Comparison of nasal sprays and irrigations in the delivery of topical agents to the olfactory mucosa

Lam, Kent; Tan, Bruce K.; Lavin, Jennifer; Meen, Eric; Conley, David B.

doi:10.1002/lary.24239

Cited by 43 publications

(38 citation statements)

References 21 publications

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“…In recent years, nasal irrigation have played a significant role in the medical management of CRS and other sinonasal disorders. The efficacy of nasal irrigations is likely explained by their ability to effectively distribute topical agents to the sinonasal cavities, remove debris and secretions from these areas, and ultimately enhance mucociliary clearance and nasal patency . Saline solutions in both hypertonic and isotonic formulations are commonly employed as topical therapies.…”

Section: Discussionmentioning

confidence: 99%

“…irrigations is likely explained by their ability to effectively distribute topical agents to the sinonasal cavities, remove debris and secretions from these areas, and ultimately enhance mucociliary clearance and nasal patency. 19,28,29 Saline solutions in both hypertonic and isotonic formulations are commonly employed as topical therapies. Although strong evidence exists regarding the efficacy and safety of saline irrigations to improve subjective and objective measures of nasal function, the use of nasal irrigations to affect olfactory performance has not been well characterized.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the importance of the ionic microenvironment in olfactory physiology, there are few studies that evaluate the general effects of the olfactory mucus on human olfactory sensitivity . In clinical practice, nasal irrigations provide an increasingly prevalent mechanism to alter characteristics of the olfactory mucus, including the ionic microenvironment, due to their effective reach of the olfactory cleft and increasing popularity among patients with sinonasal complaints . The objective of this investigation was thus to determine the effects of nasal irrigations on immediate olfactory thresholds following their performance with varying compositions of potassium, sodium, and calcium.…”

Section: Introductionmentioning

confidence: 99%

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Effect of ionic compositions in nasal irrigations on human olfactory thresholds

Lam¹,

Conley²,

Liu³

et al. 2014

The Laryngoscope

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of ionic compositions in nasal irrigations on human olfactory thresholds

Lam¹,

Conley²,

Liu³

et al. 2014

The Laryngoscope

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“…This focused dose will have the benefits of quicker onset of action, lower systemic side effects, and being more efficacious at lower doses. 46,47 More and more studies have demonstrated that the dosage at the diseased site, rather than the total dose, should be used as the predictor of clinical outcomes. 48 In addition, the initial site of drug deposition has an important effect on its bioavailability and associated therapeutic effectiveness.…”

Section: Discussionmentioning

confidence: 99%

Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

Xi¹,

Yuan²,

April³

et al. 2015

IJN

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Background Despite the prevalence of rhinosinusitis that affects 10%–15% of the population, current inhalation therapy shows limited efficacy. Standard devices deliver <5% of the drugs to the sinuses due to the complexity of nose structure, secluded location of the sinus, poor ventilation, and lack of control of particle motions inside the nasal cavity. Methods An electric-guided delivery system was developed to guide charged particles to the ostiomeatal complex (OMC). Its performance was numerically assessed in an MRI-based nose–sinus model. Key design variables related to the delivery device, drug particles, and patient breathing were determined using sensitivity analysis. A two-stage optimization of design variables was conducted to obtain the best performance of the delivery system using the Nelder-Mead algorithm. Results and discussion The OMC delivery system exhibited high sensitivity to the applied electric field and electrostatic charges carried by the particles. Through the synthesis of electric guidance and point drug release, the new delivery system eliminated particle deposition in the nasal valve and turbinate regions and significantly enhanced the OMC doses. An OMC delivery efficiency of 72.4% was obtained with the optimized design, which is one order of magnitude higher than the standard nasal devices. Moreover, optimization is imperative to achieve a sound delivery protocol because of the large number of design variables. The OMC dose increased from 45.0% in the baseline model to 72.4% in the optimized system. The optimization framework developed in this study can be easily adapted for the delivery of drugs to other sites in the nose such as the ethmoid sinus and olfactory region.

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“…Balata et al [5] investigated propolis organogel as a novel topical delivery system for treating wounds. Topical delivery systems are employed not only to treat skin related problems, but also for complications associated with eyes, [6] nose, [7], vagina [8], or rectum [9] etc. where patients compliance and satisfaction are essential.…”

Section: Introductionmentioning

confidence: 99%

Groundnut oil based emulsion gels for passive and iontophoretic delivery of therapeutics

Singh

Yadav

Kulanthaivel

et al. 2016

Designed Monomers and Polymers

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There is a persistent demand for an efficient drug delivery system, suitable for the delivery of both hydrophilic and lipophilic drugs. This study explores groundnut oil-based emulsion gels for the above-mentioned application. On the basis of stability, two representative gels OG5-80 (low oil content) and OG7-45 (high oil content) were studied further. Analysis of microarchitecture by ESEM and confocal microscopy, in conjugation with fluorescence recovery after photobleaching, confirmed the conversion of the dispersion phase from oil-continuous (OG7-45) to bicontinuous (OG5-80) with increasing water proportion. The gels were viscoelastic with unique stress relaxation properties. Passive and active (iontophoretic) release kinetics of the drugs showed differential release patterns. Mathematical modeling elucidated composition-dependent temporal variation in the drug release and stress relaxation patterns. In vitro cell viability study, cell cycle analysis, and immunocytochemistry divulged compatibility of the gels to human skin cells (keratinocytes). Drugloaded gels were found active against B. subtilis and E. coli. Hence, groundnut oil-based emulsion gels can be an efficient and stable multimodal carrier system for the passive and the active delivery of both hydrophilic and lipophilic drugs.

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Comparison of nasal sprays and irrigations in the delivery of topical agents to the olfactory mucosa

Cited by 43 publications

References 21 publications

Effect of ionic compositions in nasal irrigations on human olfactory thresholds

Effect of ionic compositions in nasal irrigations on human olfactory thresholds

Numerical optimization of targeted delivery of charged nanoparticles to the ostiomeatal complex for treatment of rhinosinusitis

Groundnut oil based emulsion gels for passive and iontophoretic delivery of therapeutics

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