BACKGROUND: Marginal and internal fit are believed to be very crucial guideline in the assessment of ceramic restorations and are a remarkable requirement for the long-term performance of fixed dental prostheses. PURPOSE: Was to assess the effect of different CAD-CAM systems on the marginal and internal adaptation of hybrid ceramic restorations. MATERIALS AND METHODS: Lower right six of a typodont resin cast with a 1.0 mm circumferential chamfer finish line, a 2.0 mm occlusal clearance, and an average of 10-12° convergence angle was prepared. This master die was duplicated to thirty acrylic resin dies milled from PMMA discs using CAD-CAM technique. Vita Enamic monolithic crowns were manufactured using three CAD-CAM systems Ceramill, Zirkonzahn and CEREC systems (n=10). Replica technique procedure was used to assess marginal and internal fit of the fabricated prostheses by placing light body impression material between the master die and the restoration and then measuring its thickness at seven points using digital microscope. RESULTS: Measurements were collected for each group and appropriate statistical analysis was carried out. CONCLUSION: CEREC system showed relatively lower marginal and internal discrepancy in a comparison with the other systems. Therefore, there is a significant difference among the three systems.