Comparison of mechanical behavior among the extrapulmonary arteries from rats

Drexler, Elizabeth S.; Quinn, Tim; Slifka, Andrew J.; McCowan, Christopher N.; Bischoff, Jeffrey E.; Wright, J.E.; Ivy, D. Dunbar; Shandas, Robin

doi:10.1016/j.jbiomech.2006.03.010

Cited by 19 publications

(22 citation statements)

References 33 publications

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“…We determined that the PA wall was circumferentially stiffer in both age groups implying a more dominant circumferential fiber orientation. Previous studies of the PA biaxial behavior in other animals report similar directional properties [37]. The PA wall exhibited a maximum of about 40% circumferential and 40-70% longitudinal strains under equibiaxial stress.…”

Section: Discussionsupporting

confidence: 57%

“…The regional mechanical behavior of the aorta and its postnatal growth adaptations has been investigated in several previous studies [16,18,20,[33][34][35]. While there have been a few studies of pulmonary artery mechanics [36][37][38][39], to date there have not been any other rigorous investigation of the regional pulmonary arterial mechanical behavior as a function of growth. We determined that the PA wall was circumferentially stiffer in both age groups implying a more dominant circumferential fiber orientation.…”

Section: Discussionmentioning

confidence: 99%

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Regional Structural and Biomechanical Alterations of the Ovine Main Pulmonary Artery During Postnatal Growth

Fata¹,

Carruthers

Gibson³

et al. 2013

Journal of Biomechanical Engineering

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The engineering foundation for novel approaches for the repair of congenital defects that involve the main pulmonary artery (PA) must rest on an understanding of changes in the structure-function relationship that occur during postnatal maturation. In the present study, we quantified the postnatal growth patterns in structural and biomechanical behavior in the ovine PA in the juvenile and adult stages. The biaxial mechanical properties and collagen and elastin fiber architecture were studied in four regions of the PA wall, with the collagen recruitment of the medial region analyzed using a custom biaxial mechanical-multiphoton microscopy system. Circumferential residual strain was also quantified at the sinotubular junction and bifurcation locations, which delimit the PA. The PA wall demonstrated significant mechanical anisotropy, except in the posterior region where it was nearly isotropic. Overall, we observed only moderate changes in regional mechanical properties with growth. We did observe that the medial and lateral locations experience a moderate increase in anisotropy. There was an average of about 24% circumferential residual stain present at the luminal surface in the juvenile stage that decreased to 16% in the adult stage with a significant decrease at the bifurcation, implying that the PA wall remodels toward the bifurcation with growth. There were no measurable changes in collagen and elastin content of the tunica media with growth. On average, the collagen fiber recruited more rapidly with strain in the adult compared to the juvenile. Interestingly, the PA thickness remained constant with growth. When this fact is combined with the observed stable overall mechanical behavior and increase in vessel diameter with growth, a simple Laplace Law wall stress estimate suggests an increase in effective PA wall stress with postnatal maturation. This observation is contrary to the accepted theory of maintenance of homeostatic stress levels in the regulation of vascular function and suggests alternative mechanisms regulate postnatal somatic growth. Understanding the underlying mechanisms, incorporating important structural features during growth, will help to improve our understanding of congenital defects of the PA and lay the basis for functional duplication in their repair and replacement.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Regional Structural and Biomechanical Alterations of the Ovine Main Pulmonary Artery During Postnatal Growth

Fata¹,

Carruthers

Gibson³

et al. 2013

Journal of Biomechanical Engineering

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“…The motivation derives from membrane inflation tests on vasculature (Drexler et al 2003(Drexler et al , 2007Slifka et al 2006) that were conducted in order to quantify material changes between health and disease (hypoxia).…”

