Comparison of MB Fraction of Creatine Kinase Mass and Troponin I Serum Levels With Necropsy Findings in Acute Myocardial Infarction

Costa, Thiago Nogueira; Nicolau, José Carlos; Gutierrez, Paulo Sampaio

doi:10.1016/j.amjcard.2007.08.037

Cited by 26 publications

(13 citation statements)

References 10 publications

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“…This finding is in accordance with previous studies which have shown that CK lacks specificity for myocardial cell injury and that the measurement of CK is not sensitive enough to detect micropathology of the heart in cattle 22 . In contrast, CK‐MB, an isoenzyme of CK, which is more specific to the cardiac muscle, has a higher specificity for myocardial cell injury and reportedly correlates well to myocardial infarct size in people 23,24 . In the current study, CK‐MB was not measured, therefore no definitive statement with regard to the diagnostic performance of CK‐MB in cattle using our model can be made.…”

Section: Discussionsupporting

confidence: 88%

“…22 In contrast, CK-MB, an isoenzyme of CK, which is more specific to the cardiac muscle, has a higher specificity for myocardial cell injury and reportedly correlates well to myocardial infarct size in people. 23,24 In the current study, CK-MB was not measured, therefore no definitive statement with regard to the diagnostic performance of CK-MB in cattle using our model can be made.…”

Section: Discussionmentioning

confidence: 87%

“…Flunixin-meglumine f (1.1 mg/kg, IV) was given for pyrexia and alleviation of gastrointestinal pain as needed. Blood was collected from the indwelling jugular catheter at 4,6,8,12,16,20,24,36,48,72, and 80 hours (Group A) and at 12, 24, 36, 48, 72, 96, 120, and 144 hours (Group B) after monensin administration for serum biochemical analyses and cTnI measurement. The blood was divided equally and put into tubes without anticoagulant.…”

Section: Methodsmentioning

confidence: 99%

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Correlation of Serum Cardiac Troponin I and Myocardial Damage in Cattle with Monensin Toxicosis

Varga

Schober

Holloman

et al. 2009

Veterinary Internal Medicne

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Background: Cardiac troponin I (cTnI) is used as a biomarker of myocardial injury in people and small animals. Little is known about the diagnostic use of cTnI in cattle.Hypothesis: Serum cTnI correlates to myocardial function and histopathologic lesions in cattle with monensin-induced myocardial injury.Animals: Ten healthy cows. Methods: Experimental study. Animals received 1 dose of monensin PO; 30 mg/kg (n 5 1) or 40 mg/kg (n 5 1) (Group A) or 50 mg/kg monensin (n 5 8) (Group B) of body weight. Repeated measurements were performed of serum cTnI, biochemistry, and ECG and echocardiography until study termination at 80 (Group A) and 144 hours (Group B) after dosing. Semiquantitative histopathologic examinations of the heart were performed in each cow. A scoring system with regard to the magnitude of myocardial injury was established and a total heart score was compared with maximum cTnI concentration measured after monensin administration. Five hearts from healthy cows served as controls.Results: Increased cTnI (40.07 ng/mL) was found in 9/10 cows. cTnI was significantly associated with left ventricular shortening fraction (r 2 5 0.51; P 5 .02) and myocardial histopathologic lesion score (r 2 5 0.49; P 5 .021). All cows (n 5 7) with evidence of myocardial necrosis had a cTnI concentration ! 1.04 ng/mL.Conclusion and Clinical Importance: cTnI is related to myocardial necrosis and severity of myocardial damage in cattle with monensin toxicosis. cTnI could become a useful diagnostic tool in the noninvasive assessment of myocardial injury in cattle with naturally occurring cardiac disease.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Correlation of Serum Cardiac Troponin I and Myocardial Damage in Cattle with Monensin Toxicosis

Varga

Schober

Holloman

et al. 2009

Veterinary Internal Medicne

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“…Overall, cardiac biomarkers CK , CK‐ MB , troponin I, and troponin T correlated strongly with infarct size and less with LVEF. Peak CK‐MB level was reported to be the superior predictor of histological infarct size in a postmortem study . AUC levels were not complete for both cohorts, and in the GIPS‐III trial, peak CK‐MB was superior to CK‐MB AUC.…”

