Comparison of Low and High Dose of Vitamin D Treatment in Nutritional Vitamin D Deficiency Rickets

Cesur, Yaşar; Çaksen, Hüseyîn; Gündem, Alpaslan; Kırımi, Ercan; Odabaş, Dursun

doi:10.1515/jpem.2003.16.8.1105

Cited by 106 publications

(97 citation statements)

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“…Serum calcium, phosphorus, alkaline phosphatase, magnesium, serum 25-hydroxycholecalciferol, plasma intact parathormone levels and urinary Ca/creatine ratio were determined; they did not find any difference between the doses in the improvement of rickets. However, hypercalcemia was present in infants who had been administered 300,000 IU and 600,000 IU of vitamin D [20].…”

Section: Resultsmentioning

confidence: 98%

The efficacy of oral versus parentral vitamin D in treatment of nutritional rickets

Rabea¹,

Abdelrahim²,

Meabed³

2012

Med-Science

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Section: Resultsmentioning

confidence: 98%

The efficacy of oral versus parentral vitamin D in treatment of nutritional rickets

Rabea¹,

Abdelrahim²,

Meabed³

2012

Med-Science

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“…17 Cesur Y et al showed that 150,000 IU or 300,000 IU of vitamin D was adequate in the treatment of vitamin D deficiency, but 600,000 IU of vitamin D may carry the risk of hypercalcemia. 18 Gordon CM et al demonstrated that giving high dose vitamin D supplementation is essential to increase vitamin D level in children. This is probably due to higher compliance for single dose when compared to daily dose.…”

Section: Discussionmentioning

confidence: 99%

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

Mugunthan

Rao

Midha

et al. 2017

Int J Contemp Pediatr

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Background: Vitamin D deficiency remains the most common cause of rickets globally and is highly prevalent in developing countries including India. This study aimed to compare the efficacy of vitamin D and calcium together with calcium alone on growth parameters of children with vitamin D deficiency in community based setting.Methods: A randomized controlled trial was conducted in community based setting in Kanpur district. Multistage random sampling technique was used to select a total of 395 children between 2 years to 5 years from 5 villages of block Vidhunu. Of these, 138 children were randomized into two groups using balanced block randomization technique. Group 1 received vitamin D with calcium together and group 2 received calcium alone for a period of 12 months. Anthropometry, serum vitamin D, calcium, alkaline phosphatase levels were estimated at baseline and after 12 months. Data was analyzed using SPSS 20. Student’s t test was used to analyze the differences in growth and laboratory parameters in the two groups. Multiple linear regression analysis was used to assess the effect of various factors on the growth parameters.Results: Prevalence of vitamin D deficiency was 78.7%. Baseline characteristics of both groups were similar. After 12 months, group 1 demonstrated significantly greater improvement in weight SD score (21.4%) and height SD score (10.3%) and growth velocity (9.1 cm/year) compared to group 2 (14.3%, 7.8% and 6.9 cm/ year respectively). Also subjects in group 1 showed significantly greater improvement in serum levels of vitamin D, calcium and alkaline phosphatase than group 2.Conclusions: Vitamin D supplementation along with calcium improves the growth of children. Regular supplementation of all children with vitamin D can be considered as a policy for prevention of malnutrition.

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“…To this end, inactive vitamin D (cholecalciferol or ergocalciferol) is used in treatment. Generally two treatment methods are preferred [14,15,18,19]. …”

Section: Treatment and Preventionmentioning

confidence: 99%

“…Administration of 600.000 units of vitamin D has been shown to cause hypercalcemia in cases of infantile rachitism. It has been reported in many studies that 150-300.000 units of vitamin D is an effective and safe method of treatment [19]. A recent study also demonstrated that a single dosage of 300.000 units of vitamin D IM is effective in cases of malnutrition rickets [20].…”

