Comparison of meglumine sodium diatrizoate, lopamidol, and lohexol for coronary angiography and ventriculography

Murdock, Challon J.; Davis, Michael J.; Ireland, Mark A.; Gibbons, Fran A.; Cope, Geoffrey D.

doi:10.1002/ccd.1810190306

Cited by 13 publications

(2 citation statements)

References 20 publications

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“…These effects have been explained by factors that include high osmolality, high sodium concentration, chemical toxicity of the contrast molecule and calcium binding properties of the chelates used for some of these agents [1,6]. Contrast agents with a lower osmolality (ionic dimeric or nonionic monomeric agents) have much less pronounced hemodynamic effects [1,2,[7][8][9][10][11][12]. This has been assumed to reduce the risk of provoking myocardial ischemia during coronary angiography or ventriculography [13].…”

Section: Introductionmentioning

confidence: 99%

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Bergstra

Dijk

Brekke³

et al. 2000

Cathet. Cardiovasc. Intervent.

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A crossover study was performed to compare the hemodynamic effects of the iso-osmolar contrast agent iodixanol (Visipaque) 320 mg I/ml to those of the low-osmolar iohexol (Omnipaque) 350 mg I/ml. The main hypothesis was that iodixanol and iohexol would affect left ventricular end-diastolic pressure (LVEDP) to different degrees. In 48 patients with reduced cardiac function (mean ejection fraction 33. 4%), one ventricular injection was performed with each contrast medium. Ventricular, aortic and right atrial pressures and heart rate were measured continuously. Cardiac output (using Fick's principle) and systemic vascular resistance were calculated. LVEDP increased with both agents, but significantly less after iodixanol than after iohexol (P < 0.01), also in subgroups of patients in whom baseline LVEDP was severely increased and in whom 3-vessel disease was present. Immediate changes in variables reflecting vasodilatation were similar with both agents. In conclusion, both contrast agents influenced hemodynamics during ventriculography, but iodixanol had significantly less influence on LVEDP than did iohexol.

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Section: Introductionmentioning

confidence: 99%

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Bergstra

Dijk

Brekke³

et al. 2000

Cathet. Cardiovasc. Intervent.

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“…The best CM for coronary arteriography is the medium that produces the smallest risk of VF and the smallest changes in CF. In clinical coronary arteriography it has been shown that nonionic monomeric CM induce less risk of VF and fewer changes in C F than ionic monomeric CM (4, 23,25).…”

mentioning

confidence: 99%

Effect on Cardiac Contractile Force from Addition of Cations and Oxygen to Iohexol

Besjakov¹,

Bååth²,

Almén³

et al. 1993

Acta Radiol

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The coronary arteries of the isolated rabbit heart were perfused with different contrast media (CM). The effects on cardiac contractile force (CF) from enriching iohexol solutions with sodium, calcium, potassium, magnesium and oxygen were investigated. The effects were studied during normal and reduced perfusion pressure; the latter was intended to simulate flow conditions distal to proximal stenotic processes of the coronary arteries. By adding the above mentioned cations to iohexol (175 mg I/ml) the smallest influence on C F was found when the CM contained 30 mM NaCI, 0.3 mM CaCI,, 0.9 mM KCI and 0.3 mM MgCI, and this influence on C F was significantly less than caused by iohexol with 30 mM NaCl (p

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Effects of an ionic versus a nonionic low osmolar contrast agent on the thrombotic complications of coronary angioplasty

Piessens¹,

Stammen²,

Vrolix³

et al. 1993

Cathet. Cardiovasc. Diagn.

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An increasing body of evidence suggests that the potential for thrombotic complications is greater with nonionic than with ionic contrast agents. This is a particularly important consideration in the highly thrombogenic setting of percutaneous transluminal coronary angioplasty (PTCA). To explore this issue further, 500 consecutive patients undergoing PTCA were prospectively randomized to receive the low osmolality ionic ioxaglate or the nonionic agent iohexol. The number of acute thrombotic in-laboratory events was significantly less in the ioxaglate than in the iohexol group (8 versus 18; P < 0.05), but there was no significant difference between the 2 groups as regards the number of out-of-laboratory acute rethrombotic events. With multivariate analysis, use of the nonionic agent rather than the ionic agent emerged as an independent predictor of acute in-laboratory rethrombosis. These data suggest that, in the performance of PTCA, an ionic, rather than a nonionic, should be the preferred contrast agent.

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Comparison of meglumine sodium diatrizoate, lopamidol, and lohexol for coronary angiography and ventriculography

Cited by 13 publications

References 20 publications

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Hemodynamic effects of iodixanol and iohexol during ventriculography in patients with compromised left ventricular function

Effect on Cardiac Contractile Force from Addition of Cations and Oxygen to Iohexol

Effects of an ionic versus a nonionic low osmolar contrast agent on the thrombotic complications of coronary angioplasty

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