Comparison of neuropsychological and functional outcomes in Alzheimer's disease patients with good or bad response to a cognitive stimulation treatment: a retrospective analysis

Martínez-Moreno, Mar; Cerulla, Noemí; Chico, Gloria; Quintana, M.; Garolera, Maite

doi:10.1017/s104161021600123x

Cited by 7 publications

(24 citation statements)

References 30 publications

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“…A retrospective observational study was conducted between 2004 and 2012 in 60 patients with AD who followed a 1-year cognitive stimulation program. 9 A cognitive and functional assessment was performed before and after the intervention. The MMSE scores were used to distinguish good responders (higher cognitive performance) from nonresponders (poor cognitive performance) at baseline.…”

Section: Clinical Trials Of Cognitive Stimulation In Admentioning

confidence: 99%

What do we know from clinical trials on exercise and Alzheimer's disease?

Shen

2016

Journal of Sport and Health Science

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Alzheimer’s disease (AD) is the most common form of dementia in elderly with major symptoms of a general term for memory loss and other intellectual abilities impairment which are serious enough to interfere with daily life. While there is no treatment can prevent and revise the cognitive function impairment in AD, physical activity becomes a potential beneficial intervention for AD. Multiple evidences suggested that exercise in general plays beneficial roles in improving brain function. Most common mechanisms of exercise-induced enhancement of brain function are including alteration of neurogenesis, neuron plasticity, neuronal signaling and receptors, as well as neuronal networks. This mini review includes most recent clinical studies and focuses on the effects of physical exercise, cognitive stimulation, and combination of both physical and cognitive training on protection and rescue cognitive decline in people with AD.

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Section: Clinical Trials Of Cognitive Stimulation In Admentioning

confidence: 99%

What do we know from clinical trials on exercise and Alzheimer's disease?

Shen

2016

Journal of Sport and Health Science

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“…semantic), recall, verbal fluency, orientation, visual skills, numeracy, auditory comprehension and motor skills (see Table 3 in Supplementary Material ). Studies using these measures argued for the importance of measuring more specific areas of cognition and memory, as generic measures might not show any effect ( Capotosto et al, 2017 ; Cavallo & Angilletta, 2017 ; da Cruz et al., 2015 ; Farina et al, 2006 ; Hall et al, 2013 ; Martinez-Moreno et al., 2016 ; Piras et al, 2017 ; Spector et al, 2003 ).…”

Section: Resultsmentioning

confidence: 99%

“…Four studies reported on the length of time for each assessment, these were identified as 45–90 min in duration ( Bergamaschi et al., 2013 ; Hall et al, 2013 ; Martinez-Moreno et al., 2016 ; Woods et al, 2006 ). Four studies reported their assessment process used individual or face-to-face interviews, with the order of the tests remaining the same across all participants ( Bergamaschi et al, 2013 ; Hall et al, 2013 ; Martinez-Moreno et al., 2016 ; Middlestadt et al., 2016 ).…”

Section: Resultsmentioning

confidence: 99%

“…Three studies (Kelly et al, 2017;Liu et al, 2020;Stewart et al, 2017) Seventeen studies used the MMSE and another cognitive assessment (both global tests and individual tests). This varied, 11 used the ADAS-Cog, and seven used other cognitive assessments: Clinical Dementia Rating Scale (Hughes et al, 1982;Morris, 1993); Esame Neuropsicolgico Breve2 , 2004;Bottino et al, 2005) Sessions and discussion groups to enhance cognitive and social function (Martinez et al, 2016(Martinez et al, , p.1824(Martinez et al, , p.1824) NEUROvitals sinnreich (modified version) () Sessions start with a report on participants' mood followed by exercises to support: Executive function, memory, language and cognition. Time is also provided for muscle relaxation and mindfulness and sensory stimulation (Middlestadt et al, 2016, p.256, p.256) (Mondini et al, 2011); Milan Overall Dementia Assessment (Brazzelli et al, 1994); Mattis Dementia Rating Scale (Mattis, 1988); Short Intelligence Test; Repeatable Battery for the Assessment of Neuropsychological Status Stimulus Booklet A (Randolph et al, 1998).…”

Section: Measures Used To Assess Cognitionmentioning

confidence: 99%

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Exploring outcome measures with cognitive stimulation therapies and how these relate to the experiences of people with dementia: A narrative literature review

2022

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A narrative literature review was undertaken to consider the outcome measures used in research on cognitive stimulation therapy (CST), cognitive training (CT) and cognitive stimulation (CS) interventions. This review extends findings from previous reviews by including a broad range of study methodologies, both qualitative and quantitative, and explored whether participant experiences of taking part in the research are discussed. A database search identified 1261 articles matching the search criteria, with 29 included in this review. Studies tended to use the manualised CST model, with 11 other models identified. Randomised control trials were chosen as the most used method to explore impact. Across the studies, 65 different outcome measures were used with people with dementia, and only four studies used a qualitative approach. Little information is provided on the assessment process in terms of time taken, assessor, or of the experience of the person with dementia. There is heterogeneity of measures used, within and across domains, and number, and agreement or consistency of measures would provide greater comparability across CS studies. Gaps in reporting were noted on the detail of the assessment process and the experience of people with dementia taking part in this research.

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“…All sessions are conducted by an occupational therapist and supervised by a clinical neuropsychologist who design the CS for each patient. All sessions include reality orientation therapy for 10 min, and training in attention and concentration, memory, language, calculation, gnosias, praxias, or executive function for 50 min [for more details see, 47 ].…”

Section: Main Textmentioning

confidence: 99%

Transcranial magnetic stimulation intervention in Alzheimer’s disease: a research proposal for a randomized controlled trial

et al. 2018

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ObjectiveAlzheimer’s disease is a major health problem in our society. To date, pharmacological treatments have obtained poor results and there is a growing interest in finding non-pharmacological interventions for this disease. Transcranial magnetic stimulation (TMS) is a non-invasive technique that is able to induce changes in brain activity and long-term modifications in impaired neural networks, becoming a promising clinical intervention. Our goal is to study the benefit of individualized TMS targeting based on the patient’s functional connectivity (personalized targeting), and short duration TMS protocol, instead of current non-individualized and longer session approaches. A double blind randomized controlled trial will be conducted to assess the effects of TMS treatment immediately, 1 month, 3 months and 6 months after the end of the intervention. Fifty-four patients with a diagnosis of Alzheimer’s disease will be randomly allocated into experimental (active TMS), sham control, or conventional intervention control group. We will quantify changes in cognitive, functional, and emotional deficits in Alzheimer patients, as well as the functional connectivity changes induced by the TMS treatment.ResultsWe expect to demonstrate that personalized TMS intervention has a measurable positive impact in cognition, emotion, daily living activities and brain connectivity, thus representing a potential treatment for Alzheimer’s disease.Trial registration The trial has been prospectively registered at ClinicalTrials.gov, identifier NCT03121066. Date of registration: 04/19/2017

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Comparison of neuropsychological and functional outcomes in Alzheimer's disease patients with good or bad response to a cognitive stimulation treatment: a retrospective analysis

Cited by 7 publications

References 30 publications

What do we know from clinical trials on exercise and Alzheimer's disease?

What do we know from clinical trials on exercise and Alzheimer's disease?

Exploring outcome measures with cognitive stimulation therapies and how these relate to the experiences of people with dementia: A narrative literature review

Transcranial magnetic stimulation intervention in Alzheimer’s disease: a research proposal for a randomized controlled trial

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