Comparison of metal concentrations in rat tibia tissues with various metallic implants

Okazaki, Yoshimitsu; Gotoh, Emiko; Manabe, Takeshi; Kobayashi, Kihei

doi:10.1016/j.biomaterials.2004.01.064

Cited by 144 publications

(112 citation statements)

References 23 publications

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“…Among titanium alloys employed as metallic implant materials, Ti-6Al-4V has been widely used in dental and medical fields. Although this alloy is still widely used in dental and medical fields, some concerns such as toxicity of V and Al and high elastic modulus, have been reported [6][7][8] . Surface roughness and topography can greatly affect the proliferation and protein synthesis of osteoblast cells that are cultured on a metal substrate characteristics in the healing of bone 21,22) .…”

Section: Surface Characterization and Roughness Testmentioning

confidence: 99%

“…However because of needs to improve its mechanical properties, titanium alloys such as Ti-6Al-4V, Ti-6Al-7Nb, have also been used for dental and orthopedic material [3][4][5] . 1) Although titanium alloys are still widely used in medicine, some concern has been expressed over its use since it appears that small amounts of both vanadium and aluminum, released in the human body, induce possible cytotoxic effect and neurological disorders, respectively [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility of Ti-8Ta-3Nb alloy with fetal rat calvarial cells

Cho

Cui

Kim

et al. 2006

J Korean Acad Periodontol

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Section: Surface Characterization and Roughness Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatibility of Ti-8Ta-3Nb alloy with fetal rat calvarial cells

Cho

Cui

Kim

et al. 2006

J Korean Acad Periodontol

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“…Among the α-β-type Ti alloys, Ti-6Al-4V has been extensively used for various orthopedic applications. Another α-β-type Ti alloy, Ti-15Zr-4Nb-4Ta, has been developed in Japan as a highly biocompatible material for long-term biomedical applications [5][6][7][8] and is now standardized in the Japanese Industrial Standard JIS T 7401-4 [9].…”

Section: Introductionmentioning

confidence: 99%

Comparisons of immersion and electrochemical properties of highly biocompatible Ti–15Zr–4Nb–4Ta alloy and other implantable metals for orthopedic implants

Okazaki

Nagata

2012

Science and Technology of Advanced Materials

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Metal release from implantable metals and the properties of oxide films formed on alloy surfaces were analyzed, focusing on the highly biocompatible Ti-15Zr-4Nb-4Ta alloy. The thickness and electrical resistance (R p ) of the oxide film on such an alloy were compared with those of other implantable metals. The quantity of metal released during a 1-week immersion test was considerably smaller for the Ti-15Zr-4Nb-4Ta than the Ti-6Al-4V alloy. The potential (E 10 ) indicating a current density of 10 µA cm −2 estimated from the anodic polarization curve was significantly higher for the Ti-15Zr-4Nb-4Ta than the Ti-6Al-4V alloy and other metals. Moreover, the oxide film (4-7 nm thickness) formed on the Ti-15Zr-4Nb-4Ta surface is electrochemically robust. The oxide film mainly consisted of TiO 2 with small amounts of ZrO 2 , Nb 2 O 5 and Ta 2 O 5 that made the film electrochemically stable. The R p of Ti-15Zr-4Nb-4Ta was higher than that of Ti-6Al-4V, i.e. 0.9 cm 2 in 0.9% NaCl and 1.3 cm 2 in Eagle's medium. This R p was approximately five-fold higher than that of stainless steel, which has a history of more than 40 years of clinical use in the human body. Ti-15Zr-4Nb-4Ta is a potential implant material for long-term clinical use. Moreover, E 10 and R p were found to be useful parameters for assessing biological safety.Keywords: Ti-15Zr-4Nb-4Ta alloy, implantable metals, passive film, field-emission transmission electron microscopy, angle-resolved x-ray photoelectron spectroscopy, electrochemical stability evaluation

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“…11 Despite these relatively inert qualities, titanium has been shown to be released in its most stable Ti(IV) oxidation state at micromolar concentrations into the tissues surrounding metal implants by various mechanisms including wear, corrosion, and biological activity. 12 Once released into the systemic circulation, the metal ions bind to serum proteins and form haptens or hapten-like complexes, which can be transported to and accumulate in distal organs. 13 Indeed, homogenates of remote organs and clinically retrieved tissues from patients with titanium alloy total hip arthroplasty have indicated that significantly increased titanium concentrations can occur in the liver, kidney, spleen, and lymph nodes.…”

mentioning

confidence: 99%

Titanium uptake, induction of RANK‐L expression, and enhanced proliferation of human T‐lymphocytes

Cadosch

Sutanto

Chan

et al. 2009

Journal Orthopaedic Research

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There is increasing evidence that titanium ions are released from orthopedic implants by biocorrosion. The aim of this study was to investigate titanium uptake by human T-lymphocytes and its effects on phenotype and proliferation. Freshly isolated human nonadherent peripheral blood mononuclear cells (NA-PBMC), were exposed to TiCl 4 [Ti(IV)]. Bioavailability and distribution of Ti(IV) in T-lymphocytes was determined by energy-filtered electron microscopy (EFTEM). The effects of Ti(IV) challenge on nonactivated and PHA-activated cells were assessed by flow cytometric analysis of surface markers, RANK-L production, and proliferation assays. EFTEM colocalized Ti(IV) with phosphorus in the nucleus, ribosomes, cytoplasmic membranes, and the surface membrane of T-lymphocytes. Ti(IV) increased significantly the expression of CD69, CCR4, and RANK-L in a concentration-dependent manner. Titanium enters T-lymphocytes through a currently unknown mechanism and binds to phosphorus-rich cell structures. Titanium influences phenotype and function of T-lymphocytes, resulting in activation of a CD69þ and CCR4þ T-lymphocyte population and secretion of RANK-L. These results strongly suggest the involvement of titanium ions challenged T-lymphocytes in the complex pathophysiological mechanisms of aseptic loosening of orthopedic implants. ß

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Comparison of metal concentrations in rat tibia tissues with various metallic implants

Cited by 144 publications

References 23 publications

Biocompatibility of Ti-8Ta-3Nb alloy with fetal rat calvarial cells

Biocompatibility of Ti-8Ta-3Nb alloy with fetal rat calvarial cells

Comparisons of immersion and electrochemical properties of highly biocompatible Ti–15Zr–4Nb–4Ta alloy and other implantable metals for orthopedic implants

Titanium uptake, induction of RANK‐L expression, and enhanced proliferation of human T‐lymphocytes

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