Section: Methodsmentioning

confidence: 99%

“…Several different modes of deformation have been used to interrogate the nonlinear, anisotropic properties of cardiovascular tissue including uniaxial/biaxial extension , suction/aspiration (Ohashi et al 2005), inflation (Humphrey et al 1987;Hsu et al 1994;Zhang et al 2005;Slifka et al 2006;Drexler et al 2007), compression and indentation (Cox et al 2006). Membrane inflation has been used by numerous investigators, in which mechanical loading is decoupled from specimen gripping and the mechanical integrity of the tissue in the region of interest is not compromised.…”

Section: Introductionmentioning

confidence: 99%

Quantifying nonlinear anisotropic elastic material properties of biological tissue by use of membrane inflation

Bischoff

Drexler²,

Slifka³

et al. 2009

Computer Methods in Biomechanics and Biomedical Engineering

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Determination of material parameters for soft tissue frequently involves regression of material parameters for nonlinear, anisotropic constitutive models against experimental data from heterogeneous tests. Here, parameter estimation based on membrane inflation is considered. A four parameter nonlinear, anisotropic hyperelastic strain energy function was used to model the material, in which the parameters are cast in terms of key response features. The experiment was simulated using finite element (FE) analysis in order to predict the experimental measurements of pressure versus profile strain. Material parameter regression was automated using inverse FE analysis; parameter values were updated by use of both local and global techniques, and the ability of these techniques to efficiently converge to a best case was examined. This approach provides a framework in which additional experimental data, including surface strain measurements or local structural information, may be incorporated in order to quantify heterogeneous nonlinear material properties.

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“…It is usually used to test thin metallic or polymer membranes (Çakmak et al, 2014;Rivlin and Saunders, 1951;Tsakalakos and Jankowski, 1986), calculating stress by assuming a spherical deformation cap. The same process has been transposed to test many biological tissues such as skin (Tonge et al, 2013), fetal membrane (Joyce, 2009;Perrini et al, 2013), pericardium (Hildebrandt et al, 1969), sclera (Myers et al, 2010), arteries (Drexler et al, 2007), but also liver capsule (Brunon et al, 2011). For capsules encompassing pressurized organs such as liver or kidney, bulge test is particularly fitted to determine mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Characterizing liver capsule microstructure via in situ bulge test coupled with multiphoton imaging

Jayyosi

Coret

Bruyère-Garnier

2016

Journal of the Mechanical Behavior of Biomedical Materials

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The characterization of biological tissue at the microscopic scale is the starting point of many applications in tissue engineering and especially in the development of structurally based constitutive models. In the present study, focus is made on the liver capsule, the membrane encompassing hepatic parenchyma, which takes a huge part in liver mechanical properties. An in situ bulge test experiment under a multiphoton microscope has been developed to assess the microstructure changes that arise with biaxial loading. Multiphoton microscopy allows to observe the elastin and collagen fiber networks simultaneously. Thus a description of the microstructure organization of the capsule is given, characterizing the shapes, geometry and arrangement of fibers. The orientation of fibers is calculated and orientation distribution evolution with loading is given, in the case of an equibiaxial and two non equibiaxial loadings, thanks to a circular and elliptic set up of the bulge test. The local strain fields have also been computed, by the mean of a photobleaching grid, to get an idea of what the liver capsule might experience when subjected to internal pressure. Results show that strain fields present some heterogeneity due to anisotropy. Reorientation occurs in non equibiaxial loadings and involves fibers layers from the inner to the outer surface as expected. Although there is a fiber network rearrangement to accommodate with loading in the case of equibiaxial loading, there is no significant reorientation of the main fibers direction of the different layers.

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Comparison of mechanical behavior among the extrapulmonary arteries from rats

Cited by 19 publications

References 33 publications

Regional Structural and Biomechanical Alterations of the Ovine Main Pulmonary Artery During Postnatal Growth

Regional Structural and Biomechanical Alterations of the Ovine Main Pulmonary Artery During Postnatal Growth

Quantifying nonlinear anisotropic elastic material properties of biological tissue by use of membrane inflation

Characterizing liver capsule microstructure via in situ bulge test coupled with multiphoton imaging

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