Comparison of local intravascular drug-delivery catheter systems

Gonschior, P.; Pahl, Clemens; Huehns, Tanya Y.; Gerheuser, Florian; Erdemci, A.; Larisch, Katharina; Dellian, Marc; Deil, Stefan; Goetz, A.; Lehr, Hans A.; ̈fling, Berthold Ho

doi:10.1016/0002-8703(95)90139-6

Cited by 32 publications

(23 citation statements)

References 16 publications

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“…[20][21][22] Perivascular tissue appears to act as a depot, and adventially delivered substances can be observed in all arterial layers, including inner layers, for up to 21 days with the needle injection catheter. 23 Similarly, our studies demonstrated the presence of delivered gene and its mRNA within the arterial wall up to 21 days after delivery. The dosage of 30 g DNA was less than a tenth of that used in comparable experiments where the local drug delivery devices were modified balloon catheters.…”

Section: Figure 3 Proliferation Assays Of Smooth Muscle Cells After Tsupporting

confidence: 70%

“…21 Adventitial delivery is a novel form of delivery with the potential for creating a local depot of active agent. [22][23][24] In this article, the effect of locally delivering the gene for the immature form of cecropin A, one member of this family of peptides, pre-pro-cecropin A, into and around injured arteries using a novel needle injection catheter was investigated.…”

Section: Introductionmentioning

confidence: 99%

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Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation

et al. 1999

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Section: Figure 3 Proliferation Assays Of Smooth Muscle Cells After Tsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation

et al. 1999

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“…Recently, several devices with modified needles capable of direct injection into interstitial tissue of either myocardium or vasculature have been described. Delivery of agents and genes directly into the adventitia, bypassing the delivery barriers represented by the intima and media, 110 may provide for relatively rapid and efficient delivery compared with endovascular approaches. 111 The feasibility of adventitial transduction by direct deposition of adenovirus on the abluminal aspect of the vessel using surgical approaches has been reported, 112 and recent experiments have demonstrated adenoviral transduction of the adventitia and perivascular tissue by transvascular needle injection using a delivery protocol requiring only several seconds.…”

Section: Perivascular Delivery Approaches: Transvascular and Pericardialmentioning

confidence: 99%

Gene Therapy for Restenosis

Baek

March

1998

Circulation Research

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—Intensive work over the past decade has been directed to the study of vascular gene transfer as an approach to the unresolved problem of restenosis. This effort has resulted in a significant foundation of knowledge relative to the activities of potentially therapeutic gene products as well as the capabilities and limitations of vector systems and mechanical delivery modalities available for effecting the vascular expression of these gene products. In several instances, significant progress has been made by experiments highlighting unexpected difficulties and the need for more comprehensive understanding. It is thus now possible to clearly define and address specific challenges that must be overcome in order to make feasible progress from the preclinical to the clinical arena. The key challenges at present appear to include the evolution of clinically practical delivery methods that meet the kinetic requirements of achieving efficient gene transduction and the availability of vectors that maximize efficiency while minimizing undesirable host responses. Emerging data suggest that approaches to solving each of these issues may have recently been developed. Basic research evaluating these new delivery mechanisms and molecular vectors is essential to establish their true potential for use in the clinical arena.

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“…In recent years, dispatch catheters 22 and new needle injection catheters 23 have been used clinically for local intracoronary drug administration. We previously reported that administration of HpD in a very small amount using a dispatch catheter allows the local accumulation of significant amounts of HpD in the arteriosclerotic intima when compared with systemic administration.…”

Section: Fluorescence Spectral Analysis Of Arteriosclerotic Lesions Umentioning

confidence: 99%

Fluorescence Spectrum Analysis of Atherosclerotic Plaque Using Doxycycline

et al. 1999

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arious interventional therapies are presently used in the treatment of ischemic heart disease. In clinical trials in the US, percutaneous transluminal laser coronary angioplasty (PTLCA) was performed on 3,000 patients and 3,592 lesions using excimer laser, with a reported success rate of 84%. 1 When this method is compared with percutaneous transluminal coronary angioplasty (PTCA) using a balloon, PTLCA can be performed on diffuse lesions in which PTCA is difficult, and it may be possible to use the laser to recanalize a chronic total occlusion, a lesion in which the passage of a guide wire would be very difficult. In addition, PTCA is contraindicated in ostial stenosis, and PTLCA is considered the first choice in closed chest treatment. In PTLCA, however, unexpected coronary perforation occurs in between 1.2 to 2.4% of cases, 1-4 a rate which is obviously higher than for PTCA. As avoidance of coronary perforation is the paramount consideration in PTLCA, the requirement is for an appropriate guidance system to show the condition of the hypertrophic intima and the degree of ablation in real time, so that the atheroma alone is selectively ablated and the tunica media not irradiated.At present, evaluation of coronary arteriosclerotic lesions is made using angioscopy and intravascular ultrasound, neither of which can be inserted into the coronary artery at the same time as the laser irradiation system and so cannot be the appropriate guidance system. Fluorescence spectrum analysis is a method by which the fluorescence induced by irradiation at specific wavelengths of an arteriosclerotic lesion is examined in detail to make the diagno-

show abstract

Comparison of local intravascular drug-delivery catheter systems

Cited by 32 publications

References 16 publications

Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation

Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation

Gene Therapy for Restenosis

Fluorescence Spectrum Analysis of Atherosclerotic Plaque Using Doxycycline

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