Comparison of Low Dietary Calcium and Sodium Sulfate for the Potentiation of Tetracycline Antibiotics in Broiler Diets

Waldroup, P. W.; Owen, James; Blackman, J. R.; Short, J. R.; Ramsey, B. E.; Slagter, P. J.; Johnson, Z. B.

doi:10.2307/1590060

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Ion concentrations are higher in feed than in water, therefore, the absorption of OTC from the GIT is likely more inhibited when administrated with feed than with water. This was also observed by other researchers (Price et al 1959, Waldroup et al 1981, Wanner et al 1991.…”

Section: Discussionsupporting

confidence: 88%

Polish Journal of Veterinary Sciences

Ziółkowski

Madej-Śmiechowska

Grabowski

et al. 2019

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The aim of this study was to determine to what extent the ions present in hard water (125 mg/L of MgCl 2 and 500 mg/L of CaCl 2 ) may intensify the feed-induced decrease in oxytetracycline (OTC) absorption rate in broiler chickens after single oral administration at a dose of 15 mg/kg. Drug concentrations in plasma were determined by liquid chromatography-tandem mass spectrometry and combined, compartmental and non-compartmental approach was used to assess OTC pharmacokinetics.The administration of feed decreased the absolute bioavailability (F) of OTC from 12.70%±4.01 to 6.40%±1.08, and this effect was more pronounced after the combined administration of OTC with feed and hard water (5.31%±0.90). A decrease in the area under the concentration-time curve (AUC 0-t ), (from 10.18±3.24 µg•h/ml in control to 5.13 µg•h/ml±1.26 for feed and 4.26 µg•h/ml±1.10 for feed and hard water) and the maximum plasma concentration of OTC (C max ) (from 1.22±0.18 µg/ml in control, to 1.01 µg/ml ±0.10 for hard water, 0.68 µg/ml±0.10 for feed and 0.61 µg/ml±0.10 for feed and hard water) was observed.The results of this study indicate that feed strongly decreases F, AUC 0-t and C max of orally administered OTC. The ions present in hard water increase this inhibitory effect, which suggests that, therapy with OTC may require taking into account local water quality and dose modification, particularly when dealing with outbreaks caused by less sensitive microorganisms.

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Section: Discussionsupporting

confidence: 88%

Polish Journal of Veterinary Sciences

Ziółkowski

Madej-Śmiechowska

Grabowski

et al. 2019

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“…Potentiation of tetracycline in poultry feeds is commonly achieved by reducing calcium concentration in the feed to prevent chelation of tetracycline and improve drug absorption (Price, Zolli, Atkinson, Collins, & Luther, ; Sebree & Roberts, ; Waldroup et al., ). Tetracycline's are often used in poultry starter diets, therefore reducing the concentration of calcium in diets should only be used for short periods since calcium is essential for growth (Waldroup et al., ). Please refer to Table for further information on tetracycline drug residue studies.…”

Section: Antibacterialsmentioning

confidence: 99%

Drug residues in poultry meat: A literature review of commonly used veterinary antibacterials and anthelmintics used in poultry

Patel

Marmulak

Gehring

et al. 2018

Vet Pharm & Therapeutics

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Poultry meat is widely consumed throughout the world and production practices often include the administration of pharmaceutical products. When appropriate, extra-label drug use of medications is necessary, but scientifically derived drug withdrawal intervals must be observed so that poultry meat is not contaminated with drug residues which could pose health risks to consumers. Over the past decade, there has been increased advocacy for judicious use of antimicrobial drugs for treating food animals. Judicious use of medications is commonly referred to as practices that reduce antibiotic resistance, but also includes residue avoidance. In that light, many investigators have performed scientific studies and have published estimated pharmacokinetic parameters for veterinary medications used in commercial avian species. This manuscript is a review of medication classes that have been studied in poultry (mostly chickens) with an emphasis on drug residue depletion in poultry meat.

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Antimicrobial prescribing guidelines for poultry

Gray¹,

Jenner²,

Norris³

et al. 2021

Aust Veterinary J

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Forewordantimicrobial prescribing guidelines for poultry Antimicrobials are essential to modern medicine for treating a range of infections in humans and animals. Importantly, antimicrobial resistance (AMR) is a growing global threat that presents a serious risk to human and animal health. Inappropriate and/or unrestrained use of antimicrobials in humans and animals exerts a strong selection pressure on microbial populations to evolve resistant traits. As a result, antimicrobials have become less effective over time leading to treatment complications and failures, and increased healthcare costs for people and animals. Resistant organisms spread between people, animals and the environment. Globalisation and international travel facilitates this spread between countries.Here in Australia, the veterinary profession and food-producing animal industries have a long history of addressing AMR. Their previous and ongoing worka result of partnerships across the animal sectorhas resulted in demonstrated low levels of AMR in our food-producing animals. Over the past 5 years, the veterinary profession has consolidated its partnership with industry and government by helping to successfully implement Australia's First National Antimicrobial Resistance Strategy 2015-19. With the recent release of Australia's National Antimicrobial Resistance Strategy -2020 and Beyond (2020 AMR Strategy), the veterinary profession will continue to play a critical role in how we minimise AMR.One of the seven key objectives of the 2020 AMR Strategy relates to appropriate antimicrobial usage and antimicrobial stewardship practices. Resistance to antimicrobials occurs naturally in microorganisms, but it is significantly amplified by antimicrobial overuse, growth promotion use, and poor husbandry and management.The antimicrobial prescribing guidelines for poultry directly addresses the fourth objective of the 2020 AMR Strategy, and in particular, Priority Area for Action 4.1, that seeks to 'ensure that coordinated, evidence-based antimicrobial prescribing guidelines and best-practice supports are developed and made easily available, and encourage their use by prescribers'. These guidelines for Australian poultry veterinarians are sure to be a ready resource. They have been developed specifically for the Australian poultry industry and contain best-practice prescribing information to help clinical veterinarians in their day-to-day use of antimicrobials. The guidelines encourage veterinarians to first pause and consider the need to use antimicrobials in that circumstance: Are there effective non-antimicrobial alternatives? Prevention and control of infections through strict on-farm biosecurity is a recognised approach to minimising disease entry and the need to use antimicrobials. Vaccination may also be available to control several important poultry diseases. If antimicrobial use is indicated, have you considered the five rights: right drug, right time, right dose, right duration and right route? Using a lower rating or narrow-spectrum antimicrobial i...

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Comparison of Low Dietary Calcium and Sodium Sulfate for the Potentiation of Tetracycline Antibiotics in Broiler Diets

Cited by 6 publications

References 8 publications

Polish Journal of Veterinary Sciences

Polish Journal of Veterinary Sciences

Drug residues in poultry meat: A literature review of commonly used veterinary antibacterials and anthelmintics used in poultry

Antimicrobial prescribing guidelines for poultry

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