Section: Stoss Therapymentioning

confidence: 99%

“…This treatment evokes a rapid clinical response, resulting in biochemical recovery in a few days and radiological recovery in 10-15 days. There are different opinions, and it is recommended by some authors to employ calcium therapy for 1-2 weeks to provide elementary Ca in both therapies even when hypocalcemia findings are not present [18,19].…”

Section: Stoss Therapymentioning

confidence: 99%

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Nutritional Rickets in Turkey

Özkan

2010

EAJM

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Nutritional rickets (NR) remains the most common form of developmental bone disease, in spite of the eff orts of clinicians and health care providers to reduce the incidence of the disease in Turkey. Today, it is well known that the etiology of NR exists along a spectrum ranging from isolated vitamin D deficiency to isolated calcium defi ciency. In Turkey, almost all NR results from vitamin D defi ciency that may have temporary but profound eff ects on short-and long-term skeletal development. Recent evidence suggests that vitamin D defi ciency during infancy may predispose a patient to diseases such as diabetes mellitus, cancer, multiple sclerosis, etc. The factors responsible for the high prevalence of vitamin D defi ciency in developing countries and its resurgence in developed countries include the following: limited sunshine exposure as individuals spend more time indoors watching television and working on computers or intentional sunshine avoidance for skin cancer prevention. Traditional clothing (covered dress) further limits the exposure to sunshine and thus decreases the endogenous synthesis of vitamin D. In Turkey, maternal vitamin D defi ciency and breast feeding without supplementation are the most prominent reasons. The diagnosis of NR is established with a thorough history and physical examination and confi rmed by laboratory evaluation. In conclusion, recent literature has drawn attention to the supplemental doses of vitamin D required to achieve a serum 25-hydroxyvitamin D level of at least 20 ng/ ml (50 nmol/l), the serum concentration that is needed to optimize absorption of dietary calcium, suppress excess secretion of parathyroid hormone, and reduce fracture risk as well as prevent long-term negative eff ects. Key Words: Nutritional rickets, Turkey ÖzetNutrisyonel rikets, ülkemizdeki sıklığını azaltmaya yönelik tüm çabalara rağ-men, hala en sık karşılaşılan büyüyen kemik doku hastalığıdır. NR, günümüzde izole vitamin D eksikliği şeklinde karşımıza çıkabileceği gibi sadece kalsiyum eksikliğine bağlı olarak ta karşımıza çıkabilmektedir. Ülkemizde tanı konulan vakaların çoğunu vitamin D eksikliği olan vakalar oluşturmaktadır ve uzun vadede iskelet sistemi üzerinde kalıcı deformatif etkiler yapabilmektedir. Son çalışmalarda, erken bebeklik dönemindeki vitamin D eksikliğinin yaşamın ileri dönemlerinde ortaya çıkan diabet, kanser ve multipl skleroz gibi hastalıkları predispoze ettiği bildirilmektedir. Gelişmiş ve gelişmekte olan ülkelerde vitamin D eksikliğinin en sık nedenleri olarak; evde bilgisayar ve televizyon başın-da zaman geçirmek ve dolayısı ile güneş ışığından mahrum kalmak veya hava kirliliği veya kanser korkusu nedeni ile doğrudan güneş ışığından uzak durmak belirtilmektedir. Diğer yandan geleneksel örtülü giyim de güneş ışığının deri dokusuna ulaşımı engelleyerek endojen vitamin D sentezini azaltmaktadır. Türkiye'de ise maternal vitamin D eksikliği ve vitamin D desteği yapılma-dan sadece anne sütü ile beslenen bebekler vitamin D eksikliği bakımından en riskli grubu oluşturmakta...

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Comparison of Low and High Dose of Vitamin D Treatment in Nutritional Vitamin D Deficiency Rickets

Cited by 106 publications

References 1 publication

The efficacy of oral versus parentral vitamin D in treatment of nutritional rickets

The efficacy of oral versus parentral vitamin D in treatment of nutritional rickets

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

Nutritional Rickets in Turkey

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