2007
DOI: 10.1111/j.1748-5827.2007.00319.x
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Comparison of methods for determining platelet numbers and volume in cavalier King Charles spaniels

Abstract: CKCS [corrected] with macrothrombocytosis have low platelet counts on impedance cell counters, laser cell counters and microscopic estimation. CKCS [corrected] with low platelet counts may have a normal platelet crit detected by a quantitative buffy coat analyser and thus a normal circulating platelet mass.

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Cited by 19 publications
(24 citation statements)
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“…The QBC platelet count, which is really more an indicator of plateletcrit, should provide the best estimate of total platelet mass in CKCS dogs of the methods used. QBC platelet counts were usually normal in CKCS in another study 4 . Only 1 of 17 CKCS dogs had a decreased platelet count by the QBC method while 14 of 41 had <100 × 10 9 platelets/L by an impedance cell counter and 11 of 41 had <100 × 10 9 platelets/L by a laser cell counter.…”
Section: Discussionmentioning
confidence: 80%
“…The QBC platelet count, which is really more an indicator of plateletcrit, should provide the best estimate of total platelet mass in CKCS dogs of the methods used. QBC platelet counts were usually normal in CKCS in another study 4 . Only 1 of 17 CKCS dogs had a decreased platelet count by the QBC method while 14 of 41 had <100 × 10 9 platelets/L by an impedance cell counter and 11 of 41 had <100 × 10 9 platelets/L by a laser cell counter.…”
Section: Discussionmentioning
confidence: 80%
“…Several methods have been proposed to improve the evaluation of platelet mass, especially in the feline species . Measurement of the plateletcrit (PCT) with the quantitative buffy coat (QBC) IDEXX Vet Autoread hematology analyzer could better evaluate the platelet mass in dogs with macrothrombocytopenia, especially in some canine breeds . A scoring system to evaluate platelet mass based on the size of platelet clumps on feline blood smears has also been proposed .…”
Section: Introductionmentioning
confidence: 99%
“…Thus two parameters are used to distinguish red cells and platelets. However Bertazzolo and others (2007) show that large platelets may also be misclassified using this methodology. Quantitative buffy coat analysis (QBC) measures the width of different cell layers after centrifugation with a cylinidrical float which lengthens cell layers, and staining with a fluorescent dye.…”
mentioning
confidence: 91%
“…blood film examination or mailing to a commercial laboratory) is performed when required. Bertazzolo and others (2007) compare methods for determining platelet counts and platelet volume in cavalier King Charles Spaniels (CKCSs) and provide a helpful review of the methodology used by various analysers to count platelets and distinguish them from red cells. Their study clearly illustrates the problems encountered in obtaining platelet counts in this breed.…”
mentioning
confidence: 99%