Comparison of mesoporous fractal characteristics of silica-supported organocatalysts derived from bipyridine-proline and resultant effects on the catalytic asymmetric aldol performances

Developing effective intelligent nanocarriers is highly desirable for fluorescence imaging and therapeutic applications but remains challenging. Using a vinyl-grafted BMMs (bimodal mesoporous SiO2 materials) as a core and PAN ((2-aminoethyl)-6-(dimethylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione))-dispersed dual pH/thermal-sensitive poly(N-isopropylacrylamide-co-acrylic acid) as a shell, PAN@BMMs with strong fluorescence and good dispersibility were prepared. Their mesoporous features and physicochemical properties were extensively characterized via XRD patterns, N2 adsorption–desorption analysis, SEM/TEM images, TGA profiles, and FT-IR spectra. In particular, their mass fractal dimension (dm) features based on SAXS patterns combined with fluorescence spectra were successfully obtained to evaluate the uniformity of the fluorescence dispersions, showing that the dm values increased from 2.49 to 2.70 with an increase of the AN-additive amount from 0.05 to 1%, along with the red shifting of their fluorescent emission wavelength from 471 to 488 nm. The composite (PAN@BMMs-I-0.1) presented a densification trend and a slight decrease in peak (490 nm) intensity during the shrinking process. Its fluorescent decay profiles confirmed two fluorescence lifetimes of 3.59 and 10.62 ns. The low cytotoxicity obtained via in vitro cell survival assay and the efficient green imaging performed via HeLa cell internalization suggested that the smart PAN@BMM composites are potential carriers for in vivo imaging and therapy.

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Comparison of mesoporous fractal characteristics of silica-supported organocatalysts derived from bipyridine-proline and resultant effects on the catalytic asymmetric aldol performances

Abstract: The relationships between the fractal evolution and catalytic behavior of the resultant catalysts were deeply explored via SAXS method and other characterizations. The applicability and reliability of fractal theory are therefore proved.

Cited by 2 publications

References 54 publications

Fractal features of pH-sensitive bimodal mesoporous silica-supported bipyridine-proline organocatalysts with core-shell structure and their application in asymmetric aldol reaction

Fractal features of pH-sensitive bimodal mesoporous silica-supported bipyridine-proline organocatalysts with core-shell structure and their application in asymmetric aldol reaction

Dispersion Performances of Naphthalimides Doped in Dual Temperature- and pH-Sensitive Poly (N-Isopropylacrylamide-co-acrylic Acid) Shell Assembled with Vinyl-Modified Mesoporous SiO2 Core for Fluorescence Cell Imaging

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