Comparison of low dose versus ultra-low dose hormone therapy in menopausal symptoms and quality of life in perimenopause women

Song, Yang; Xu, Wenxian; Chatooah, Namratta Devi; Chen, Jianfang; Huang, Yizhou; Chen, Peiqiong; Lan, Yibing; Li, Chunming; Ying, Qian; Ma, Linjuan; Zhou, Jianhong

doi:10.1080/09513590.2019.1666815

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Reduction in the clinical symptoms after three courses of treatment, and a reduction in the modified KMI score of 20%-50% was defined as effective treatment. No reduction in the clinical symptoms after three courses of treatment, and a reduction in the modified KMI score of < 20% was defined as ineffective treatment[ 9 ]. The overall treatment effectiveness rate was calculated as the sum of the cure, significant, and effective rates.…”

Section: Methodsmentioning

confidence: 99%

Effects of hormone replacement therapy on mood and sleep quality in menopausal women

Liu,

Huang,

2024

World J Psychiatry

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BACKGROUND Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal women. However, some patients report experiencing adverse effects. AIM To analyze the effects of hormone replacement therapy in menopausal female patients. METHODS A total of 152 menopausal female patients admitted to the Gynecology Department of the Ganzhou Maternal and Child Health Hospital between January 2021 and December 2023 were divided into the observation group (n = 76, conventional treatment + hormone replacement therapy) and the control group (n = 76, conventional treatment only) via random casting. The improvement observed in the following items were compared between the groups: Kupperman menopausal index (KMI), emotional state [The Positive and Negative Affect Scale (PANAS)], sleep quality [Self-Rating Scale of Sleep (SRSS)], treatment effectiveness, and treatment safety. RESULTS The modified KMI and SRSS scores of the observation group were lower than those of the control group after three rounds of treatment. The improvement in the PANAS score observed in the observation group was greater than that observed in the control group (P < 0.05). The total treatment effectivity rate in the observation group was higher than that in the control group (86.84% vs 96.05%, χ 2 = 4.121, P = 0.042). The incidence rate of adverse reactions in the two groups was comparable (6.58% vs 9.21%, χ 2 = 0.361, P = 0.547). CONCLUSION Hormone replacement therapy effectively improved the clinical symptoms, actively channeled negative emotions, and improved the quality of sleep in menopausal patients, indicating its effectiveness and safety.

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Section: Methodsmentioning

confidence: 99%

Effects of hormone replacement therapy on mood and sleep quality in menopausal women

Liu,

Huang,

2024

World J Psychiatry

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“…В другом недавнем сравнительном исследовании [7] по применению низких и ультранизких доз МГТ для купирования климактерических симптомов и повышения качества жизни авторы показали, что ультранизкодозированная МГТ может иметь большее преимущество с точки зрения безопасности и переносимости.…”

Section: эффективность ультранизкодозированной менопаузальной гормональной терапии в отношении вазомоторных симптомовunclassified

Advantages of the Ultralow-dose Hormonal Menopausal Therapy: An Ample Opportunity with Minimal Risks

Апетов¹,

Apetova²

2021

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Objective of the Review: To analyse the efficacy and safety of the ultralow-dose menopausal hormonal therapy (MHT). Key Points. In developed countries, the life expectancy is growing and the issue of improved quality of life of elderly women is becoming quite acute. On the average, a third (or a half for early menopause) of a modern woman’s life falls on the post-menopause period. Termination of oestrogen synthesis in ovaries during menopause is associated with marked reduction in the quality of life, development of vasomotor symptoms, sleep disturbances, accelerated skin ageing, an increased risk of cardiovascular pathologies and a number of somatic disorders, urinogenital atrophy, osteoporosis, and cognitive disorders. MHT is a proven and efficient means of quality of life improvement; however, the safety of sex hormone therapy in elderly women is still a topical issue. In this article, we are discussing the efficacy and safety of oral MHT drug containing 0.5 mg of 17β-estradiol and 2.5 mg of didrogesteron. Conclusion. The advent of ultralow-dose MHT drugs allowed significantly reducing the number of side effects from sex hormone therapy during post-menopause vs. side effects from higher doses of estradiol with comparable clinical effects. Keywords: menopausal hormonal therapy, ultralow-dose drugs, estradiol, didrogesteron.

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Estradiol valerate

2021

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Comparison of low dose versus ultra-low dose hormone therapy in menopausal symptoms and quality of life in perimenopause women

Cited by 5 publications

References 27 publications

Effects of hormone replacement therapy on mood and sleep quality in menopausal women

Effects of hormone replacement therapy on mood and sleep quality in menopausal women

Advantages of the Ultralow-dose Hormonal Menopausal Therapy: An Ample Opportunity with Minimal Risks

Estradiol valerate

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