Comparison of metastasis between early-onset and late-onset gastric signet ring cell carcinoma

Zhou, Qiang-ping; Ge, Yong-Hua; Liu, Chengyuan

doi:10.1186/s12876-020-01529-z

“…Efared et al [ 49 ] found that in 183 patients with gastric cancer, the mean age of SRCC patients was lower than that of non-SRCC patients, which was consistent with the preliminary analysis of our systematic review. In addition, an increasing number of early-onset gastric cancers [ 50 ] have been detected in people younger than 45 years old, and patients with early-onset SRCC are more prone to lymphatic vessel invasion [ 51 ]. Early-onset patients have fewer surgical complications than late-onset patients because the previous group receives chemotherapy in a larger proportion, which is conducive to a better prognosis [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, an increasing number of early-onset gastric cancers [ 50 ] have been detected in people younger than 45 years old, and patients with early-onset SRCC are more prone to lymphatic vessel invasion [ 51 ]. Early-onset patients have fewer surgical complications than late-onset patients because the previous group receives chemotherapy in a larger proportion, which is conducive to a better prognosis [ 51 , 52 ]. Consistently, the results of this study are also indicative of a lower HR in SRCC patients receiving chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features and Prognostic-Related Risk Factors of Gastric Signet Ring Cell Carcinoma: A Meta-Analysis

Guo

¹

,

Wang

²

,

Tian

³

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Gastric signet ring cell carcinoma (SRCC) has shown a growth growing trend worldwide, but its clinicopathological features and prognostic-related risk factors have not been systematically studied. This systematic review was devoted to this. Method. PubMed, Embase, Cochrane Library, and Web of Science databases were retrieved, and retrospective cohort studies comparing clinicopathological features and related risk factors in SRCC patients were included. Results. In SRCC patient population, males were more than females (male, OR = 1.38 , 95% CI: 1.20-1.60); N3 patients were more than N0-2 patients (N0-2, OR = 3.19 , 95% CI: 1.98-5.15); M1 patients were more than M0 patients (M0, OR = 3.30 , 95% CI: 1.88-5.80); patients with tumor > 5 cm were more than those with tumor ( ≤ 5 cm, OR = 7.36 , 95% CI: 1.33-40.60). Patients with age < 60 years ( age ≥ 60 years, OR = 1.03 , 95% CI: 1.01-1.05), lymphatic vessel invasion (no, OR = 1.74 , 95% CI: 1.03-2.45), T2 (T1, OR = 1.17 , 95% CI: 1.07-1.28) and T4 (T1, OR = 2.55 , 95% CI: 2.30-2.81) stages, and N1 (N0, OR = 1.73 , 95% CI: 1.08-2.38), N2 (N0, OR = 2.24 , 95% CI: 1.12-3.36), and N3 (N0, OR = 3.45 , 95% CI: 1.58-5.32) stages had higher hazard ratio (HR). Conclusion. SRCC may occur frequently in male. Age, lymphatic vessel invasion, TN, and M stage may be risk factors for poor prognoses of SRCC patients.

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“…More common in women, advanced disease stages at diagnosis [299][300][301][302] Higher grades, advanced disease stages, signet ring cell or diffuse histology 246,253,306 ; fewer somatic mutations in TP53 and more somatic mutations in MUC5B, BANP, CDH1 and TGFBR1 (reFs. 72 .…”

Section: Stomach Cancermentioning

confidence: 99%

Is early-onset cancer an emerging global epidemic? Current evidence and future implications

