Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain

Gottlieb, Michael; Njie, Abdoulie

doi:10.1017/cem.2016.370

Cited by 7 publications

(2 citation statements)

References 8 publications

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“…Thirty studies ( Berry and Hutchinson, 1988 ; Stein et al, 1996 ; Birbara et al, 2003 ; Ruoff et al, 2003 ; Coats et al, 2004 ; Pallay et al, 2004 ; Peloso et al, 2004 ; Kanayama et al, 2005 ; Perrot et al, 2006 ; Pareek et al, 2009 ; Skljarevski et al, 2009 ; Skljarevski et al, 2010a ; Skljarevski et al, 2010b ; Buynak et al, 2010 ; Hale et al, 2010 ; Katz et al, 2011 ; Biondi et al, 2013 ; Kivitz et al, 2013 ; Rauck et al, 2014 ; Tiseo et al, 2014 ; Friedman et al, 2015 ; Rauck et al, 2015 ; Baron et al, 2016 ; Bedaiwi et al, 2016 ; Gottlieb and Njie, 2016 ; Konno et al, 2016 ; Sanga et al, 2016 ; Miki et al, 2018 ; Dakin et al, 2020 ; Markman et al, 2020 ) were included in this NMA ( Supplementary Figure S1 ). Nine groups were included in the main network analysis: placebo (Pla), antidepressant (ADP), anti-NGF (ANGF), acetanilide antipyretic analgesics (AP), nonsteroidal anti-inflammatory drugs (NSAIDs), weak opioids (WO), strong opioids (SO), a combination of AP and WO (cAPWO), and a combination of NSAIDs and skeletal muscle relaxants (cNSMRs).…”

Section: Resultsmentioning

confidence: 99%

Is Targeting Nerve Growth Factor Antagonist a New Option for Pharmacologic Treatment of Low Back Pain? A Supplemental Network Meta-Analysis of the American College of Physicians Guidelines

Cao

Guo

et al. 2021

Front. Pharmacol.

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Objective: It has been found that targeting nerve growth factor antagonists (ANGF) have excellent effects in the treatment of chronic pain, and the current pharmacologic treatments have very limited effects on low back pain (LBP). Thus we conducted this network meta-analysis (NMA) to study the efficacy and safety of ANGF for the treatment of LBP, and to guide for clinical practice and further research.Method: PubMed, Scopus, Embase, CNKI, and the Cochrane Library were searched from January 1980 to March 2021. A frequentist framework network meta-analysis with a random-effect model was performed. Ranking effects were calculated by surface under the cumulative ranking analysis (SUCRA) and clusterank analysis.Results: This NMA identified 30 studies, involving 9,508 patients with LBP. ANGF reported both superior effect on pain relief {SUCRA 82.1%, SMD 0.89, 95% CI [(0.26,1.51)]} and function improvement {SUCRA 77.3%, SMD 0.93, 95% CI [(0.27,1.58)]} than placebo, and did not showed any higher risk of treatment-emergent adverse effects {RR 1.11, 95% CI [(0.97,1.27)]} or serious adverse effects {RR 1.03, 95% CI [(0.54,1.97)]}, but it was associate with a special risk of rapidly progressive osteoarthritis. ANGF displayed the greatest potential to be the most effective and safest treatment (cluster-rank value for function improvement and safety: 4266.96, for pain relief and safety: 4531.92).Conclusion: ANGF could relieve pain and improve function effectively and are superior to other traditional drugs recommended by guidelines. Although no significant difference in tolerability and safety between ANGFs and placebo was found, the rapid progression of original osteoarthritis which may be related to the use of ANGFs still needs special attention and furtherly verification by clinical trials.Systematic Review Registration: PROSPERO, identifier [CRD42021258033].

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Section: Resultsmentioning

confidence: 99%

Is Targeting Nerve Growth Factor Antagonist a New Option for Pharmacologic Treatment of Low Back Pain? A Supplemental Network Meta-Analysis of the American College of Physicians Guidelines

Cao

Guo

et al. 2021

Front. Pharmacol.

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“…In a study conducted by Gottlieb et al, Opioid, myorelaxant, and placebo were given by oral route along with NSAID for patients with low back pain [7]. There was no difference in the treatments given for pain activity but there was a significant difference in the opioid group in terms of side effect.…”

Section: Discussionmentioning

confidence: 99%

Research on the comparison of Non-steroidal anti-inflammatory drugs (NSAID) and opioids in low back pain

Katipoğlu

Kaykısız

2019

Disaster Emerg Med J

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InTrodUcTIon: Opioids and Non-steroidal anti-inflammatory drugs (NSAID) are used to manage low back pain. However, it has been reported in some researches that opioids have fewer side effects than NSAID. MeTHods: Patient files of all the patients admitted to the emergency department of Ufuk University ethics committee on 23.03.2018 and applied with severe nontraumatic low back pain between 01.01.2015 and 01.01.2016 were examined retrospectively. It was aimed to evaluate the efficacy of these two drugs in the treatment of pain by evaluating the responses of these patients with visual analogue scale scales. resULTs: A total of 138 patients among 911 patients experiencing low back pain were included in the study. 81 patients received 75 mg of diclofenac sodium therapy alone, 57 patients received only Petidin hydrochloride treatment. 64 (46.4%) of the patients were male and 74 (53.6%) were female. It was found that there was no statistically significant correlation between pain scores of 75 mg of diclofenac sodium imide treatment applied and Pethidine hydrochloride applied patient groups (p > 0.05). There was no statistically significant correlation between pain scores and genders of 75 mg of diclofenac sodium imide treatment applied and Pethidine hydrochloride applied patient groups (p > 0.05). The difference between patients' referral scores and pain scores after 45 minutes (75 mg diclofenac sodium imide and petidine hydrochloride imide) were found to be statistically insignificant (p > 0.05). There was no statistically significant difference in the analyzed results of the efficacy of 75 mg diclofenac sodium treatment related to gender (p > 0.05). There was no statistically significant difference in the analyzed results of the efficacy of Pethidine hydrochloride treatment related to sex (p > 0.05). concLUsIons: Opioids have fewer side effects than NSAIDs in short period management of the pain, and they may be used for low back pain management in emergency services instead of NSAIDs.

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Low dose ketamine use in the emergency department, a new direction in pain management

Pourmand

Mazer‐Amirshahi

Royall

et al. 2017

The American Journal of Emergency Medicine

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Comparison of naproxen with cyclobenzaprine, oxycodone-acetaminophen, and placebo for the treatment of acute low back pain

Cited by 7 publications

References 8 publications

Is Targeting Nerve Growth Factor Antagonist a New Option for Pharmacologic Treatment of Low Back Pain? A Supplemental Network Meta-Analysis of the American College of Physicians Guidelines

Is Targeting Nerve Growth Factor Antagonist a New Option for Pharmacologic Treatment of Low Back Pain? A Supplemental Network Meta-Analysis of the American College of Physicians Guidelines

Research on the comparison of Non-steroidal anti-inflammatory drugs (NSAID) and opioids in low back pain

Low dose ketamine use in the emergency department, a new direction in pain management

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