Comparison of leukocyte count and function in smoking and nonsmoking young men

Noble, Robert C.; Penny, B B

doi:10.1128/iai.12.3.550-555.1975

Cited by 109 publications

(42 citation statements)

References 21 publications

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“…These defects in neutrohil function may aiso slow local wound healing. Unhke oral neutrophils, the circulating neutrophils from smokers have been shown to have normal phagocytosis and oniy transient changes in chemotaxis (Noble & Penny 1975, Kraal & Kennedy 1979, Antibody production in periodonlal disease appears to be protective and important in localizing destruction (Ranney et al 1982), Diminished immunog!obu!in production cu!d resu!t in enhanced periodonta! destruction by microbial factors.…”

Section: Discussionmentioning

confidence: 99%

The effect of smoking on the response to periodontal therapy

Johnson

Kaldahl

et al. 1994

J Clinic Periodontology

272

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This study evaluated the effect of smoking on the clinical response to non-surgical and surgical periodontal therapy. 74 adult subjects with moderate to advanced periodontitis were treated according to a split-mouth design involving the following treatment modalities: coronal scaling, root planing, modified Widman surgery, and flap with osseous resectional surgery. Clinical parameters assessed included probing depth, probing attachment level, horizontal attachment level in furcation sites, recession, presence of supragingival plaque and bleeding on probing. Data were collected: initially, 4 weeks following phase-I therapy, 10 weeks following phase-II therapy and on a yearly basis during 6 years of maintenance care. Data analysis demonstrated that smokers exhibited significantly less reduction of probing depth and less gain of probing attachment level when compared to non-smokers immediately following active therapy and during each of the 6 years of maintenance (p < 0.05). A greater loss of horizontal attachment level was evident in smokers at each yearly exam during maintenance therapy (p < 0.05). There were no differences between groups in recession changes. In general, these findings were true for the outcomes following all 4 modalities of therapy and were most pronounced in the deepest probing depth category (> or = 7 mm). Statistical analysis showed a tendency for smokers to have slightly more supragingival plaque and bleeding on probing. In summary, smokers responded less favorably than non-smokers to periodontal therapy which included 3-month maintenance follow-up.

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Section: Discussionmentioning

confidence: 99%

The effect of smoking on the response to periodontal therapy

Johnson

Kaldahl

et al. 1994

J Clinic Periodontology

272

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“…Regarding the immune system response, smoking may have an adverse effect on fibroblast function, interfere with chemotaxis and phagocytosis in neutrophils, and negatively influence immunoglobulin production by lymphocytes. [6][7][8][9][10][11][12] Further, blood supply is reduced and platelet aggregation enhanced. The result is that smokers (S) are at greater risk of infection following surgery, and may heal more slowly.…”

Section: Local Routementioning

confidence: 99%

Tobacco as a Risk Factor for Survival of Dental Implants

Sánchez-Pérez

Moya-Villaescusa

Caffesse

2007

Journal of Periodontology

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“…Cigarette smoke causes impairment of some functions concerning both pulmonary macrophages (Green and Carolin, 1967;Harris et af. 1970;Warr and Martin, 1974) and peripheral neutrophils (Noble and Penny, 1975;Bridges er af, 1977;Corberond et al, 1979, Bridges, 1985.…”

Section: Discussionmentioning

confidence: 99%

“…Polymorphonuclear leukocytes (PMN) from peripheral blood of smokers exhibit depressed chemotaxis, when compared to the same subjects abstaining from cigarettes or to non-smokers (Noble and Penny, 1975). In addition, the chemotaxis of peripheral PMN from healthy volunteers is also inhibited by exposure in vitro to whole tobacco smoke, gas phase and water soluble fraction of smoke (Bridges et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

Protection of erdosteine on smoke‐induced peripheral neutrophil dysfunction both in healthy and in bronchitic smokers

Ciaccia

Papi

Tschirky³

et al. 1992

Fundamemntal Clinical Pharma

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The purpose of the present study was to determine whether erdosteine and its metabolites (substances containing thiol groups) can prevent the alteration of the chemotactic function of polymorphonuclear cells (PMN) from peripheral blood induced by cigarette smoke of eight healthy non-smoking volunteers, when incubated in vitro before smoke exposure, and whether oral treatment with erdosteine (900 mg/day) for two weeks might restore the chemotaxis of PMN, either from eight healthy or from 16 chronic bronchitic smokers. The chemotactic stimuli in vitro were casein, lipopolysaccharides (LPS), and formyl-methionyl-leucyl-phenyalanine (FMLP). The results of the study in vitro have confirmed that PMN from non-smoking volunteers shows a reduced chemotactic responsiveness when exposed in vitro to smoke. This can be partially prevented in a dose-related manner by pre-incubation with erdosteine, its metabolites, cysteine, and glutathione (metabolites I and II being at least 10 times more active than the intact substance and the known biological standards also containing thiol groups). The experiment on PMN from healthy smokers (in a double-blind crossover design versus placebo) has indicated that the chemotaxis can be improved only after treatment with erdosteine. The same observation has been made in the experiment on PMN from smokers affected by chronic bronchitis (in a double-blind design versus placebo with two distinct groups). In these patients the phagocytic and bactericidal activities of PMN were not affected by the smoke and therefore, neither one was influenced by erdosteine treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

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Comparison of leukocyte count and function in smoking and nonsmoking young men

Cited by 109 publications

References 21 publications

The effect of smoking on the response to periodontal therapy

The effect of smoking on the response to periodontal therapy

Tobacco as a Risk Factor for Survival of Dental Implants

Protection of erdosteine on smoke‐induced peripheral neutrophil dysfunction both in healthy and in bronchitic smokers

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