Ugai

¹

,

Sasamoto

²

,

Lee

³

et al. 2022

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Cancer is a multifactorial disease that most commonly affects people ≥50 years of age. However, evidence indicates that the incidence of cancers of various organs (including those of the breast, colorectum, endometrium, oesophagus, extrahepatic bile duct, gallbladder, head and neck, kidney, liver, bone marrow (multiple myeloma (MM)), pancreas, prostate, stomach and thyroid) has been rising in adults <50 years of age in many parts of the world 1-13 . This trend is also observed in analyses using Global Cancer Observatory (GLOBOCAN; https://gco.iarc.fr/) data (Fig. 1 provides data on selected countries; more comprehensive data are provided in Supplementary Table 1). We herein use the term 'early-onset' to describe cancers diagnosed in adults <50 years of age, and a contrasting term, 'later-onset' , for cancers diagnosed in those ≥50 years of age. Cancers diagnosed during childhood and adolescence (<20 years of age) are out of the scope of this Review.The rise of early-onset cancer has considerable personal, societal and economic implications. Survivors of early-onset cancers have a higher risk of long-term health problems such as infertility, cardiovascular disease and secondary cancers [14][15][16] . Owing to this increasing cancer burden among young adults, which might be referred to as the 'early-onset cancer epidemic' , the US National Cancer Institute listed this phenomenon as a research priority in one of its 'Provocative Questions' for 2020-2021 (reF. 17).Differences in epidemiology and clinical, pathological, and molecular characteristics clearly exist between early-onset and later-onset cancers, although these features are not likely to change dramatically at exactly 50 years of age 18 . Furthermore, early-onset cancer in any given organ is not a homogeneous entity but rather encompasses a variable range of clinical and pathological features 18,19 . We acknowledge the limitations of applying a dichotomy at 50 years of age, although we selected this cut-off point to enable consistent collection and interpretation of current evidence on early-onset cancers. In reality, we also need to consider heterogeneity within Is early-onset cancer an emerging global epidemic? Current evidence and future implications

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“…Indeed, the female cases accounts for 44.9% and 57.9% in our NQSQS cohort and SEER-API cohort, respectively. Furthermore, EOGC patients were reported to be characterized with poorer differentiation, higher signet-ring cell tumor frequency ( 17 ), more advanced nodal metastasis and distant metastasis ( 18 , 19 ). Consistently, our data showed that the signet-ring cell carcinoma comprised 33.9% cases in NQSQS cohort and 42.1% in SEER-API cohort.…”

Section: Discussionmentioning

confidence: 99%

Multi‑institutional development and validation of a nomogram to predict prognosis of early-onset gastric cancer patients

Liu

¹

,

Li

²

,

Zhang

³

et al. 2022

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BackgroundEarly-onset gastric cancer (EOGC, ≤45 years old) is characterized with increasing incidence and more malignant phenotypes compared with late-onset gastric cancer, which exhibits remarkable immune cell infiltration and is potential immunotherapeutic population. Till now, restricted survival information of EOGC is available due to limited case numbers. This study established a novel nomogram to help evaluate cancer-specific survival (CSS) of EOGC patients who underwent gastrectomy, and may provide evidence for predicting patients’ survival.MethodsWe retrospectively enrolled a cohort containing 555 EOGC cases from five independent medical centers in China, among which 388 cases were randomly selected into a training set while the other 167 cases were assigned into the internal validation set. Asian or Pacific Islander (API) patients diagnosed with EOGC during 1975-2016 were retrieved from the SEER database (n=299) and utilized as the external validation cohort. Univariate and multivariate analyses were conducted to test prognostic significances of clinicopathological factors in the training set. Accordingly, two survival nomogram models were established and compared by concordance index (C-index), calibration curve, receiver operating characteristics (ROC) curves and decision curve analyses (DCA).ResultsThe 5-year CSS rate of training cohort was 61.3% with a median survival time as 97.2 months. High consistency was observed on calibration curves in all three cohorts. Preferred nomogram was selected due to its better performance on ROC and DCA results. Accordingly, a novel predicative risk model was introduced to better stratify high-risk EOGC patients with low-risk patients. In brief, the 5-year CSS rates for low-risk groups were 92.9% in training set, 83.1% in internal validation set, 89.9% in combined NQSQS cohort, and 85.3% in SEER-API cohort. In contrast, the 5-year CSS rates decreased to 38.5%, 44.3%, 40.5%, and 36.9% in the high-risk groups of the four cohorts above, respectively. The significant survival difference between high-risk group (HRG) and low-risk group (LRG) indicated the precise accuracy of our risk model. Furthermore, the risk model was validated in patients with different TNM stages, respectively. Finally, an EOGC web-based survival calculator was established with public access, which can help predict prognosis.ConclusionsOur data provided a precise nomogram on predicting CSS of EOGC patients with potential clinical applicability.

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Comparison of metastasis between early-onset and late-onset gastric signet ring cell carcinoma

Cited by 13 publications

References 25 publications

Clinicopathological Features and Prognostic-Related Risk Factors of Gastric Signet Ring Cell Carcinoma: A Meta-Analysis

Clinicopathological Features and Prognostic-Related Risk Factors of Gastric Signet Ring Cell Carcinoma: A Meta-Analysis

Is early-onset cancer an emerging global epidemic? Current evidence and future implications

Multi‑institutional development and validation of a nomogram to predict prognosis of early-onset gastric cancer patients

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