Comparison Of Mometasone Twisthaler With Fluticasone Diskus For Treatment Effects On Small Airway Impairment And Aiway Inflammation In Patients With Asthma

Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma

“…Forty-two citations represent 16 RCTs [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] (N = 22 748 patients), 15 of which evaluated SMART as a combination therapy with budesonide and formoterol in a dry-powder inhaler. Characteristics of the included studies appear in eTables 1 through 4 in the Supplement.…”

“…Fourteen RCTs 20,[23][24][25][26][27][28][29][30][31][32][33][34][35] compared SMART vs inhaled corticosteroids and LABA as the controller therapy and SABA as the quick relief. Nine trials 20,[23][24][25][26][27][28][29][30] (n = 12 902) used the same comparative dose of inhaled corticosteroids in both groups and all but 1 RCT 20 fit into the age group of 12 years or older. O'Byrne et al 20 enrolled patients aged 4 to 80 years and provided subgroup data 31 for patients aged 4 to 11 years.…”

“…One trial 30 further specified persistent asthma severity as moderate to severe. Nine trials enrolled patients with symptomatic asthma, 20,[23][24][25]28,30,[32][33][34] 2 trials 29,35 enrolled patients regardless of presence of asthma symptoms, and 4 trials 24,26,28,30 specified that enrolled patients had uncontrolled asthma. Most trials used budesonide and formoterol in a dry-powder inhaler in both groups.…”

“…Two trials compared combined budesonide and formoterol in a dry-powder inhaler and quick relief with combined fluticasone and salmeterol. 23,28 One trial 26 compared combined beclomethasone and formoterol in both groups.…”