Comparison of Mycobacterium lentiflavum and Mycobacterium avium-intracellulare Complex Lymphadenitis

Jiménez-Montero, Beatriz; Baquero-Artigao, Fernando; Saavedra-Lozano, Jesús; Tagarro-García, Alfredo; Blázquez‐Gamero, Daniel; Cilleruelo-Ortega, María J.; Ramos-Amador, José Tomás; Galé-Ansó, Inés; Marín, Natalia; Gómez-García, Raquel; Santiago-García, Begoña; Garrido, Jesús; López, Goosen Luis

doi:10.1097/inf.0000000000000007

Cited by 22 publications

(7 citation statements)

References 40 publications

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“…haemophilum in Israel and The Netherlands [24], and M . lentiflavum in Spain [24, 25]. It is of interest to note that none of the eight children was vaccinated with the BCG and that all cases were diagnosed after 2007, year of the cessation of compulsory BCG vaccination in France, suggesting possible cross protection by BCG to mycobacteriosis.…”

Section: Discussionmentioning

confidence: 99%

Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

et al. 2016

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BackgroundNontuberculous mycobacteria (NTM) are environmental organisms associated with a range of infections. Reports of NTM epidemiology are mainly focused on pulmonary infections and isolations, and extrapulmonary infections are less frequently described.MethodsWe conducted a retrospective study of NTM infections at the Bordeaux University Hospital, France, between January 2002 and December 2013. We used the microbiologic component of the American Thoracic Society/Infectious Diseases Society of America's pulmonary NTM disease criteria to define cases of pulmonary NTM, and patients with isolates from a normally sterile site were classified as having extrapulmonary disease.ResultsIn our setting, 170 patients were included. Pulmonary cases predominated (54.1%), followed by skin and soft tissue infections (22.9%), disseminated cases (10.6%), lymphadenitis (7.7%), bone and joint infections (2.9%) and the remaining 1.8% catheter-related infections. Overall, 16 NTM species were isolated. Mycobacterium avium (31.8%) and M. intracellulare (20%) were the most common species identified, followed by M. marinum (13.5%), M. kansasii (10.6%), M. xenopi (9.4%), rapidly growing mycobacteria (9.4%) and other slowly growing mycobacteria (5.3%). In general, NTM isolates were largely prevalent in people older than 50 (62.4%); patients aged 1–10 year-old exclusively yielded M. avium from lymph nodes, almost cases having being diagnosed after 2007. Among the 121 patients with complete follow-up, 78 (64.5%), 24 (19.8%), and 19 (15.7%) were cured, experienced relapse, or died, respectively.ConclusionIn our study, extrapulmonary NTM infections represented almost half of cases, consisting mainly in skin and soft tissue infections. The increase lymphadenitis cases in children after 2007 could be linked to the cessation of mandatory BCG vaccination in France. We observed similar cure rates (64%) between pulmonary and extrapulmonary infections.

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Section: Discussionmentioning

confidence: 99%

Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

et al. 2016

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“…The incidence of this condition is low, which contributes to delays in diagnosis; diagnosis typically follows several therapeutic failures with systemic antibiotics [6] , [7] , [8] , [9] , as occurred in the cases described here. The majority of cases are caused by M. avium complex [6] , [7] , [8] , [9] , although the spectrum of disease-causing NTM species is broad [10] , [11] , [12] , [13] . NTMs are ubiquitous, but a direct link between their environmental prevalence and their involvement in mycobacterial lymphadenitis has not been established [8] .…”

Section: Discussionmentioning

confidence: 99%

Cervicofacial lymphadenitis due to Mycobacterium mantenii: rapid and reliable identification by MALDI-TOF MS

Nebreda-Mayoral

Andrés

Carretero

et al. 2018

New Microbes and New Infections

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“…Plus récemment Mycobacterium lentiflavum et Mycobacterium haemophilum ont été décrites comme des mycobactéries émergentes responsables d'adénites chez les enfants [53,54].…”

Section: Autres Mycobactériesunclassified

Diagnostic des adénites infectieuses

Melenotte

Edouard

Lépidi

et al. 2015

La Revue de Médecine Interne

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Comparison of Mycobacterium lentiflavum and Mycobacterium avium-intracellulare Complex Lymphadenitis

Abstract: M. lentiflavum is an emerging pathogen producing NTM lymphadenitis in Madrid.

Cited by 22 publications

References 40 publications

Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

Nontuberculous Mycobacterial Infections in a French Hospital: A 12-Year Retrospective Study

Cervicofacial lymphadenitis due to Mycobacterium mantenii: rapid and reliable identification by MALDI-TOF MS

Diagnostic des adénites infectieuses

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