolidinone Antimicrobial

“…The fact that linezolid is 100% bioavailable when given orally makes dosing convenient and should lead to shorter hospital stays in patients requiring therapy for infection with resistant gram-positive organisms. Indeed, a recent study suggests that linezolid use reduces length of hospital stay in patients with known or suspected methicillin-resistant staphylococcal infections compared with vancomycin (45). These observations should be balanced against the cost of linezolid; it is relatively expensive, especially for outpatient use ($53.00 for one 600-mg tablet or 30 mL of oral suspension and $72.00 for one 600-mg intravenous vial) (46).…”

Structures of Cycloserine and 2-Oxazolidinone Probed by X-ray Photoelectron Spectroscopy: Theory and Experiment

“…The carbon atoms in the CS conformers present a different picture as the carbon atoms may be either positively charged, e.g., the carbonyl carbon C (3) with 0.642 e (CS-I), 0.663 e (CS-II) and 0.657 e (CS-III), or negatively charged, e.g., C (4) and C (5) , depending on the NBO charges of their neighboring atoms. The carbonyl carbon C (3) is positively charged in all CS conformers as it directly bonds with two negatively charged atoms, i.e., O (6) and N (2).…”

“…The carbonyl carbon C (3) is positively charged in all CS conformers as it directly bonds with two negatively charged atoms, i.e., O (6) and N (2). However, C (4) and C (5) only directly bond with one negatively charged atom, either N (7) or O (1). As a result, the NBO charges suggest that the C 1s spectrum of CS can consist of two peaks: one due to C (3) , and the other a broader peak due to C (5) and C (4) .…”

“…However, C (4) and C (5) only directly bond with one negatively charged atom, either N (7) or O (1). As a result, the NBO charges suggest that the C 1s spectrum of CS can consist of two peaks: one due to C (3) , and the other a broader peak due to C (5) and C (4) .…”

“…The other compound examined here, OX2, is also a heterocycle and its derivatives are used as drugs for treatment of MRSA (Methicillin-Resistant Staphylococcus Aureus), one of the greatest problems in modern hospitals. [3][4][5] Other drugs are under development, based on this core chemical group. 6,7 The present work also builds on our recent study of some other drug-related, heterocyclic compounds, including cyclopeptides, thiazolidine carboxylic acids and 2-azetidinone.…”