2021
DOI: 10.1016/j.scitotenv.2021.145442
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Comparison of nanoparticle-selenium, selenium-enriched yeast and sodium selenite on the alleviation of cadmium-induced inflammation via NF-kB/IκB pathway in heart

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Cited by 92 publications
(44 citation statements)
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“…Selenium-containing supplements proved to be effective in blocking cytokine-induced upregulation of NF-κB and iNOS, thus reducing stress-related NO inflammatory levels in the hypothalamus and hippocampus of an animal model [ 125 ]. Selenium feed supplements in chickens alleviated cardiac injury, splenic lymphocytes, and splenic tissue damage associated with Cd-derived or Hg-derived inflammation, via the production of NO through the NF-κB/iNOS pathway [ 126 , 127 ].…”
Section: Cardiovascular Diseasementioning
confidence: 99%
“…Selenium-containing supplements proved to be effective in blocking cytokine-induced upregulation of NF-κB and iNOS, thus reducing stress-related NO inflammatory levels in the hypothalamus and hippocampus of an animal model [ 125 ]. Selenium feed supplements in chickens alleviated cardiac injury, splenic lymphocytes, and splenic tissue damage associated with Cd-derived or Hg-derived inflammation, via the production of NO through the NF-κB/iNOS pathway [ 126 , 127 ].…”
Section: Cardiovascular Diseasementioning
confidence: 99%
“…For example, Na 2 SeO 3 , the most widely used Se form, exhibits excellent chemo-preventive and anticancer features [ 19 ], but SeNPs has been shown to be comparatively better as anticancer agent than Na 2 SeO 3 [ 20 ]. Besides, many studies have demonstrated that SeNPs had stronger biological activities like antioxidant activity, antidiabetic activity, improving reproduction and antagonizing cadmium-induced cardiotoxicity than Na 2 SeO 3 [ 21 , 22 , 23 , 24 ]. Therefore, SeNPs has been considered as a good candidate for replacement of other Se forms in clinical practice [ 17 , 25 ].…”
Section: Introductionmentioning
confidence: 99%
“…These results were consistent with the experiments as follows. Zhang et al found that SeY antagonizes the inflammatory damage caused by Cd to chicken cardiomyocytes through the NF-κB signaling pathway [ 52 ], and Wang et al showed that the addition of Se could effectively downregulated the high-expression of NF-κB gene in chicken kidney tissue caused by Cd exposure [ 34 ]. These results demonstrated that the addition of SeY could effectively inhibit the phosphorylation of IκBα to prevent NF-κB from entering the nucleus and mitigate the inflammatory response.…”
Section: Discussionmentioning
confidence: 99%