Section: Discussionmentioning

confidence: 92%

The contemporary value of peak creatine kinase‐MB after ST‐segment elevation myocardial infarction above other clinical and angiographic characteristics in predicting infarct size, left ventricular ejection fraction, and mortality

Hartman

Eppinga

Vlaar

et al. 2016

Clinical Cardiology

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Background Complex multimarker approaches to predict outcome after ST‐elevation myocardial infarction (STEMI) have only considered a single baseline sample, while neglecting easily obtainable peak creatine kinase and creatine kinase‐MB (CK‐MB) values during hospitalization. Methods We studied 476 patients undergoing primary percutaneous coronary intervention for STEMI and cardiac magnetic resonance imaging (CMRI) at 4‐6 months after STEMI. We determined the association with cardiac biomarkers (peak CK‐MB, peak troponin T, N‐terminal pro‐brain natriuretic peptide), clinical and angiographic characteristics with infarct size, and LVEF, followed by association with mortality in 1120 STEMI patients. Results Peak CK‐MB was the strongest predictor for infarct size (P<0.001, R 2=0.60) and LVEF (P<0.001, R 2=0.40). The additional value of clinical and angiographic characteristics was limited. The optimal peak CK‐MB cutpoints, for differentiation among small (<10% of the left ventricle), moderate (≥10%–<30%), and large infarct size (≥30%), were 210 U/L and 380 U/L, respectively. These cutpoints were associated with 90‐day mortality; the hazard ratio for moderate infarct was 2.99 (95% confidence interval [CI]: 1.51‐5.93, P=0.002) and for large infarct 6.53 (95% CI: 3.63‐11.76, P<0.001). Conclusions Classical peak CK‐MB measured during hospitalization for STEMI was superior to other clinical and angiographic characteristics in predicting CMRI‐defined infarct size and LVEF, and should be included and validated in future multimarker studies. Peak CK‐MB cutpoints differentiated among infarct size categories and were associated with increased 90‐day mortality risk.

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“…ere are 4 isoenzymes such as CKMM, CKMB, CKMt, and CKBB. Most of the CKMB (95%) is located in the myocardial cytoplasm, being an important predictor of myocardial damage and correlating with infarct size positively [18,19].…”

Section: Introductionmentioning

confidence: 99%

Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years

Guo

Zhou

Jia

et al. 2019

BioMed Research International

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Age-and sex-specific reference intervals (RIs) for myocardial enzyme activity of children and adolescents are not available in China. Our study aimed to establish age-and gender-related RIs for AST, LDH, CK, and CKMB activity in healthy Chinese Han population aged 1∼<18 years. Healthy Han children and adolescents (n � 6322, 1∼<18 years old) were assessed from completed questionnaires and defined criteria from communities and schools in 5 administrative districts of Jilin Province from September 2017 to December 2018. Measurements of AST, LDH, CK, and CKMB activity were performed on the VITROS 5600 Integrated System. Percentiles of enzyme activity were completed by LMS. RIs were established by Medcalc according to the EP28-A3c guidelines issued by the Clinical and Laboratory Standards Institute. AST declined rapidly during 1∼<6 years and had been subsided during 11∼<18 years, though LDH decreased at a steady rate. CK activity stabilized while CKMB showed a downward trend. Sex differences started after age 12 when males presented higher results. ere were significant differences comparing with domestic and other countries' experiments which applied similar methodologies. Enzymes were associated with age and sex, while age had greater impact. We established age-and sex-specific RIs of serum AST, LDH, CK, and CKMB activities for Chinese children and adolescents using the VITROS 5600 Integrated System for the first time. ese data will lay the groundwork for the next horizon in pediatric RIs as well as improve test result interpretation for pediatric illness.

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Comparison of MB Fraction of Creatine Kinase Mass and Troponin I Serum Levels With Necropsy Findings in Acute Myocardial Infarction

Cited by 26 publications

References 10 publications

Correlation of Serum Cardiac Troponin I and Myocardial Damage in Cattle with Monensin Toxicosis

Correlation of Serum Cardiac Troponin I and Myocardial Damage in Cattle with Monensin Toxicosis

The contemporary value of peak creatine kinase‐MB after ST‐segment elevation myocardial infarction above other clinical and angiographic characteristics in predicting infarct size, left ventricular ejection fraction, and mortality

Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years

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