2005
DOI: 10.1016/j.bbrc.2005.05.163
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Comparison of MukB homodimer versus MukBEF complex molecular architectures by electron microscopy reveals a higher-order multimerization

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Cited by 53 publications
(65 citation statements)
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“…with MukB triggers intra-or intermolecular cross-linking. Intramolecular cross-linking of two MukB heads yields rings with stoichiometry B2F2E4 (bottom left), whereas intermolecular cross-linking generates higher ordered MukB structures as described elsewhere (19). Because MukE latches both arms of MukB to a MukF dimer, the B2F2E4 complex is unable to interact with DNA.…”
Section: Discussionmentioning
confidence: 83%
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“…with MukB triggers intra-or intermolecular cross-linking. Intramolecular cross-linking of two MukB heads yields rings with stoichiometry B2F2E4 (bottom left), whereas intermolecular cross-linking generates higher ordered MukB structures as described elsewhere (19). Because MukE latches both arms of MukB to a MukF dimer, the B2F2E4 complex is unable to interact with DNA.…”
Section: Discussionmentioning
confidence: 83%
“…Therefore, association of F2E4 with MukB would cross-link MukB either intramolecularly to form rings (Fig. 4) or intermolecularly to form filaments or rosette-like structures (19). Alternatively, binding of F2E2 to MukB or the loss of a MukE dimer from the B2F2E4 complex would allow for a switch from a locked to a functional remodeling complex (Fig.…”
Section: Discussionmentioning
confidence: 99%
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“…Similarly, the MukBEF complex remains stably associated with the E. coli chromosome following cell lysis, suggesting that this complex also serves a scaffolding role that organizes the bacterial chromosome into a higher-order structure (71). Electron microscopy studies have revealed that MukBEF complexes can aggregate to form rosettes (72), and high-resolution structural studies suggest that this process may occur through MukF/E mediated bridging of MukB dimers (73).…”
Section: Discussionmentioning
confidence: 99%
“…A structural analysis indicated that MukF is a kleisin (35). Accordingly, MukBEF, but not MukB, was found to form multimolecular rosette-like and fiber-like structures in the absence of ATP or DNA (36).…”
mentioning
confidence: 95%