Comparison of Lyophilized Glutaraldehyde-Preserved Bovine Pericardium with Different Vascular Prostheses for Use as Vocal Cords Implants: Experimental Study

Abstract

This study compared the use of lyophilized glutaraldehyde-preserved bovine pericardium (LGPBP), polytetrafluoroethylene (PTFE), polyethylene terephthalate (PET), and Teflon felt (TF) as implants for vocal cords (VC) medialization and aimed to assess the endoscopic, macroscopic, and microscopic VC changes after medialization in a canine model. In 18 mongrel dogs, the right VC were medialized with LGPBP and the left were implanted as follows: Group I (n = 6): LGPBP and PTFE; Group II (n = 6): LGPBP and PET; Group III (n = 6): LGPBP and TF. Surgical handling of the implants was compared. Three months after surgery, macroscopic and microscopic changes of VC and implants were evaluated. LGPBP offered the best surgical handling (p = 0.005, Kruskal-Wallis). TF implants showed extrusion (p = 0.005, Kruskal-Wallis) and severe inflammation. All VC formed fibrous capsules around the implants; the ones developed by LGPBP implants were thinner (p = 0.001, ANOVA, Tukey). VC implanted with synthetic materials showed eosinophilic infiltration (p = 0.01, Kruskal-Wallis). We concluded that the LGPBP could be used as an implant for VC medialization because it is biocompatible, easy to handle and remove during surgical procedures, and nonabsorbable or extrudable and produces an inflammatory reaction similar to PTFE and PET.

The life‐cycle and restoration of the human vocal fold

“… 70 For this approach to be successful, the implant must influence the inflammatory/immune response away from the native injury response that involves the deposition of fibrous tissue. There are several reports of success in this using hyaluronic acid hydrogel, 71 , 72 collagen hydrogel, 73 gelatin hydrogel with basic fibroblast growth factor (bFGF), 74 decellulaized bovine vocal fold, 75 and decellularized porcine small intestine submucosa. 76 However, translation of these approaches into human subjects is yet to occur, and in most cases and the molecular pathway by which the material and/or biofactors switch the native reparative fibrotic response to a restorative regenerative response is poorly described.…”

Designing and 3d Printed Pla Based Implant Used in Treatment for Unilateral Vocal Cord Paralysis

“…Hydroxyapatite (HA) [23], [26] Rapid determination of correct size and position, Calcium hydroxyapatite is a FDA approved material,…”