Comparison of liver enzymes level and sonographic findings value with liver biopsy findings in nonalcoholic fatty liver disease patients

Abstract

Background:This study aimed to examine the relationship between sonographic diagnosis of fatty liver and liver enzyme level with histopathologic abnormalities and liver biopsy findings in patient with the nonalcoholic fatty liver disease (NAFLD).Materials and Methods:This cross-sectional study conducted on 109 patients with diagnosed and under treatment NAFLD refer to Gastroenterology Clinics of AL Zahra Hospital in Isfahan, Iran. Age, sex, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) level recorded for all patients. Liver ultrasonography was performed for all patients. Steatosis grading and fibrosis stage were evaluated by liver biopsy.Results:We enrolled 109 subjects with NAFLD who had an indication for liver biopsy and met inclusion criteria of our study. Of these, 78 subjects (71.6%) were male and 31 subjects (28.4) were female. Mean age was 40.17 ± 11.01 years old. Our results showed there was a statistically significant relationship between ultrasonographic findings and histologic findings based on biopsy. There was statistically significant relationship between liver enzyme (ALT, AST and ALP) level and ultrasonographic findings, but there was no significant relationship between AST and ALT level and histologic findings, but the relationship between ALP level and histologic findings (steatosis and fibrosis) was statistically significant (P = 0.01).Conclusion:Ultrasonographic finding may be can use to identify nonalcoholic steatohepatitis and stage of fibrosis in patients with NAFLD, but AST and ALT level is not reliable screening test to identify stage of fibrosis and steatosis in these patients. Therefore, liver biopsy remains the gold standard for establishing steatohepatitis and advanced fibrosis in patients with NAFLD.

Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study

“…The serum ALT is known to rise with the degree of hepatic steatosis among nonpregnant population [37]. Further, the serum ALT level during the third trimester of pregnancy is known to be lower than the nonpregnant women[38].…”

Low‐molecular weight oligosaccharides from gum tragacanth (Astragalus gossypinus) ameliorate nonalcoholic fatty liver disease (NAFLD) in Wistar male rats

“…Interestingly, the rats fed on GT oligosaccharides(HFD + O100, HFD + O200) increased plasma HDL concentration and it seems that the GT oligosaccharides regulate HDL concentration by lipid catabolism, as HDL can transport cholesterol from peripheral tissues to the liver for oxidation (Muanprasat & Chatsudthipong, 2017;Tao et al, 2019). In accordance with decreased total triglycerides, cholesterol, and re- HOSSEIN ZADEH et al Khodadoostan et al, 2016;Taliercio et al, 2013). Our finding showed that the using of GT oligosaccharides lower HFD induced high plasma concentration of ALT and AST, indicating that administration of GT oligosaccharides protect our rats against HFD induced liver damage.…”

“…Moreover, our findings indicated that the rats fed HFD showed significantly higher plasma concentration of ALT and AST compared to the control and GT oligosaccharides groups. ALT and AST are known an important biomarkers related to hepatocytes function, and the increased plasma concentration of aforementioned enzymes implied occurrence of Cholestasis, imbalance of lipid and carbohydrate metabolism, hepatotoxicity and hepatocytes injury, which are associated with NAFLD and hyperlipidemia (Chang et al, 2013; Khodadoostan et al, 2016; Taliercio et al, 2013). Our finding showed that the using of GT oligosaccharides lower HFD induced high plasma concentration of ALT and AST, indicating that administration of GT oligosaccharides protect our rats against HFD induced liver damage.…”

Ameliorating Effects of Bioactive Peptides Extracted from Litopenaeus vannamei Wastes on Oxidative Stress, Glucose Regulation, and Autophagy Gene Expression in Nonalcoholic Fatty Liver-Induced Rats

“…As a result of liver cell damage, the concentration of liver enzymes (ALT, AST), amylase, and ALP increase in plasma [ 42 ]. ALP is a membrane hydrolysis enzyme that is used as a biomarker for cholestasis, which is caused by hepatic steatosis and a lipid-carbohydrate metabolic imbalance [ 46 , 47 ]. An increase above parameters stimulates proinflammatory cytokines (TNF-ɑ and IL-6) in the bloodstream, resulting in reduced lipid degradation and increase accumulation [ 48 ].…”