2006
DOI: 10.1248/bpb.29.1068
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Comparison of Nicotine Pharmacokinetics in Healthy Japanese Male Smokers Following Application of the Transdermal Nicotine Patch and Cigarette Smoking

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Cited by 14 publications
(5 citation statements)
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“…In fact, although this was a safety/dose escalation study, more subjects with high antibody responses quit smoking during the trial than did those with lower antibody responses, even though subjects were not asked to quit smoking. The NicQb vaccine also elicited significant quantities of anti-NIC antibodies [30], and a similar observation was made that subjects in the upper third of antibody responses had almost double the quit rate of placebo subjects (57% vs 31%). Subjects in the TA-NIC vaccine trial were immunized with four doses over the first 8 weeks and then given a booster dose at 32 weeks.…”
Section: Antibody and Drug Pharmacodynamics And Pharmacokineticssupporting
confidence: 56%
“…In fact, although this was a safety/dose escalation study, more subjects with high antibody responses quit smoking during the trial than did those with lower antibody responses, even though subjects were not asked to quit smoking. The NicQb vaccine also elicited significant quantities of anti-NIC antibodies [30], and a similar observation was made that subjects in the upper third of antibody responses had almost double the quit rate of placebo subjects (57% vs 31%). Subjects in the TA-NIC vaccine trial were immunized with four doses over the first 8 weeks and then given a booster dose at 32 weeks.…”
Section: Antibody and Drug Pharmacodynamics And Pharmacokineticssupporting
confidence: 56%
“…Therefore, it is a reliable indicator of recent nicotine intake [7]. However, for patients undergoing nicotine replacement therapy (NRT) using nicotine gum and nicotine patches, cotinine cannot be used as an indicator of smoking cessation because nicotine and cotinine are present at the same levels as smokers [8][9][10][11][12]. On the other hand, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine has been reported as an exposure indicator that is not affected by NRT [13,14].…”
Section: Introductionmentioning
confidence: 99%
“…While the determinants of tobacco use are complex and include environmental and social factors (Tobacco Advisory Group of the Royal College of Physicians, 2007), the rapid absorption of a sufficient dose of nicotine has been proposed to be an important factor for consumer acceptability of tobacco and nicotine products (Foulds et al, 2003). Nicotine replacement therapy (NRT) products, on average, provide the user much slower absorption and lower maximum plasma concentration (C max ) of nicotine compared with cigarettes (Benowitz, Porchet, Sheiner, & Jacob, 1988; Russell, Jarvis, Feyerabend, & Ferno, 1983; Sobue, Sekiguchi, Kikkawa, Akasaki, & Irie, 2006). Some authorities suggest this differing pharmacokinetic profile is a contributing factor to NRT products’ limited success as aids for quitting smoking (Britton, 2008).…”
Section: Introductionmentioning
confidence: 99%