Comparison of malondialdehyde, nitric oxide, adenosine deaminase and glutathione levels in patients with Entamoeba coli, Enterobius vermicularis, Giardia intestinalis, Demodex spp. positive, hydatid cyst and Toxoplasma gondii serum positive

Kıran, Tuğba Raika; Karaman, Ülkü; Arıcı, Yeliz Kaşko; Yıldız, Sevgi

doi:10.5455/annalsmedres.2019.05.236

Cited by 12 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current work showed direct effect of E. vermicularis on oxidative status in children. The current findings are consistent with study carried out by other researchers 24 who referred that the serum MDA levels were higher in patients with E. vermicularis (p < 0.005) compared to healthy persons. Also, indicated that the highest level of GSH was showed in the healthy persons compared to patients.…”

Section: Biochemical Testssupporting

confidence: 93%

Determining the Oxidative State in Children with Enterobiasis Infection

Nassief¹,

Awwad²,

Nassief³

et al. 2022

IJDDT

View full text Add to dashboard Cite

The objective of current study is determining the oxidative state in children with Enterobiasis infection. The current study was done among children aged 3 years to 10 years in Tikrit city, Iraq. 135 children were used in current work at January 2020 to November 2020. The number of males was 57 and female was 78. The cello tape method was to detect infection of Enterobiasis vermicularis. The findings demonstrated that the levels of Malondialdehyde (MDA) in an infected children show significant (p is less than 0.05) elevated compared with healthy children. The levels of Glutathione (GSH) and catalase in an infected children show significant (p is less than 0.05) reduce compared with healthy children. Otherwise, the levels of IL-2 in an infected children show significant elevated compared with healthy children. So, the study found that there is a direct relationship between E. vermicularis and oxidative status in children with a direct effect on interleukin 2.

show abstract

Section: Biochemical Testssupporting

confidence: 93%

Determining the Oxidative State in Children with Enterobiasis Infection

Nassief¹,

Awwad²,

Nassief³

et al. 2022

IJDDT

View full text Add to dashboard Cite

show abstract

“…In reality, after tissue damage, lipid peroxidation occurred in huge quantities, with MDA being the most prominent result of this process, leading to cell structure disruption, inflammation, and necrosis [81]. Authors [59,82,83] reported that MDA levels were significantly higher in asymptomatic Toxoplasma seropositive patients compared to healthy subjects. The NPs structure of CS was showed to be more effectual for ornamental extract uptake compared with free drug of Kumquat [84].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model

et al. 2021

View full text Add to dashboard Cite

The goal of this study was to compare the effects of kumquat extract and its chitosan nanoparticles on biochemical, histopathological, and parasitological factors in mice infected with Toxoplasma gondii versus spiramycin and control groups. A total of 35 mice, 7 of which were negative control and 28 was infected group, were used in the current study. All mice were sacrificed at 45 day after inoculation. Blood samples were collected. Then, sera Malondialdehyde (MDA), Catalase (CAT), Superoxide Dismutase 3 (SOD3), α-glutathione S-transferases (α-GST), and Interleukin 6 (IL-6) concentrations were measured using ELISA technique. In infected groups, CAT, SOD3, α-GST levels were decreased significantly (P<0.01), while MDA and IL-6 concentrations were significantly increased when compared to negative control (P<0.01). Treatment of infected mice with Kumquat-loaded chitosan nanoparticles were significantly improved (P<0.05) all parameters levels in sera and back them close to the original levels of negative control. The biochemical results are in parallel with histopathological and parasitological results. The findings imply that oxidative stress and parasitological changes may have a role in the aetiology and therapy of toxoplasmosis, particularly when Kumquat-loaded chitosan nanoparticles were used.

show abstract

“…The complex endogenous antioxidant system includes antioxidant enzymes such as superoxide dismutases (SODs), catalase (CAT), glutathione peroxidases (GPxs) and glutathione reductase (GR) [ 42 , 43 ], as well as non-enzymatic compounds such as reduced glutathione (GSH) and uric acid [ 44 , 45 ]. GSH protects the cell against the detrimental effects of endogenous and exogenous oxidants by conjugation of reactive species and detoxification of lipid peroxidation products [ 46 , 47 ]. Moreover, GSH prevents the conversion of hemoglobin into methemoglobin in the oxidation reaction [ 7 , 48 ].…”

Section: Oxidative Stress In Toxoplasma Gondii Infectionmentioning

confidence: 99%

“…Some authors reported a significant increase in the concentration of MDA in the serum of humans with chronic toxoplasmosis. Kiran et al [ 47 ], Al-Kuraishy et al [ 85 ] and Yazar et al [ 53 ] reported that MDA levels were significantly higher in asymptomatic Toxoplasma seropositive patients compared to healthy subjects. There was no correlation between age or gender and the MDA concentration.…”

Section: Oxidative Stress In Toxoplasma Gondii Infectionmentioning

confidence: 99%

Oxidative Stress as a Possible Target in the Treatment of Toxoplasmosis: Perspectives and Ambiguities

Szewczyk-Golec¹,

Pawłowska²,

Wesołowski³

et al. 2021

IJMS

View full text Add to dashboard Cite

Toxoplasma gondii is an apicomplexan parasite causing toxoplasmosis, a common disease, which is most typically asymptomatic. However, toxoplasmosis can be severe and even fatal in immunocompromised patients and fetuses. Available treatment options are limited, so there is a strong impetus to develop novel therapeutics. This review focuses on the role of oxidative stress in the pathophysiology and treatment of T. gondii infection. Chemical compounds that modify redox status can reduce the parasite viability and thus be potential anti-Toxoplasma drugs. On the other hand, oxidative stress caused by the activation of the inflammatory response may have some deleterious consequences in host cells. In this respect, the potential use of natural antioxidants is worth considering, including melatonin and some vitamins, as possible novel anti-Toxoplasma therapeutics. Results of in vitro and animal studies are promising. However, supplementation with some antioxidants was found to promote the increase in parasitemia, and the disease was then characterized by a milder course. Undoubtedly, research in this area may have a significant impact on the future prospects of toxoplasmosis therapy.

show abstract

Comparison of malondialdehyde, nitric oxide, adenosine deaminase and glutathione levels in patients with Entamoeba coli, Enterobius vermicularis, Giardia intestinalis, Demodex spp. positive, hydatid cyst and Toxoplasma gondii serum positive

Cited by 12 publications

References 0 publications

Determining the Oxidative State in Children with Enterobiasis Infection

Determining the Oxidative State in Children with Enterobiasis Infection

Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model

Oxidative Stress as a Possible Target in the Treatment of Toxoplasmosis: Perspectives and Ambiguities

Contact Info

Product

Resources

About