2024
DOI: 10.1002/cnr2.2004
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Comparison of mutation landscapes of pretreatment versus recurrent squamous cell carcinoma of the oral cavity: The possible mechanism of resistance to standard treatment

Tongchai Payungwong,
Krittaya Angkulkrerkkrai,
Amphun Chaiboonchoe
et al.

Abstract: BackgroundA high recurrent rate of oral squamous cell carcinoma (OSCC) is a major concern in head and neck cancer treatment. The study of the genetic mutation landscape in recurrent OSCC may provide information on certain mutations associated with the pathobiology and treatment response of the OSCC.AimWe investigated the mutation landscape of matched pretreatment and recurrent tumors to understand the influence of genetic mutations on the pathobiology and clinical outcomes in OSCC.Methods and ResultsWe sequenc… Show more

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