Comparison of Lorazepam and Zopiclone for Insomnia in Patients with Stroke and Brain Injury

Shan, Rodney S. Li Pi; Ashworth, Nigel

doi:10.1097/00002060-200406000-00003

Cited by 43 publications

(16 citation statements)

References 25 publications

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“…Treatment options include sedative antidepressants such as mianserin 1 and mirtazapine, hypnotics and anxiolytics such as zopiclone and lorazepam, 27 acupuncture, 28 improving sleep hygiene, and cognitive behavioral techniques. 29 Cognitive therapy may also be useful in treating SI 29 and poststroke depression.…”

Section: Discussionmentioning

confidence: 99%

Is Insomnia Associated With Suicidality in Stroke?

Tang

Liang

et al. 2011

Archives of Physical Medicine and Rehabilitation

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Section: Discussionmentioning

confidence: 99%

Is Insomnia Associated With Suicidality in Stroke?

Tang

Liang

et al. 2011

Archives of Physical Medicine and Rehabilitation

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“…Li Pi Shan and Ashworth examined zopiclone (nonbenzodiazepinebenzodiazepine receptor agonist) and lorazepam (traditional benzodiazepine) and found them to be equally effective in treating insomnia in TBI [33]. Kemp et al found that neither melatonin (sleep-promoting hormone) nor amitriptyline (tricyclic antidepressant) was successful in treating insomnia in TBI [34].…”

Section: Pharmacological Treatmentmentioning

confidence: 99%

Insomnia in the context of traumatic brain injury

Zeitzer

Friedman²,

O’Hara³

2009

JRRD

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Abstract-Traumatic brain injury (TBI) is one of the leading causes of morbidity and mortality in the United States. One of the most common comorbidities of TBI is the disruption of normal sleep. While often viewed as a nuisance symptom, sleep disruption can delay TBI recovery and negatively affect many of the psychological (e.g., anxiety, depression) and neuromuscular (e.g., pain) sequelae of TBI, decreasing quality of life. Treatment of sleep disruption in the context of TBI is complicated by issues of an altered neuronal milieu, polypharmacy, and the complex relationship between the various comorbidities often found in patients with TBI. Given the growing number of veterans returning from combat with TBI and the elevated risk of comorbid disrupted sleep, both caused by and independent of TBI, a comprehensive review of sleep disruption and its treatment is of great relevance to the Department of Veterans Affairs.

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“…There were no major differences in sleep characteristics or cognitive performance on the Mini Mental Status Exam. 58 In addition, many sedating antidepressants are used for insomnia, especially when comorbid depression exists. These medications include trazodone, mirtazapine, and doxepin.…”

Section: Treatmentmentioning

confidence: 99%

Traumatic brain injury-induced sleep disorders

Viola-Saltzman¹,

Musleh²

2016

NDT

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Sleep disturbances are frequently identified following traumatic brain injury, affecting 30%–70% of persons, and often occur after mild head injury. Insomnia, fatigue, and sleepiness are the most frequent sleep complaints after traumatic brain injury. Sleep apnea, narcolepsy, periodic limb movement disorder, and parasomnias may also occur after a head injury. In addition, depression, anxiety, and pain are common brain injury comorbidities with significant influence on sleep quality. Two types of traumatic brain injury that may negatively impact sleep are acceleration/deceleration injuries causing generalized brain damage and contact injuries causing focal brain damage. Polysomnography, multiple sleep latency testing, and/or actigraphy may be utilized to diagnose sleep disorders after a head injury. Depending on the disorder, treatment may include the use of medications, positive airway pressure, and/or behavioral modifications. Unfortunately, the treatment of sleep disorders associated with traumatic brain injury may not improve neuropsychological function or sleepiness.

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Comparison of Lorazepam and Zopiclone for Insomnia in Patients with Stroke and Brain Injury

Abstract: Zopiclone is equally effective as lorazepam in the treatment of insomnia in stroke and brain-injured patients.

Cited by 43 publications

References 25 publications

Is Insomnia Associated With Suicidality in Stroke?

Is Insomnia Associated With Suicidality in Stroke?

Insomnia in the context of traumatic brain injury

Traumatic brain injury-induced sleep disorders

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