Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease

Crook, David; Knuesel, Patrick R.; Froehlich, Johannes M.; Eigenmann, Franz; Unterweger, M; Beer, Jürg H.; Ra, Kubik-Huch

doi:10.1097/meg.0b013e32830ce7a7

Cited by 44 publications

(21 citation statements)

References 20 publications

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“…CE does appear to be superior to MRE for the evaluation of GI bleeding (mainly in non-IBD patients) 39 and superior for the detection of mucosal lesions in small studies specific to patients with CD. 40,41 The prospective studies comparing CE with both CTE and MRE are summarized in Table 2.…”

Section: Comparisons With Ct/mrementioning

confidence: 99%

Capsule endoscopy for small-bowel evaluation in Crohn's disease

Doherty

Moss

Cheifetz

2011

Gastrointestinal Endoscopy

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Section: Comparisons With Ct/mrementioning

confidence: 99%

Capsule endoscopy for small-bowel evaluation in Crohn's disease

Doherty

Moss

Cheifetz

2011

Gastrointestinal Endoscopy

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“…Furthermore, capsule endoscopy had a 71% diagnostic yield for active Crohn’s disease, compared with 39% for CT enterography/enteroclysis (p < 0.0001). Four trials compared capsule endoscopy with MR enterography in patients with established Crohn’s disease [11,12,13,14]. Diagnostic yields for capsule endoscopy and MR enterography were 70 and 79% (p = 0.65), respectively, but it is not clear how this correlated with either symptoms or the outcome of therapeutic intervention.…”

Section: Established Crohn’s Diseasementioning

confidence: 99%

Capsule Endoscopy and Crohn’s Disease

Hartmann

2011

Dig Dis

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Capsule endoscopy has been shown to detect small bowel inflammatory changes better than any other imaging modality. Selection criteria have been optimized to increase the yield of capsule endoscopy in patients suspected of having Crohn’s disease. Capsule endoscopy allows for earlier diagnosis of Crohn’s disease of the small bowel and improved diagnosis of colitis in patients where it is unclear if they suffer from Crohn’s or ulcerative colitis. A test capsule is available to assess for small bowel strictures and thus avoid capsule retention. It is envisioned that the manner in which we treat Crohn’s disease in the future will change, based on earlier diagnosis and treatment aimed at mucosal healing rather than symptom improvement.

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“…Several meta-analyses 9 10 23 24 showed that CE has superior diagnostic yields to SB barium studies, ileocolonoscopy, push enteroscopy and CTE in both suspected and established SB CD. CE appears to be better than MRE at identifying SB mucosal lesions, while MRE is more accurate at diagnosing mural, peri-mural and extra-enteric manifestations 25 26. …”

Section: Discussionmentioning

confidence: 89%

Development of a predictive model of Crohn’s disease proximal small bowel involvement in capsule endoscopy evaluation

et al. 2016

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Background and study aims: One of the indications for capsule endoscopy (CE) is the detection of proximal small bowel (SB) involvement in Crohn's disease (CD) patients. Our aim was to assess clinical, laboratory and endoscopic predictors associated with proximal SB involvement in CD patients submitted to CE. Patients and methods: Retrospective multicenter study in which Lewis score (LS) was systematically determined in 190 CE of patients diagnosed with CD between 2003 and 2014. Results: Significant inflammatory activity (LS > 135) was present in 23 % of the patients in the first tertile and in 31 % of the patients in the second tertile. Albumin, haemoglobin, and total proteins were significantly lower in patients with a LS > 790 compared to patients with a LS < 135, while white blood cell counts and C-reactive protein were significantly higher. In the univariable analysis, a higher risk for proximal SB involvement at CE was associated with ileal involvement at ileocolonoscopy (OR 2.858, P = 0.006), higher platelets levels (OR 1.005, P = 0.004) and significant weight loss (OR 2.450, P = 0.006). In logistic regression, ileal involvement at ileocolonoscopy (OR 6.817, P = 0.003), stricturing behavior (OR 8.653, P = 0.011) and significant weight loss (OR 3.629, P = 0.028) were independently associated with proximal SB involvement at CE. Considering the ROC curve of this model, a cut-off > 0.249 predicts proximal SB involvement with 90 % sensitivity and 40 % specificity (AUROC 0.732). Conclusions: One-third of patients had proximal SB involvement. Predictive factors were significant weight loss, stricturing behaviour, and ileal involvement at ileocolonoscopy. These data help to select CD patients that benefit the most from performing a CE.

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Comparison of magnetic resonance enterography and video capsule endoscopy in evaluating small bowel disease

Cited by 44 publications

References 20 publications

Capsule endoscopy for small-bowel evaluation in Crohn's disease

Capsule endoscopy for small-bowel evaluation in Crohn's disease

Capsule Endoscopy and Crohn’s Disease

Development of a predictive model of Crohn’s disease proximal small bowel involvement in capsule endoscopy evaluation

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