Comparison of microwave-assisted and conventional preparations of cyclic imides

Microwave-Assisted NBS Bromination ofp-Iminotoluenes: Preparation of New Alcohol, Mercapto, and Amino Protection Groups

“…First, we developed a laboratory microwave reactor that can be used as standard laboratory equipment for reactions that require high energy, and second, this equipment was recently used to prepare large quantities of cyclic imides in short reaction times and good yields. [32] Because of these two advances in our laboratory, the starting material for the preparation of new protection groups was already available in large quantities.…”

One Scaffold, Many Possibilities – Copper(I)‐Catalyzed Azide–Alkyne Cycloadditions, Strain‐Promoted Azide–Alkyne Cycloadditions, and Maleimide–Thiol Coupling of Ruthenium(II) Polypyridyl Complexes

“…Optimum reaction conditions were obtained through the modification of the previously reported conditions for organic maleimides . Surprisingly, during the screening of the different reaction conditions, we observed that reactions in a one‐pot microwave setup yielded the desired closed maleimide either in excellent yields or not at all. Therefore, the two‐step method was preferred for further work as it proceeds reliably.…”

Microwave-promoted synthesis of cyclic imides

“…In some cases, the amount of solvent can be reduced to a few drops, necessary only to moisten the reaction mixture, thereby obtaining high quantities of pure cyclic imides in a matter of hours. 80,86,100,101 Although one advantage of DMF as solvent is its capability to retain water formed during the course of the reaction, hence avoiding the need for a water separator, 102 the employment of molecular sieves can improve the results as is the case of the synthesis of quinolinimides from quinolinic anhydride. 81 Other neutral, acid or basic solvents with different polarity, have proved useful.…”