One of the most important parts of medical care is the endoscopy sector, like digestive endoscopy, which has gained extensive importance and is assumably going to increase in the future. We aimed to analyse and synthesize the impact of digestive endoscopy upon the environment and the possible measures that can be taken to minimize the negative effects of endoscopy related to environmental pollution and human health exposure. The means through which digestive endoscopy produces pollution have been analysed, considering the frame and the base of the last stage of a medical or pharmaceutical product. This research suggests a strategy for improving the impact of this sector on the sustainability of the healthcare system based on four pillars comprising the use of eco-friendly substances, materials, and devices, reducing the consumption of water and all possible devices and energy, reusing those components that can be safely reinserted in the endoscopic circuit and recycling everything that is possible. The conclusions highlight that there is a great need to take control of medical practice, admitting the impact that the healthcare system has on global warming and greenhouse gas emissions, acknowledging the limited assets and wealth of the planet, and applying standards and scales of sustainability that can lead to responsible services for patients.