Comparison of measured oxyhemoglobin saturation and oxygen content with analyzer-calculated values and hand-calculated values obtained in unsedated healthy dogs

Scott, Nancy E.; Haskins, Steve C.; Aldrich, Janet; Rezende, Marlis L.; Gallagher, R; Henderson, Matthew M

doi:10.2460/ajvr.2005.66.1273

Cited by 12 publications

(14 citation statements)

References 25 publications

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“…Furthermore, because calculated SO 2 is based on interpolation of the oxyhemoglobin dissociation curve, errors are likely greater for venous samples than arterial samples, as the pO 2 of venous blood lies on a steep part of the curve, and a very small measurement error will have a larger effect on calculated SO 2 . Nevertheless, SO 2 calculated by either method closely resembles measured SO 2 in healthy dogs with normal temperature, pH, and dyshemoglobin concentrations 4 …”

Section: Introductionsupporting

confidence: 56%

“…When co‐oximetry is not available, SO 2 may be estimated from blood gas analysis using formulas preprogrammed into the analyzer that model the hemoglobin saturation curve. Because those formulas are based on the normal human hemoglobin, the machine‐calculated SO 2 may be higher than actual for normal canine blood 4 . Alternatively, saturation may be determined using formulas based on normal canine hemoglobin via a spreadsheet or calculator.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of venous hemoglobin saturation measurements obtained by in vivo oximetry and calculated from blood gas analysis in critically ill dogs

Walton

Hansen

2021

J Vet Emergen Crit Care

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Objective To compare in vivo central venous hemoglobin saturation measurement (ScvO2) using a fiber optic catheter with saturation calculated from blood gas analysis in critically ill dogs. Design Prospective observational study. Setting University veterinary teaching hospital intensive care unit. Animals A convenience sample of 20 dogs with severe illness. Interventions Dogs were instrumented with either a central venous catheter with an integrated fiber optic cable or a conventional catheter with a fiber optic probe inserted through its distal port. Baseline saturation was measured with the fiber optic system (FSO2), then monitored continuously. Central venous blood was collected for analysis and FSO2 was recorded by the principal investigator (PI) or nursing staff participating in data collection (staff) at baseline and at 1, 2, 3, and 6 hours. Hemoglobin oxygen saturation (SO2) values calculated using human Bohr coefficients were taken directly from the analyzer (GPSO2), and were also calculated using temperature‐correction and canine Bohr coefficients (RSO2). Measurements and Main Results Ninety‐seven paired measurements from 20 dogs were analyzed. FSO2 obtained by the PI (n = 41) had better agreement with both GPSO2 (concordance correlation coefficient ρc = 0.926 vs 0.5562) and RSO2 (ρc = 0.75 for PI vs 0.54) than did staff (n = 56). RSO2 values were always smaller than GPSO2. FSO2 ‐ GPSO2 differences were smaller when measurements were collected by the PI versus Staff (mean difference 0.21 vs −6.6, respectively, P < 0.02). Thirty‐six of 41 FSO2 values obtained by PI were within 5% of GPSO2. Conclusions Concordance between FSO2 and either calculation method was low, but was better when performed by PI. The larger difference between methods when using RSO2 suggests a positive bias by FSO2. Difficulty obtaining stable measurements may have contributed to the poor concordance between methods within Staff.

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Section: Introductionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Comparison of venous hemoglobin saturation measurements obtained by in vivo oximetry and calculated from blood gas analysis in critically ill dogs

Walton

Hansen

2021

J Vet Emergen Crit Care

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“…A potential reason for the high SO 2 % observed may be that the high oxygen affinity Hb (low P 50 ) found in the Greyhound makes Greyhound Hb more likely to remain bound to oxygen, therefore leading to the higher than expected SO 2 %. It is also important to note that, although this instrument b is widely used in hospitals and emergency practices, 26–28 no validation for its use in dogs has been reported. The only parameter that has been validated in vitro is SO 2 % 29 …”

Section: Discussionmentioning

confidence: 99%

Blood gas analysis and cooximetry in retired racing Greyhounds

Zaldívar‐López

Chisnell

Couto

et al. 2011

J Vet Emergen Crit Care

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Objective The purposes of this study were to evaluate the oxygen affinity of hemoglobin (Hb) in healthy retired racing Greyhounds via cooximetry, and to establish reference intervals for blood gases and cooximetry in this breed. Design Prospective clinical study. Setting University Teaching Hospital. Animals Fifty-seven Greyhounds and 30 non-Greyhound dogs. Interventions Venous blood samples were collected from the jugular vein and placed into heparinized tubes. The samples were analyzed within 30 minutes of collection using a blood gas analyzer equipped with a cooximeter. Measurements and Main Results Greyhounds had significantly higher pH, PO2, oxygen saturation, oxyhemoglobin, total Hb, oxygen content, and oxygen capacity and significantly lower deoxyhemoglobin and P50 when compared with non-Greyhound dogs. Conclusion These findings support the fact that this breed is able to carry a higher concentration of total oxygen in the blood. As reported previously, this breed also has lower P50 and, therefore, high oxygen affinity. In light of recent findings suggesting that in certain tissues a high affinity for oxygen is beneficial, this adaptation may be of benefit during strenuous exercise.

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“…Oxygen saturation values for arterial and mixed-venous blood samples were obtained via blood gas analyses. 17 In this study, hypotension was defined as MABP ≤ 60 mm Hg, hypertension was defined as MABP ≥ 90 mm Hg, bradycardia was defined as heart rate ≤ 60 beats/min, hypoventilation was defined as Paco 2 ≥ 45 mm Hg, and acidosis was defined as blood pH ≤ 7.35.…”

Section: Methodsmentioning

confidence: 99%

Hemodynamic influence of acepromazine or dexmedetomidine premedication in isoflurane-anesthetized dogs

Grasso¹,

Ko²,

Weil³

et al. 2015

javma

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Comparison of measured oxyhemoglobin saturation and oxygen content with analyzer-calculated values and hand-calculated values obtained in unsedated healthy dogs

Abstract: Although certain HbO2 and ContO2 values generated by use of the different methods were significantly different, these differences are unlikely to be clinically important in healthy dogs.

Cited by 12 publications

References 25 publications

Comparison of venous hemoglobin saturation measurements obtained by in vivo oximetry and calculated from blood gas analysis in critically ill dogs

Comparison of venous hemoglobin saturation measurements obtained by in vivo oximetry and calculated from blood gas analysis in critically ill dogs

Blood gas analysis and cooximetry in retired racing Greyhounds

Hemodynamic influence of acepromazine or dexmedetomidine premedication in isoflurane-anesthetized dogs

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