hronic congestive heart failure (CHF) is a complex metabolic syndrome resulting from global hypoperfusion and neurohumoral activation. Sympathoadrenergic hyperactivity and stimulation of the reninangiotensin -aldosterone cascade promote endothelial dysfunction in the macro-and microcirculation, and thus influence the distribution of the terminal blood flow. The increased total peripheral resistance, reduction of blood supply and impaired peripheral vascular dilatation in response to vasodilator stimuli result in atrophy of skeletal muscle and decreased oxidative activity. Physical training could reverse the pathologic changes in patients with CHF and there have been many reports during the past decade that clearly demonstrate the benefits of exercise on functional capacity, ventilation, metabolic status, autonomic control of heart rate (HR) variability and other parameCirculation Journal Vol. 70, January 2006 ters, 1-5 including skeletal muscle performance and impaired endothelial function. 6,7 However, most of the actual training protocols are based on systemic exercise requiring increased cardiac output, which cannot be achieved by all patients, and in general are only suitable for patients with a moderately advanced grade of CHF; less attention has been paid to the development of safe and efficient training programs for patients with severe grades of the disease. Background This study was designed to evaluate the effects of low-frequency electrical stimulation (LFES) on muscle strength and blood flow in patients with advanced chronic heart failure (CHF).
Methods and ResultsPatients with CHF (n=15; age 56.5±5.2 years; New York Heart Association III -IV; ejection fraction 18.7±3.3%) were examined before and after 6 weeks of LFES (10 Hz) of the quadriceps and calf muscles of both legs (1 h/day, 7 days/week). Dynamometry was performed weekly to determine maximal muscle strength (Fmax; N) and isokinetic peak torque (PTmax; Nm); blood flow velocity (BFV) was measured at baseline and after 6 weeks of LFES using pulsed-wave Doppler velocimetry of the right femoral artery.