Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites

Misra, Superb K.; Mohn, Dirk; Brunner, Tobias J.; Stark, Wendelin J.; Philip, Sheryl E.; Roy, Ipsita; Salih, Vehid; Knowles, Jonathan C.; Boccaccını, Aldo R.

doi:10.1016/j.biomaterials.2007.12.040

Cited by 319 publications

(298 citation statements)

References 40 publications

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“…In addition, it can be seen that bioglass particles are well-dispersed and embedded into the polymer matrix (Fig. 4c) which in turn improve the load transferral across the filler-matrix interface and amend the composite stiffness [35]. However, the larger particles were not fully incorporated into the matrix (Fig.…”

Section: Thermal Analysismentioning

confidence: 98%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

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Section: Thermal Analysismentioning

confidence: 98%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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“…Bone tissue engineering is one of the most exciting future clinical applications of bioactive glasses. Both micron-sized and recently nanoscale particles [23,44,45] are considered in this application field, which includes also the fabrication of composite materials, e.g., combination of biodegradable polymers and bioactive glass [38,[46][47][48][49][50], as discussed in detail in §3.2. Bioactive silicate glasses exhibit several advantages in comparison to other bioactive ceramics, e.g., sintered hydroxyapatite, in tissue engineering applications.…”

Section: Figurementioning

confidence: 99%

“…Extensive work has been also carried out to investigate the cellular response to bioactive glass containing composites concerning composition, particle concentration and particle size effect in vitro and in vivo [46][47][48][161][162][163][164]166,[169][170][171]174]. For example, Lu et al [179] showed that for PLGA/bioactive glass films (0, 10, 25, 50 wt %), the growth, mineralization and differentiation of human osteoblast-like SaOS-2 cells (Figure 15), as well as the kinetics of Ca-P layer formation and the resulting Ca-P chemistry were dependent on BG content.…”

Section: Bioactive Glass Containing Composite Scaffoldsmentioning

confidence: 99%

“…This finding might have also consequences for the vascularization and angiogenic properties of composite scaffolds, as discussed in section §4. To our knowledge, Misra et al [48] were the first who incorporated bioactive glass nanoparticles (30-50 nm) of composition matching the 45S5 BG composition into degradable matrices (in their case P(3HB) was used) and compared their thermal, mechanical, microstructural, bioactive and cell biological properties with those of conventional, micron-sized BG (5 µm) containing composites. The addition of bioactive glass nanoparticles (n-BG) enhanced the Young's modulus by 50-100% to values of 1.2 and 1.6 GPa, compared to both pure polymer film and the corresponding micro-sized BG (m-BG) containing films (10, 20, 30 wt %).…”

Section: Bioactive Glass Containing Composite Scaffoldsmentioning

confidence: 99%

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Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Chatzistavrou

2011

Bioactive Glasses

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Traditionally, bioactive glasses have been used to fill and restore bone defects. More recently, this category of biomaterials has become an emerging research field for bone tissue engineering applications. Here, we review and discuss current knowledge on porous bone tissue engineering scaffolds on the basis of melt-derived bioactive silicate glass compositions and relevant composite structures. Starting with an excerpt on the history of bioactive glasses, as well as on fundamental requirements for bone tissue engineering scaffolds, a detailed overview on recent developments of bioactive glass and glass-ceramic scaffolds will be given, including a summary of common fabrication methods and a discussion on the microstructural-mechanical properties of scaffolds in relation to human bone (structure-property and structure-function relationship). In addition, ion release effects of bioactive glasses concerning osteogenic and angiogenic responses are addressed. Finally, areas of future research are highlighted in this review.

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“…Its bioactivity is associated with the formation of a carbonated hydroxyapatite layer (HCA) on its surface, similar to the bone mineral. [29,30] Glass-ceramics with crystalline or semicrystalline structures are produced by the transformation of the glass into a ceramic. [10] The sol-gel glasses offer several advantages compared with the melt-delivered glasses.…”

Section: Introductionmentioning

confidence: 99%

Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

Moskalewicz

Zych

Łukaszczyk

et al. 2017

Metall Mater Trans A

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In this study, microporous composite sol-gel glass/polyetheretherketone (SGG/PEEK) coatings were produced on the Ti-13Nb-13Zr titanium alloy by electrophoretic deposition. Coatings with different levels of high open porosity were developed by introducing SGG particles of varying diameters into the PEEK matrix. The microstructure of the coatings was characterized by electron microscopy and X-ray diffractometry. The coatings with 40-50 lm thickness were composed of semicrystalline SGG particles consisting of hydroxyapatite, CaSiO 3 , some Ca 2 SiO 4 , and an amorphous phase containing Ca, Si, P, and O, homogeneously embedded in a semicrystalline PEEK matrix. The size of SGG particles present in the coatings strongly influenced the formation of microcracks and their adhesion to the underlying substrate. Microscratch tests showed that the coating containing SGG particles with a diameter smaller than 45 lm and open porosity of 45 pct exhibited good adhesion to the titanium alloy substrate, much better than the coating containing particles with a diameter smaller than 85 lm and total open porosity equal to 48 pct. The corrosion resistance was investigated in Ringer's solution at a temperature of 310 K (37°C) for a pH equal to 7.4 and in deaerated solutions with the use of open-circuit potential, potentiodynamic polarization, and electrochemical impedance spectroscopy. The SGG/PEEK-coated alloy indicated better electrochemical corrosion resistance compared with the uncoated alloy.

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Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass® composites

Cited by 319 publications

References 40 publications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

Electrophoretic Deposition, Microstructure, and Corrosion Resistance of Porous Sol–Gel Glass/Polyetheretherketone Coatings on the Ti-13Nb-13Zr Alloy

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