Comparison of modified two‐point dixon and chemical shift encoded MRI water‐fat separation methods for fetal fat quantification

Giza, Stephanie A.; Miller, Michael R.; Parthasarathy, Prasiddha; Vrijer, Barbra de; McKenzie, Charles A.

doi:10.1002/jmri.25929

Cited by 9 publications

(6 citation statements)

References 39 publications

(76 reference statements)

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“…Other than CSE-MRI, a couple of other MRI sequences could also facilitate better characterization of fatty lesions, Dixon sequences rely on the difference in resonance frequency between water and fat, unlike fat suppression sequences. Hence, Dixon sequences could generate water-only, fat-only, in-phase and out-of-phase images in a single acquisition ( 13 , 14 ). Kuetting et al used multipoint Dixon technique to non-invasively distinguish chylous and nonchylous ascites and pleural effusions ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

The diagnostic value of morphological features of fat deposition of sacroiliac joint steatosis in axial spondyloarthritis

Zhao,

Lin,

Liu

et al. 2023

Front. Med.

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BackgroundFindings of fatty lesions in the context of other imaging manifestations, especially bone marrow edema and erosions can effectively assist in the diagnosis of axSpA. Chemical shift-encoded MRI is a sequence which allows for the quantification of fat signal and has been applied in the imaging evaluation of the SIJ in axSpA. The objective of this study was to investigate the diagnostic performance of morphological features of fatty lesions visualized by CSE-MRI in the imaging evaluation of SIJ in axSpA.MethodsFatty lesions with morphological features (subchondral, homogeneity and distinct border) were assessed and recorded as a binary variable in each quadrant of the SIJ. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated for different morphological features as well as the anatomical distribution in patients with nr-axSpA and r-axSpA. T1-weighted images and CSE-MRI fat fraction maps were directly compared in the recognition of different morphological features.ResultsEighty-two patients [non-SpA (n = 21), nr-axSpA (n = 23), r-axSpA (n = 38)] with lower back pain (LBP) were enrolled. Presence of the three morphological features of fatty lesions had a specificity of 90.48% in axSpA. The sensitivities of being subchondral, homogeneity and distinct border were 52.17, 39.13 and 39.13% in nr-axSpA on T1-weighted images. For patients with r-axSpA, the sensitivities reached 86.84, 76.32 and 57.89%. No significant difference was found in the distribution of fatty lesions between T1-weighted images and CSE-MRI. However, CSE-MRI fat fraction maps could detect significantly more fatty lesions with homogeneity (p = 0.0412) and distinct border (p = 0.0159) than T1-weighted images in the sacroiliac joint, but not subchondral lesions (p = 0.6831).ConclusionThe homogeneity and distinct border are more relevant for the diagnosis of axSpA. Moreover, CSE-MRI could detect more typical morphological features of fatty lesions than T1-weighted images in showing these two features. The presence of all three features was more likely to be indicative of axSpA.

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Section: Discussionmentioning

confidence: 99%

The diagnostic value of morphological features of fat deposition of sacroiliac joint steatosis in axial spondyloarthritis

Zhao,

Lin,

Liu

et al. 2023

Front. Med.

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“…It is frequently used in clinical applications, while the dual‐echo Dixon sequence is more widely available on clinical systems. These two sequences were shown to have comparable reliability in fat quantification 38 . Compared to acquisition with two TEs, the multiecho Dixon method typically acquires six TEs thus results in lower SNR/resolution and/or longer scan time, which is a large disadvantage in abdominal imaging due to severe motion 39 .…”

Section: Discussionmentioning

confidence: 99%

“…These two sequences were shown to have comparable reliability in fat quantification. 38 Compared to acquisition with two TEs, the multiecho Dixon method typically acquires six TEs thus results in lower SNR/resolution and/or longer scan time, which is a large disadvantage in abdominal imaging due to severe motion. 39 In addition, the fundamental contrast differences between dual-echo Dixon and multiecho Dixon sequences is another important factor that the multiecho Dixon images were not included in this study but to further promote this DL-based method in clinical applications, training, and testing on the multiecho Dixon images is inevitable in the next steps.…”

Section: Limitationsmentioning

confidence: 99%

Automated Measurement of Pancreatic Fat Deposition on Dixon MRI Using nnU‐Net

Lin

Wang

et al. 2022

Magnetic Resonance Imaging

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Background: Pancreatic fat accumulation may cause or aggravate the process of acute pancreatitis, β-cell dysfunction, T2DM disease, and even be associated with pancreatic tumors. The pathophysiology of fatty pancreas remains overlooked and lacks effective imaging diagnostics. Purpose: To automatically measure the distribution of pancreatic fat deposition on Dixon MRI in multicenter/population datasets using nnU-Net models. Study Type: Retrospective. Population: A total of 176 obese/nonobese subjects (90 males, 86 females; mean age, 27.2 AE 19.7) were enrolled, including a training set (N = 132) and a testing set (N = 44).

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“…While this sequence has recognized limitations of sensitivity to T2* effects (caused by e.g. iron) and incomplete fat spectrum modelling (MRI fat signal at multiple frequencies due to the complex chemical structure of triglyceride) [34], recent work has demonstrated that these effects do not cause bias in estimates of fat fraction with modified 2point Dixon in fTSAT [35]. However it should be noted that Giza et al did demonstrate biases in estimates of fat fraction with modified 2-point Dixon in other tissues including the liver [35].…”

Section: Discussionmentioning

confidence: 99%

Measuring fetal adipose tissue using 3D water-fat magnetic resonance imaging: a feasibility study

Giza

Olmstead

McCooeye

et al. 2018

The Journal of Maternal-Fetal & Neonatal Medicine

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Comparison of modified two‐point dixon and chemical shift encoded MRI water‐fat separation methods for fetal fat quantification

Abstract: 4 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018.

Cited by 9 publications

References 39 publications

The diagnostic value of morphological features of fat deposition of sacroiliac joint steatosis in axial spondyloarthritis

The diagnostic value of morphological features of fat deposition of sacroiliac joint steatosis in axial spondyloarthritis

Automated Measurement of Pancreatic Fat Deposition on Dixon MRI Using nnU‐Net

Measuring fetal adipose tissue using 3D water-fat magnetic resonance imaging: a feasibility study

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