Comparison of multi-tissue aging between human and mouse

Abstract

With the rapid growth of the aging population, exploring the biological basis of aging and related molecular mechanisms has become an important topic in modern scientific research. Aging can cause multiple organ function attenuations, leading to the occurrence and development of various age-related metabolic, nervous system, and cardiovascular diseases. In addition, aging is closely related to the occurrence and development of tumors. Although a number of studies have used various mouse models to study aging, further research is needed to associate mouse and human aging at the molecular level. In this paper, we systematically assessed the relationship between human and mouse aging by comparing multi-tissue age-related gene expression sets. We compared 18 human and mouse tissues, and found 9 significantly correlated tissue pairs. Functional analysis also revealed some terms related to aging in human and mouse. And we performed a crosswise comparison of homologous age-related genes with 18 tissues in human and mouse respectively, and found that human Brain_Cortex was significantly correlated with Brain_Hippocampus, which was also found in mouse. In addition, we focused on comparing four brain-related tissues in human and mouse, and found a gene– GFAP –related to aging in both human and mouse.

Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition

“…Regardless, our results support this finding and previous observations of lower MOTS-c plasma levels in aged mice, but are in contrast to reported murine skeletal muscle age-associated decline in MOTS-c levels [14]. This may reflect inherent differences between human and mouse skeletal muscle aging [33,34], but also load (B) and maximal leg press load relative to CSA (C) was correlated with muscle MOTS-c expression in older men. Significance was determined using linear regression or one-way ANOVA.…”

Skeletal Muscle Transcriptome Alterations Related to Physical Function Decline in Older Mice

“…With the ubiquitous use of the mouse model in aging, mechanistic, and pharmaceutical research, understanding both parallels and differences in age-associated gene expression with humans is a necessary future undertaking. A recent comparative study of gene array data of skeletal muscle in mice and humans revealed 249 homologous overlapping age-related genes (Zhuang, 2019), but noted 6333 differentially expressed skeletal muscle genes between under 30 year old and over 65 year old humans-very similar to our finding of 6587 in 6-month to 28-month old mice. It is important to note that, as we have uncovered in this study, the age of the older mice plays a key role in differential gene expression.…”

A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging

“…Transcriptome change is a significant molecular signature of aging and serves as an essential factor in the aging-associated functional decline across organs ( Benayoun et al, 2019 ; Braun et al, 2016 ; Schaum et al, 2019 ; Stoeger et al, 2019 ; Yu et al, 2014 ; Zahn et al, 2007 ). Several earlier studies have profiled and analyzed age-correlated gene expression in different organs in rodents ( Barns et al, 2014 ; Benayoun et al, 2019 ; Braun et al, 2016 ; de Magalhães et al, 2009 ; Ori et al, 2015 ; Schaum et al, 2019 ; Stoeger et al, 2019 ; Yu et al, 2014 ; Zahn et al, 2007 ; Zhuang et al, 2019 ) and humans ( Ahadi et al, 2020 ; Glass et al, 2013 ; Wang et al, 2018 ; Yang et al, 2015 ; Zhuang et al, 2019 ). The majority of the genes altered during aging are associated with inflammatory responses ( Benayoun et al, 2019 ; Schaum et al, 2019 ; Stegeman and Weake, 2017 ), highlighting chronic inflammation as a hallmark of aging.…”