Comparison of neuroprotective effects of dihydrotestosterone, 17β-estradiol, and Pueraria mirifica herb extract on cognitive impairment in androgen deficient male rats

Fainanta, Taratorn; Jaroenporn, Sukanya; Wititsuwankul, Patteera; Malaivijitnond, Suchinda

doi:10.1016/j.yhbeh.2022.105198

Cited by 2 publications

(7 citation statements)

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“…As for the countries where the experiments were conducted, China had the most cases (n = 20) [ 8 , 9 , 13 , 15 , 16 , 19 , 23 , 26 , 27 , 28 , 29 , 30 , 32 , 36 , 38 , 39 , 46 , 47 , 48 , 49 ], followed by Japan (n = 8) [ 12 , 20 , 40 , 41 , 42 , 43 , 44 , 45 ], Korea (n = 6) [ 24 , 31 , 33 , 34 , 35 , 37 ] and Taiwan (n = 3) [ 21 , 22 , 23 ]. Thailand [ 18 ], the United States [ 17 ], Mexico [ 11 ] and Poland [ 25 ] were each associated with one study.…”

Section: Resultsmentioning

confidence: 99%

“…In herbal medicine extraction, 17 studies used water extraction [ 9 , 13 , 14 , 17 , 20 , 21 , 22 , 27 , 31 , 33 , 39 , 40 , 42 , 45 , 47 , 48 ]; 6 studies used ethanol [ 10 , 16 , 18 , 24 , 34 , 35 ]; and 2 studies used carbon dioxide fluid [ 23 , 26 ]. Three studies used a suspension of the herbal formula Guilingji [ 15 , 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study did not report the route of administration [ 11 ]. Eighteen studies tested the dose of herbal medicine at a single concentration [ 11 , 13 , 17 , 18 , 19 , 20 , 21 , 24 , 28 , 31 , 37 , 38 , 39 , 40 , 42 , 46 , 48 , 50 ], and in 21 studies, 2 or 3 types of concentrations were tested [ 8 , 9 , 10 , 14 , 15 , 16 , 22 , 23 , 25 , 26 , 27 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 41 , 45 , 47 ]. The other two studies did not report the dosage used [ 12 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…The animals used in the experiments were Sprague-Dawley rats (n = 15) [ 11 , 13 , 14 , 15 , 16 , 18 , 22 , 24 , 29 , 30 , 32 , 33 , 34 , 35 , 47 ], C57BL/6 mice (n = 8) [ 8 , 10 , 28 , 31 , 36 , 44 , 45 , 46 ], Kunming mice (n = 4) [ 19 , 23 , 26 , 27 ], ICR mice (n = 3) [ 9 , 39 , 48 ], senescence-accelerated mouse-prone 8 (SAMP8) mice (n = 3) [ 12 , 20 , 40 ], BALB/c mice (n = 2) [ 37 , 38 ], hairless mice (n = 2) [ 42 , 43 ], CB6F1 mice (n = 1) [ 17 ], Swiss mice (n = 1) [ 25 ], Wistar Kyoto rats (n = 1) [ 21 ], Wild-type and NPY knockout mice (n = 1) [ 44 ] and Klotho-hypomorphic (kl/kl/) mice (n = 1) [ 41 ]. Regarding sex, five studies used both male and female mice or rats [ 17 , 27 , …”

Section: Resultsmentioning

confidence: 99%

“…Nine research papers have been published on learning and memory, cognition and emotion [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Seven of these focused on single herbal medicines [ 12 , 13 , 14 , 16 , 17 , 18 , 19 ], and two focused on complex herbal medicines [ 15 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

et al. 2023

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Background: The world’s population is rapidly aging, and attention to and research on the increase in life expectancy and age-related diseases are needed. This study aimed to review the in vivo studies on the anti-aging effects of herbal medicines. Methods: In vivo studies of single or complex herbal medicines for anti-aging that were published in the last five years were included in this review. The following databases were used: PubMed, Scopus, ScienceDirect, Web of Science and EMBASE. Results: A total of 41 studies were considered eligible for the review. The articles were classified into body organs and functions, experimental country, herbal medicine, extraction method, administration route, dosage, duration, animal model, aging-induced method, sex, number of animals per group, and outcomes and mechanisms A single herbal extract was used in a total of 21 studies including Alpinia oxyphylla Miq., Acanthopanax senticosus and Lyceum barbarum, and a multi-compound herbal prescription was used in a total of 20 studies, including Modified Qiongyu paste, Wuzi Yanzong recipe, etc. Each herbal medicine had anti-aging effects on learning and memory, cognition, emotion, internal organs, gastrointestinal tracts, sexual functions, musculoskeletal function and so on. The common mechanisms of action were antioxidant and anti-inflammatory, and various effects and mechanisms for each organ and function were identified. Conclusions: Herbal medicine exhibited beneficial effects on anti-aging in various parts of the body and its function. Further investigation of the appropriate herbal medicine prescriptions and their components is recommended.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

et al. 2023

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Inhibition of LPS-Induced Microglial Activation by the Ethyl Acetate Extract of Pueraria mirifica

Jantaratnotai

Thampithak

Utaisincharoen

et al. 2022

IJERPH

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Microglial activation has been found to play a crucial role in various neurological disorders. Proinflammatory substances overproduced by activated microglia, such as cytokines, chemokines, reactive oxygen species, and nitric oxide (NO), can result in neuroinflammation that further exacerbates the course of the diseases. This study aimed to explore the anti-inflammatory effect of the ethyl acetate extract of Pueraria mirifica on microglial activation. Lipopolysaccharide (LPS)-induced inflammation was used as a model to investigate the effects of P. mirifica on HAPI (highly aggressive proliferating immortalized), a rat microglial cell line. Administration of ethyl acetate extract from the tuberous roots of P. mirifica to HAPI cells dose-dependently reduced NO production and iNOS expression induced by LPS. Attenuation of IRF-1 (interferon regulatory factor-1) induction, one of the transcription factors governing iNOS expression, suggested that the inhibitory effect on NO production by the plant extract was at least partially mediated through this transcription factor. In addition, LPS-stimulated mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL-6 (interleukin-6), and TNF-α (tumor necrosis factor-α) was also suppressed with P. mirifica extract pretreatment. This study indicates that the ethyl acetate extract of P. mirifica could potentially serve as an anti-inflammatory mediator and may be useful in relieving the severity of neurological diseases where microglia play a role.

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Comparison of neuroprotective effects of dihydrotestosterone, 17β-estradiol, and Pueraria mirifica herb extract on cognitive impairment in androgen deficient male rats

Cited by 2 publications

References 59 publications

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

Inhibition of LPS-Induced Microglial Activation by the Ethyl Acetate Extract of Pueraria mirifica

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